{"id":12280,"date":"2026-10-22T10:00:00","date_gmt":"2026-10-22T10:00:00","guid":{"rendered":"https:\/\/bioprofile.com\/?page_id=12280"},"modified":"2026-11-05T17:07:54","modified_gmt":"2026-11-05T17:07:54","slug":"homa-ir","status":"publish","type":"page","link":"https:\/\/bioprofile.com\/de\/biomarkers\/homa-ir\/","title":{"rendered":"HOMA-IR"},"content":{"rendered":"\n<div id=\"content\" tabindex=\"-1\"><\/div>\n<style>@import url('https:\/\/fonts.googleapis.com\/css2?family=Poppins:ital,wght@0,400;0,600;0,700;0,800;1,400&display=swap');\n\/* ===========================================================================\n   BioProfile advertorial, the design Jesse approved on 2026-07-30, expressed\n   as a WordPress design system.\n\n   THE @import IS LOAD BEARING and must stay the first thing in this sheet (a\n   CSS @import after any rule is dropped by the parser). elementor_canvas does\n   not enqueue the theme's fonts, so without it the whole page falls back to the\n   system font. Caught by LOOKING at the live page on 2026-07-30, right after\n   the template was switched to canvas.\n\n   Everything is scoped to `.bp-adv`, so nothing here can reach the rest of\n   bioprofile.com, and core blocks are styled BY ELEMENT so a heading, a\n   paragraph, a quote, a list, an image or a button inserted by hand inside the\n   advertorial comes out on-design with no class to remember.\n\n   Jesse's design feedback, 2026-07-29 23:38, point by point:\n   1. the light green and the dark green are the preferred colours; grey may be\n      used but the page must NOT open grey;\n   2. more colour and variation across sections, e.g. a colour block on the left\n      or the right side of a section, without overdesign;\n   3. ONE H1, plain text on white; everything else H2 or H3; an H2 may carry its\n      own background colour so the page can be read from the headings alone; an\n      H3 keeps its section background and gets a bigger font size;\n   4. reuse the results page design feel;\n   5. Written by \/ Verified by, the placeholder blocks and noindex stay.\n\n   COLOUR PROVENANCE. Not one hex is invented.\n   - #b7cb32  LIGHT GREEN, brand manual \"colours rejuvenation protocol\"\n              (R183 G203 B51). Same value as --bp-lime in\n              brands\/bioprofile\/brand\/tokens.md.\n   - #006b62  DARK GREEN, brand manual, nourish the cells (R0 G107 B98).\n   - #005859  brand manual primary teal, the value the brand is built on.\n   - #228a62  brand manual, challenge the body (R34 G138 B98).\n   - #7ca64c  brand manual, calm the mind (R124 G166 B76).\n   - #dbd4cd  brand manual \"additional color\", the warm neutral.\n   - #B7CB3329 is the brand token --bp-lime-soft (light green at 16 percent).\n   - the gradients are the brand token layer's own, copied verbatim.\n\n   SPECIFICITY NOTE. Elementor's global kit emits `.elementor-kit-6 h2` style\n   rules at (0,1,1). Element rules below are written `.bp-adv h2`, also (0,1,1),\n   and win on source order because this sheet is inline in the body while the\n   kit is a <link> in the head. Component rules that MUST NOT lose carry two\n   classes, e.g. `.bp-adv .wp-block-button__link`.\n\n   LAYOUT NOTE. Vertical rhythm uses `margin-block` and never the `margin`\n   shorthand, so the measure rule `.bp-adv-sec > * { margin-inline: auto }` can\n   centre a block without being outranked by its own element rule.\n   =========================================================================== *\/\n\n.bp-adv {\n  --bp-ink: #212527;\n  --bp-teal: #005859;\n  --bp-forest: #006B62;\n  --bp-emerald: #228A62;\n  --bp-olive: #7CA64C;\n  --bp-lime: #B7CB33;\n  --bp-lime-soft: #B7CB3329;\n  --bp-sand: #DBD4CB;\n  --bp-white: #FFFFFF;\n  --bp-foot: #6b6b6b;\n  --bp-grad-dark: linear-gradient(237deg, rgba(0,88,89,0.00) 62.94%, #005859 100%), linear-gradient(90deg, rgba(34,138,98,0.00) 40%, #228A62 100%), #006B62;\n  --bp-grad-lime: linear-gradient(110deg, rgba(183,203,51,0.00) 36.06%, rgba(183,203,51,0.25) 97.65%), #FFFFFF;\n  --bp-font: 'Poppins','Segoe UI',Arial,sans-serif;\n  --bp-fs-h1: 44px; --bp-fs-h2: 31px; --bp-fs-h3: 24px; --bp-fs-pre: 15px;\n  --bp-fs-body: 17px; --bp-fs-small: 14px; --bp-fs-foot: 13px; --bp-fs-btn: 17px;\n  --bp-lh-body: 1.75;\n  --bp-s-1: 4px; --bp-s-2: 8px; --bp-s-3: 12px; --bp-s-4: 16px;\n  --bp-s-5: 24px; --bp-s-6: 32px; --bp-s-7: 44px; --bp-s-8: 72px;\n  --bp-measure: 760px; --bp-side: 40px;\n  --bp-radius-photo: 16px; --bp-radius-btn: 10px; --bp-radius-card: 20px;\n  --bp-shadow: 0 10px 30px rgba(0,88,89,0.10);\n  font-family: var(--bp-font);\n  font-size: var(--bp-fs-body);\n  line-height: var(--bp-lh-body);\n  color: var(--bp-ink);\n  background: var(--bp-white);\n  -webkit-font-smoothing: antialiased;\n}\n.bp-adv, .bp-adv * { box-sizing: border-box; }\n.bp-adv p, .bp-adv li, .bp-adv h1, .bp-adv h2, .bp-adv h3, .bp-adv blockquote,\n.bp-adv a, .bp-adv cite, .bp-adv span { overflow-wrap: break-word; min-width: 0; }\n\n\/* THE TOGGLE. One word in the block's own \"Additional CSS class(es)\" field\n   hides an optional component on the front end without deleting anything. *\/\n.bp-adv .bp-off { display: none !important; }\n\n\/* the page opens on green, never on grey (his point 1) *\/\n.bp-adv .bp-adv-rule {\n  height: 6px; border: 0; margin-block: 0; max-width: none;\n  background: linear-gradient(90deg, #005859 0%, #006B62 38%, #228A62 66%, #B7CB33 100%);\n}\n\n\/* --- section surfaces ------------------------------------------------------ *\/\n.bp-adv-sec { position: relative; background: var(--bp-white);\n  padding: var(--bp-s-8) var(--bp-side); margin-block: 0; }\n\/* the measure: every direct child of a section is the 760px text column *\/\n.bp-adv-sec > * { max-width: var(--bp-measure); margin-inline: auto; }\n.bp-adv-sec > *:last-child { margin-block-end: 0; }\n.bp-adv-sec--wash  { background: linear-gradient(180deg, #B7CB331F 0%, #B7CB3312 100%), #FFFFFF; }\n.bp-adv-sec--dark  { background: var(--bp-grad-dark); color: var(--bp-white); }\n.bp-adv-sec--dark p, .bp-adv-sec--dark cite, .bp-adv-sec--dark li { color: var(--bp-white); }\n.bp-adv-sec--offer { background: var(--bp-grad-lime); text-align: center; }\n.bp-adv-sec--hero  { padding-block-start: var(--bp-s-6); }\n.bp-adv-sec--disclosure { padding-block: var(--bp-s-6);\n  border-top: 1px solid var(--bp-sand); }\n\n\/* --- the side accent bar, his own example (\"a colour block on the left or the\n       right side of a section\"), design rev 3: a slim vertical bar hugging the\n       text column rather than a wide margin panel. Below 1100px the margin is\n       gone, so it becomes a slim top edge. ---------------------------------- *\/\n.bp-adv-rail { overflow: hidden; }\n.bp-adv-rail::before {\n  content: \"\"; position: absolute; top: var(--bp-s-7); bottom: var(--bp-s-7);\n  width: 6px; border-radius: 3px;\n  background: linear-gradient(180deg, var(--bp-forest) 0%, var(--bp-lime) 100%);\n}\n.bp-adv-rail--left::before  { left: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n.bp-adv-rail--right::before { right: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n@media (max-width: 1099px) {\n  .bp-adv-rail::before { left: 0; right: 0; width: auto; bottom: auto; top: 0;\n    height: 4px; border-radius: 0; background: var(--bp-lime); }\n}\n\n\/* --- CORE BLOCKS, styled by element. This is the part that makes an inserted\n       block come out on-design with no class. --------------------------------- *\/\n.bp-adv p { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv h1 { font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); }\n\/* an H2 is its own colour band, so the page can be read from the headings\n   alone (his point 3). Dark green on light sections, light green on the dark\n   one, so a heading always wins against its own background. *\/\n.bp-adv h2 {\n  font-size: var(--bp-fs-h2); font-weight: 700; line-height: 1.28;\n  margin-block: 0 var(--bp-s-5);\n  background: var(--bp-grad-dark); color: var(--bp-white);\n  padding: var(--bp-s-4) var(--bp-s-5);\n  border-radius: var(--bp-radius-btn);\n  border-left: 6px solid var(--bp-lime);\n}\n.bp-adv-sec--dark h2 { background: var(--bp-lime); color: var(--bp-ink);\n  border-left-color: var(--bp-forest); }\n\/* H3: same background as its section, bigger font (his point 3, verbatim) *\/\n.bp-adv h3 { font-size: var(--bp-fs-h3); font-weight: 700; line-height: 1.35;\n  color: var(--bp-forest); background: transparent; margin-block: 0 var(--bp-s-3); }\n.bp-adv-sec--dark h3 { color: var(--bp-lime); }\n.bp-adv ul, .bp-adv ol { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); padding-left: var(--bp-s-5); }\n.bp-adv li { margin-block-end: var(--bp-s-2); }\n.bp-adv a { color: var(--bp-teal); text-decoration: underline; }\n.bp-adv a:hover { color: var(--bp-olive); }\n.bp-adv-sec--dark a, .bp-adv-sec--dark strong { color: var(--bp-lime); }\n.bp-adv strong { font-weight: 700; }\n\/* the highlight pill. Colours ride on the inline style core writes, so only\n   the shape lives here and any <mark> in the article picks it up. *\/\n.bp-adv mark {\n  padding: 0 10px; border-radius: 10px; display: inline;\n  -webkit-box-decoration-break: clone; box-decoration-break: clone;\n}\n\/* figures match the approved page exactly: card radius plus the soft shadow,\n   and a left-aligned caption rather than core's centred one *\/\n.bp-adv .wp-block-image { margin-block: var(--bp-s-5); margin-inline: auto; }\n.bp-adv .wp-block-image img { display: block; width: 100%; height: auto;\n  border-radius: var(--bp-radius-card); box-shadow: var(--bp-shadow); }\n.bp-adv .wp-block-image figcaption { font-size: var(--bp-fs-foot); line-height: 1.55;\n  color: var(--bp-foot); text-align: left; margin-block: var(--bp-s-2) 0; }\n.bp-adv .wp-block-embed, .bp-adv .wp-block-video { margin-block: var(--bp-s-5); }\n.bp-adv .wp-block-embed iframe, .bp-adv .wp-block-video video {\n  width: 100%; border-radius: var(--bp-radius-photo); }\n.bp-adv .wp-block-separator:not(.bp-adv-rule) { border: 0; border-top: 1px solid var(--bp-sand);\n  margin-block: var(--bp-s-5); }\n\n\/* quotes: core pullquote and core quote both land on the lime rule. The\n   font-size reset undoes core's own 1.5em on the figure, which would otherwise\n   leak into anything inside the quote that has no size of its own. *\/\n\/* margin-inline is load bearing, and it must be `auto` rather than `0`.\n   `blockquote` and `figure` carry a 40px side margin in the browser's own\n   default stylesheet, which indents the quote inside its rule and makes the\n   copy wrap early on a phone. But these blocks are direct children of a\n   section, so zeroing the side margin also defeats the measure rule\n   `.bp-adv-sec > * { margin-inline: auto }` and pins them to the left edge. *\/\n.bp-adv .wp-block-pullquote, .bp-adv .wp-block-quote {\n  border: 0; border-left: 5px solid var(--bp-lime); background: transparent;\n  padding: var(--bp-s-2) 0 var(--bp-s-2) var(--bp-s-5);\n  margin-block: var(--bp-s-5); margin-inline: auto;\n  text-align: left; font-size: var(--bp-fs-body);\n}\n.bp-adv .wp-block-pullquote blockquote { border: 0; margin: 0; padding: 0; }\n.bp-adv .wp-block-pullquote p, .bp-adv .wp-block-quote p {\n  font-size: 24px; line-height: 1.45; font-weight: 600;\n  margin-block: 0 var(--bp-s-2); color: var(--bp-forest); }\n.bp-adv .wp-block-pullquote cite, .bp-adv .wp-block-quote cite {\n  display: block; margin: 0; font-size: var(--bp-fs-small); color: var(--bp-foot);\n  font-style: normal; text-transform: none; }\n\n\/* buttons: two classes so core's own .wp-block-button__link cannot win *\/\n.bp-adv .wp-block-buttons { display: flex; justify-content: center;\n  margin-block: 0 var(--bp-s-4); }\n.bp-adv .wp-block-button__link {\n  display: inline-flex; align-items: center; justify-content: center; min-height: 48px;\n  background: var(--bp-teal); color: var(--bp-white); font-size: var(--bp-fs-btn);\n  font-weight: 700; line-height: 1.2; border-radius: var(--bp-radius-btn);\n  padding: 15px 44px; text-decoration: none; transition: background 250ms ease;\n  box-shadow: var(--bp-shadow);\n}\n.bp-adv .wp-block-button__link:hover { background: var(--bp-olive); color: var(--bp-white); }\n\n\/* --- slot 1: pre-headline, headline, sub-headline (Jesse's headline skill) --- *\/\n.bp-adv .bp-adv-preheadline {\n  color: var(--bp-forest); font-size: var(--bp-fs-pre); font-weight: 600; line-height: 1.5;\n  border-left: 4px solid var(--bp-lime); padding-left: var(--bp-s-3);\n  margin-block: 0 var(--bp-s-4);\n}\n.bp-adv .bp-adv-subheadline { font-size: 21px; line-height: 1.5; font-weight: 600;\n  color: var(--bp-forest); margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-standfirst { font-size: 19px; line-height: 1.65;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-lede { font-size: 18px; line-height: 1.7;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-byline { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  line-height: 1.6; margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-socialproof { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  margin-block: 0 var(--bp-s-5); }\n\/* the offer headline above the CTA. Jesse asked for a second H1 here; the brand\n   doc's accessibility rule is one h1 per page, so it is rendered at H1 size and\n   stays an h2 element. Named in the close as the one design conflict. *\/\n.bp-adv h2.bp-adv-offerhead {\n  font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); text-align: center; color: var(--bp-ink);\n  background: none; padding: 0; border: 0; border-radius: 0;\n}\n\n\/* --- Written by + Verified by. The avatar is the first child and spans the\n       three text rows, so the whole box is four ordinary paragraphs and stays\n       editable without nested columns. ---------------------------------------- *\/\n.bp-adv .bp-adv-authors {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-top: 4px solid var(--bp-lime); border-radius: var(--bp-radius-card);\n  box-shadow: var(--bp-shadow); padding: var(--bp-s-5);\n  margin-block: 0 var(--bp-s-4);\n  \/* auto-fit, so switching the verified box off leaves one full-width author\n     rather than a half-empty card *\/\n  display: grid; grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));\n  gap: var(--bp-s-5); align-items: start;\n}\n.bp-adv .bp-adv-author {\n  display: grid; grid-template-columns: 62px 1fr; gap: 0 var(--bp-s-3);\n  align-items: start; min-width: 0;\n}\n.bp-adv .bp-adv-avatar {\n  grid-row: 1 \/ span 3; width: 62px; height: 62px; border-radius: 50%;\n  background: #B7CB331F; border: 2px dashed var(--bp-olive);\n  display: flex; align-items: center; justify-content: center;\n  font-size: 10px; font-weight: 700; letter-spacing: 0.06em; color: var(--bp-forest);\n  margin-block: 0;\n}\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-avatar {\n  border-color: var(--bp-sand); background: #fff; color: var(--bp-foot); }\n.bp-adv .bp-adv-author-role {\n  font-size: 11px; font-weight: 700; letter-spacing: 0.08em; text-transform: uppercase;\n  color: var(--bp-forest); line-height: 1.6; margin-block: 0; }\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-author-role { color: var(--bp-foot); }\n.bp-adv .bp-adv-author-name { font-size: 17px; font-weight: 700; line-height: 1.35;\n  margin-block: 0; }\n.bp-adv .bp-adv-author-cred { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.55; margin-block: 0; }\n\/* the optional wrapper must not break the two-column grid of the box *\/\n.bp-adv .bp-adv-authors > .bp-optional { display: contents; }\n.bp-adv .bp-adv-authors > .bp-optional.bp-off { display: none !important; }\n\n\/* --- placeholders: image slot, video slot ---------------------------------- *\/\n.bp-adv .bp-slot {\n  display: flex; align-items: center; justify-content: center; text-align: center;\n  min-height: 180px; padding: var(--bp-s-4); margin-block: var(--bp-s-5) 0;\n  border: 2px dashed var(--bp-olive); border-radius: var(--bp-radius-photo);\n  background: #B7CB331F; color: var(--bp-forest);\n}\n.bp-adv .bp-slot p { font-size: var(--bp-fs-small); font-weight: 700; margin-block: 0; }\n.bp-adv .bp-slot--video { min-height: 260px; }\n\n\/* --- mid-article CTA band --------------------------------------------------- *\/\n.bp-adv .bp-adv-midcta {\n  background: var(--bp-grad-lime); border: 1px solid var(--bp-lime);\n  border-radius: var(--bp-radius-card); padding: var(--bp-s-5) var(--bp-s-4);\n  margin-block: var(--bp-s-6); text-align: center;\n}\n.bp-adv .bp-adv-midcta .wp-block-buttons { margin-block-end: var(--bp-s-2); }\n.bp-adv .bp-adv-midcta .bp-adv-foot { margin-block: 0; }\n\n\/* the closing CTA is one named unit in List View, so it moves and toggles as a\n   whole. It carries no box of its own: the spacing must read exactly as it does\n   on the approved page, where the three parts are plain siblings. *\/\n.bp-adv .bp-adv-ctablock { margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-ctablock .wp-block-buttons { margin-block-end: var(--bp-s-4); }\n.bp-adv .bp-adv-ctablock .bp-adv-foot { margin-block: 0; }\n\n\/* --- the condition, slot 8: the results page reference-card shape ----------- *\/\n.bp-adv .bp-adv-condition {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-left: 5px solid var(--bp-lime); border-radius: var(--bp-radius-btn);\n  padding: var(--bp-s-4) var(--bp-s-5); font-weight: 600; box-shadow: var(--bp-shadow);\n}\n\n\/* --- the numbers card: the results page focus panel, same gradient, same\n       radius, same lime figures (\"use more of that design\") ------------------ *\/\n.bp-adv .bp-adv-numcard {\n  background: linear-gradient(135deg, var(--bp-teal) 0%, var(--bp-forest) 100%);\n  border-radius: var(--bp-radius-card);\n  padding: var(--bp-s-6) var(--bp-s-5) var(--bp-s-5);\n  box-shadow: var(--bp-shadow); margin-block: var(--bp-s-5) 0;\n  position: relative; overflow: hidden;\n}\n.bp-adv .bp-adv-numcard::after {\n  content: \"\"; position: absolute; right: -70px; top: -70px; width: 240px; height: 240px;\n  border-radius: 50%; background: rgba(255,255,255,0.05); pointer-events: none;\n}\n.bp-adv .bp-adv-numcard .wp-block-columns {\n  position: relative; z-index: 1; gap: var(--bp-s-5); margin-block: 0; }\n.bp-adv .bp-adv-numcard .wp-block-column { min-width: 0; }\n.bp-adv .bp-adv-num-v { font-size: 44px; font-weight: 700; line-height: 1.12;\n  color: var(--bp-lime); text-align: center; margin-block: 0 var(--bp-s-2); }\n.bp-adv .bp-adv-num-l { font-size: var(--bp-fs-small); line-height: 1.5;\n  color: rgba(255,255,255,0.92); text-align: center; margin-block: 0; }\n.bp-adv .bp-adv-numsrc { margin-block: var(--bp-s-5) 0; }\n\n\/* --- the proof slot: a dashed card until a consented quote exists. 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Lees het hier.\",\"inLanguage\":\"nl-NL\",\"dateModified\":\"2026-10-10\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/homa-ir\/\"},\"isPartOf\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/homa-ir\/\"},\"publisher\":{\"@id\":\"https:\/\/bioprofile.com\/#organization\"},\"about\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/homa-ir\/#biomarker\"},\"citation\":[{\"@type\":\"CreativeWork\",\"name\":\"Gayoso-Diz P, Otero-Gonz\u00e1lez A, Rodriguez-Alvarez MX, et al. Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study. BMC Endocr Disord. 2013;13:47.\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24131857\/\"},{\"@type\":\"CreativeWork\",\"name\":\"Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9.\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3899825\/\"},{\"@type\":\"CreativeWork\",\"name\":\"BioProfile, de pakketten van het bloedonderzoek en de waarden in elk pakket.\",\"url\":\"https:\/\/bioprofile.com\/bloedonderzoek\/\"}]},{\"@type\":\"MedicalTest\",\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/homa-ir\/#biomarker\",\"name\":\"HOMA-IR\",\"alternateName\":[\"HOMA-IR\"]}]}<\/script>\n\n\n\n<section class=\"wp-block-group bp-adv bp-biomarker bp-biomarker--page is-layout-flow wp-block-group-is-layout-flow\">\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity bp-adv-rule\"\/>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--hero is-layout-flow wp-block-group-is-layout-flow\">\n\n<p class=\"bp-bm-crumbs wp-block-paragraph\"><a href=\"https:\/\/bioprofile.com\/de\/\">Startseite<\/a> \u203a <a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/\">Biomarker<\/a> \u203a <span>HOMA-IR<\/span><\/p>\n\n\n\n<h1 class=\"wp-block-heading bp-adv-h1\">HOMA-IR: Was Ihr Wert \u00fcber Insulinresistenz aussagt<\/h1>\n\n\n\n<p class=\"bp-adv-standfirst wp-block-paragraph\">In einer Zufallsstichprobe von 2459 spanischen Erwachsenen lag der Grenzwert f\u00fcr HOMA-IR bei 2,05. Das galt, als die Forschenden Merkmale betrachteten, die zusammen das Risiko f\u00fcr Stoffwechsel, Herz und Blutgef\u00e4\u00dfe erh\u00f6hen.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"bp-adv-lede wp-block-paragraph\">Auf dieser Seite lesen Sie, was HOMA-IR ist, was die Leitlinien \u00fcber einen zu niedrigen oder zu hohen Wert sagen, was Ihren Wert beeinflusst und welche Werte Sie am besten daneben betrachten.<\/p>\n\n\n\n<p class=\"bp-bm-names wp-block-paragraph\">Auch: HOMA-Index, homeostasis model assessment of insulin resistance. Im Labor: entf\u00e4llt.<\/p>\n\n\n\n<p class=\"bp-adv-byline wp-block-paragraph\">Aktualisiert am 10. Oktober 2026<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-group bp-bm-toc is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-inhoud\">Auf dieser Seite<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li><a href=\"#bp-in-het-kort\">Kurz gefasst<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-is-homa-ir\">Was ist HOMA-IR?<\/a><\/li>\n\n\n<li><a href=\"#bp-waarom-het-ertoe-doet\">Warum HOMA-IR wichtig ist<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-je-waarde-zegt\">Was Ihr HOMA-IR-Wert aussagt<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-het-beinvloedt\">Was Ihren HOMA-IR beeinflusst<\/a><\/li>\n\n\n<li><a href=\"#bp-welke-pakketten\">Welche BioProfile-Pakete HOMA-IR messen<\/a><\/li>\n\n\n<li><a href=\"#bp-waarden-die-erbij-horen\">Werte, die dazugeh\u00f6ren<\/a><\/li>\n\n\n<li><a href=\"#bp-hoe-gemaakt\">Wie diese Seite entstanden ist<\/a><\/li>\n\n\n<li><a href=\"#bp-bronnen\">Quellen<\/a><\/li>\n\n<\/ul>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-in-het-kort\">Kurz gefasst<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li>HOMA-IR ist eine Sch\u00e4tzung der Insulinresistenz, berechnet aus Ihrer N\u00fcchternglukose und Ihrem Insulin.<sup>[2]<\/sup><\/li>\n\n\n<li>Die Sch\u00e4tzung ist nicht sehr pr\u00e4zise: Der Variationskoeffizient f\u00fcr Insulinresistenz betr\u00e4gt 31%.<sup>[2]<\/sup><\/li>\n\n\n<li>Ein h\u00f6herer HOMA-IR kann auf ein h\u00f6heres Risiko f\u00fcr Stoffwechsel, Herz und Blutgef\u00e4\u00dfe hinweisen.<sup>[1]<\/sup><\/li>\n\n\n<li>Es gibt keinen festen Grenzwert: In einer spanischen Studie lag er zwischen 1,85 und 3,46, je nach Methode und Gruppe.<sup>[1]<\/sup><\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-is-homa-ir\">Was ist HOMA-IR?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ihre N\u00fcchternglukose und Ihr Insulin halten sich \u00fcber eine R\u00fcckkopplung im Gleichgewicht. HOMA vergleicht Ihre N\u00fcchternwerte mit einem Computermodell dieser R\u00fcckkopplung.<sup>[2]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">So sch\u00e4tzt das Modell, wie viel Insulinresistenz und wie viel verminderte Funktion der Betazellen bei einem erh\u00f6hten N\u00fcchternblutzucker eine Rolle spielen. HOMA-IR ist der Teil, der die Insulinresistenz betrifft.<sup>[2]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Die Sch\u00e4tzung stimmte gut mit einer aufwendigeren Messmethode \u00fcberein, dem euglyk\u00e4mischen Clamp (Rs = 0,88).<sup>[2]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarom-het-ertoe-doet\">Warum HOMA-IR wichtig ist<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Insulinresistenz h\u00e4ngt mit Ver\u00e4nderungen im Stoffwechsel und im Blutkreislauf zusammen. Sie h\u00e4ngt auch mit einem h\u00f6heren Risiko f\u00fcr Herz und Stoffwechsel zusammen.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Die Forschenden halten es f\u00fcr sinnvoller, einen Grenzwert auf Grundlage dieses Risikos zu w\u00e4hlen als auf Grundlage eines Perzentils der Bev\u00f6lkerung. So hilft HOMA-IR besser dabei, Menschen zu erkennen, bei denen mehrere Risikofaktoren zusammen das Risiko f\u00fcr Stoffwechsel, Herz und Blutgef\u00e4\u00dfe erh\u00f6hen.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gleichzeitig ist die Sch\u00e4tzung nicht pr\u00e4zise. Laut den Forschenden schr\u00e4nkt das ihre Verwendung ein.<sup>[2]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-je-waarde-zegt\">Was Ihr HOMA-IR-Wert aussagt<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Grenzwerte aus der EPIRCE-Studie<\/h3>\n\n\n\n<figure class=\"wp-block-table bp-bm-table\"><table><thead><tr><th>Grenzwert (HOMA-IR)<\/th><th>Worauf es hinweisen kann<\/th><th>F\u00fcr wen<\/th><\/tr><\/thead><tbody><tr><td>3,46<sup>[1]<\/sup><\/td><td>Grenzwert nach dem 90. Perzentil der Bev\u00f6lkerung<\/td><td>Erwachsene in einer spanischen Stichprobe<\/td><\/tr><tr><td>2,05<sup>[1]<\/sup><\/td><td>Grenzwert, der Merkmale ber\u00fccksichtigt, die zusammen das Risiko f\u00fcr Herz und Stoffwechsel erh\u00f6hen<\/td><td>Erwachsene in einer spanischen Stichprobe<\/td><\/tr><tr><td>1,85<sup>[1]<\/sup><\/td><td>Grenzwert f\u00fcr ein h\u00f6heres Risiko f\u00fcr Herz und Stoffwechsel<\/td><td>M\u00e4nner ohne bekannte St\u00f6rung der Blutzuckerregulation<\/td><\/tr><tr><td>H\u00e4ngt vom Alter ab<sup>[1]<\/sup><\/td><td>Der Grenzwert sollte sich mit dem Alter ver\u00e4ndern<\/td><td>Frauen ohne bekannte St\u00f6rung der Blutzuckerregulation<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"bp-bm-caption wp-block-paragraph\">Quelle: Gayoso-Diz und andere, EPIRCE-Studie (2013), eine Zufallsstichprobe von 2459 spanischen Erwachsenen. Diese Grenzwerte gelten f\u00fcr diese Gruppe.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HOMA-IR zu hoch<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ein HOMA-IR \u00fcber dem Grenzwert kann auf eine Insulinresistenz und auf ein h\u00f6heres Risiko f\u00fcr Stoffwechsel, Herz und Blutgef\u00e4\u00dfe hinweisen. Welcher Grenzwert passt, h\u00e4ngt von der Gruppe ab. Bei Frauen ohne bekannte St\u00f6rung der Blutzuckerregulation sollte sich der Grenzwert mit dem Alter ver\u00e4ndern.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BioProfile arbeitet an eigenen Zonen pro Wert, von Risiko bis optimal. Ein Arzt pr\u00fcft diese Zonen, bevor sie in Ihrem Ergebnis erscheinen.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-het-beinvloedt\">Was Ihren HOMA-IR beeinflusst<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Ihre N\u00fcchternglukose und Ihr Insulin<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">HOMA-IR wird aus Ihrer N\u00fcchternglukose und Ihrem Insulin berechnet. Ver\u00e4ndert sich einer der beiden Werte, ver\u00e4ndert sich auch das Ergebnis. Die Sch\u00e4tzung hing stark mit dem N\u00fcchterninsulin zusammen (Rs = 0,81).<sup>[2]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Alter und Geschlecht<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Bei Frauen ohne bekannte St\u00f6rung der Blutzuckerregulation hing die Genauigkeit von HOMA-IR mit dem Alter zusammen. Bei M\u00e4nnern war das nicht so.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Die Pr\u00e4zision des Modells<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Das Modell hat eine begrenzte Pr\u00e4zision: Der Variationskoeffizient betr\u00e4gt 31% f\u00fcr Insulinresistenz. Laut den Forschenden schr\u00e4nkt das die Verwendung der Sch\u00e4tzung ein.<sup>[2]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-welke-pakketten\">Welche BioProfile-Pakete HOMA-IR messen<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">HOMA-IR ist in BioProfile 121 und 150 enthalten.<sup>[3]<\/sup><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/bioprofile.com\/de\/blutuntersuchung\/\">Die Pakete ansehen<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarden-die-erbij-horen\">Werte, die dazugeh\u00f6ren<\/h2>\n\n\n\n<ul class=\"wp-block-list bp-bm-related\">\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/hba1c\/\">HbA1c<\/a>: ein weiterer Wert zu Ihrem Blutzucker, neben der N\u00fcchternglukose, mit der HOMA-IR berechnet wird.<sup>[2]<\/sup><\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/triglyceride\/\">Triglyceride<\/a>: ein Fettwert in Ihrem Blut, der zum breiteren Bild des Stoffwechselrisikos passt, bei dem HOMA-IR hilft.<sup>[1]<\/sup><\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/harnsaeure\/\">Harns\u00e4ure<\/a>: ein Stoffwechselwert, den Sie neben HOMA-IR betrachten, um ein breiteres Bild Ihres Stoffwechsels zu erhalten.<sup>[1]<\/sup><\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/ketone-im-urin\/\">Ketone (Urin)<\/a>: ein Wert aus Ihrem Urin, der neben Ihrer N\u00fcchternglukose und Ihrem Insulin etwas \u00fcber Ihren Stoffwechsel erg\u00e4nzt.<sup>[2]<\/sup><\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/glukose-urin\/\">Glukose (Urin)<\/a>: zeigt, ob sich Glukose in Ihrem Urin befindet, neben der N\u00fcchternglukose in Ihrem Blut, die HOMA-IR verwendet.<sup>[2]<\/sup><\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-hoe-gemaakt\">Wie diese Seite entstanden ist<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Die BioProfile Redaktion hat diese Seite am 10. Oktober 2026 auf Grundlage der unten genannten Quellen verfasst, die wir am 10. Oktober 2026 gelesen haben. Jede Zahl auf dieser Seite steht in einer dieser Quellen, mit der Nummer der jeweiligen Quelle dabei. Eine Fachperson pr\u00fcft diese Seite noch; nach dieser Pr\u00fcfung stehen der Name der Fachperson und das Datum der Pr\u00fcfung oben auf der Seite. Diese Seite dient der Erkl\u00e4rung und stellt keine Diagnose. Besprechen Sie einen auff\u00e4lligen Wert mit Ihrem Hausarzt.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--disclosure is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-bronnen\">Quellen<\/h2>\n\n\n\n<ol class=\"wp-block-list bp-adv-srclist bp-bm-src\">\n\n<li>Gayoso-Diz P, Otero-Gonz\u00e1lez A, Rodriguez-Alvarez MX, et al. Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study. BMC Endocr Disord. 2013;13:47. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24131857\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24131857\/<\/a><\/li>\n\n\n<li>Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3899825\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/3899825\/<\/a><\/li>\n\n\n<li>BioProfile, die Pakete der Blutuntersuchung und die Werte in jedem Paket. <a href=\"https:\/\/bioprofile.com\/de\/blutuntersuchung\/\" target=\"_blank\" rel=\"noopener\">https:\/\/bioprofile.com\/de\/blutuntersuchung\/<\/a><\/li>\n\n<\/ol>\n\n<\/div>\n\n<\/section>\n\n","protected":false},"excerpt":{"rendered":"<p>Startseite \u203a Biomarker \u203a HOMA-IR HOMA-IR: Was Ihr Wert \u00fcber Insulinresistenz aussagt In einer Zufallsstichprobe von 2459 spanischen Erwachsenen lag der Grenzwert f\u00fcr HOMA-IR bei 2,05. Das galt, als die Forschenden Merkmale betrachteten, die zusammen das Risiko f\u00fcr Stoffwechsel, Herz und Blutgef\u00e4\u00dfe erh\u00f6hen.[1] Auf dieser Seite lesen Sie, was HOMA-IR ist, was die Leitlinien \u00fcber [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":0,"parent":6596,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_yoast_wpseo_title":"HOMA-IR: Insulinresistenz aus Ihrem Blut | BioProfile","_yoast_wpseo_metadesc":"Was ist HOMA-IR, wie sch\u00e4tzt es die Insulinresistenz aus N\u00fcchternglukose und Insulin, und worauf kann ein hoher Wert hinweisen? 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