{"id":12904,"date":"2026-10-25T06:00:00","date_gmt":"2026-10-25T06:00:00","guid":{"rendered":"https:\/\/bioprofile.com\/?page_id=12904"},"modified":"2026-10-25T06:17:54","modified_gmt":"2026-10-25T06:17:54","slug":"sii","status":"publish","type":"page","link":"https:\/\/bioprofile.com\/de\/biomarkers\/sii\/","title":{"rendered":"Systemischer Immun-Inflammations-Index"},"content":{"rendered":"\n<div id=\"content\" tabindex=\"-1\"><\/div>\n<style>@import url('https:\/\/fonts.googleapis.com\/css2?family=Poppins:ital,wght@0,400;0,600;0,700;0,800;1,400&display=swap');\n\/* ===========================================================================\n   BioProfile advertorial, the design Jesse approved on 2026-07-30, expressed\n   as a WordPress design system.\n\n   THE @import IS LOAD BEARING and must stay the first thing in this sheet (a\n   CSS @import after any rule is dropped by the parser). elementor_canvas does\n   not enqueue the theme's fonts, so without it the whole page falls back to the\n   system font. Caught by LOOKING at the live page on 2026-07-30, right after\n   the template was switched to canvas.\n\n   Everything is scoped to `.bp-adv`, so nothing here can reach the rest of\n   bioprofile.com, and core blocks are styled BY ELEMENT so a heading, a\n   paragraph, a quote, a list, an image or a button inserted by hand inside the\n   advertorial comes out on-design with no class to remember.\n\n   Jesse's design feedback, 2026-07-29 23:38, point by point:\n   1. the light green and the dark green are the preferred colours; grey may be\n      used but the page must NOT open grey;\n   2. more colour and variation across sections, e.g. a colour block on the left\n      or the right side of a section, without overdesign;\n   3. ONE H1, plain text on white; everything else H2 or H3; an H2 may carry its\n      own background colour so the page can be read from the headings alone; an\n      H3 keeps its section background and gets a bigger font size;\n   4. reuse the results page design feel;\n   5. Written by \/ Verified by, the placeholder blocks and noindex stay.\n\n   COLOUR PROVENANCE. Not one hex is invented.\n   - #b7cb32  LIGHT GREEN, brand manual \"colours rejuvenation protocol\"\n              (R183 G203 B51). Same value as --bp-lime in\n              brands\/bioprofile\/brand\/tokens.md.\n   - #006b62  DARK GREEN, brand manual, nourish the cells (R0 G107 B98).\n   - #005859  brand manual primary teal, the value the brand is built on.\n   - #228a62  brand manual, challenge the body (R34 G138 B98).\n   - #7ca64c  brand manual, calm the mind (R124 G166 B76).\n   - #dbd4cd  brand manual \"additional color\", the warm neutral.\n   - #B7CB3329 is the brand token --bp-lime-soft (light green at 16 percent).\n   - the gradients are the brand token layer's own, copied verbatim.\n\n   SPECIFICITY NOTE. Elementor's global kit emits `.elementor-kit-6 h2` style\n   rules at (0,1,1). Element rules below are written `.bp-adv h2`, also (0,1,1),\n   and win on source order because this sheet is inline in the body while the\n   kit is a <link> in the head. Component rules that MUST NOT lose carry two\n   classes, e.g. `.bp-adv .wp-block-button__link`.\n\n   LAYOUT NOTE. Vertical rhythm uses `margin-block` and never the `margin`\n   shorthand, so the measure rule `.bp-adv-sec > * { margin-inline: auto }` can\n   centre a block without being outranked by its own element rule.\n   =========================================================================== *\/\n\n.bp-adv {\n  --bp-ink: #212527;\n  --bp-teal: #005859;\n  --bp-forest: #006B62;\n  --bp-emerald: #228A62;\n  --bp-olive: #7CA64C;\n  --bp-lime: #B7CB33;\n  --bp-lime-soft: #B7CB3329;\n  --bp-sand: #DBD4CB;\n  --bp-white: #FFFFFF;\n  --bp-foot: #6b6b6b;\n  --bp-grad-dark: linear-gradient(237deg, rgba(0,88,89,0.00) 62.94%, #005859 100%), linear-gradient(90deg, rgba(34,138,98,0.00) 40%, #228A62 100%), #006B62;\n  --bp-grad-lime: linear-gradient(110deg, rgba(183,203,51,0.00) 36.06%, rgba(183,203,51,0.25) 97.65%), #FFFFFF;\n  --bp-font: 'Poppins','Segoe UI',Arial,sans-serif;\n  --bp-fs-h1: 44px; --bp-fs-h2: 31px; --bp-fs-h3: 24px; --bp-fs-pre: 15px;\n  --bp-fs-body: 17px; --bp-fs-small: 14px; --bp-fs-foot: 13px; --bp-fs-btn: 17px;\n  --bp-lh-body: 1.75;\n  --bp-s-1: 4px; --bp-s-2: 8px; --bp-s-3: 12px; --bp-s-4: 16px;\n  --bp-s-5: 24px; --bp-s-6: 32px; --bp-s-7: 44px; --bp-s-8: 72px;\n  --bp-measure: 760px; --bp-side: 40px;\n  --bp-radius-photo: 16px; --bp-radius-btn: 10px; --bp-radius-card: 20px;\n  --bp-shadow: 0 10px 30px rgba(0,88,89,0.10);\n  font-family: var(--bp-font);\n  font-size: var(--bp-fs-body);\n  line-height: var(--bp-lh-body);\n  color: var(--bp-ink);\n  background: var(--bp-white);\n  -webkit-font-smoothing: antialiased;\n}\n.bp-adv, .bp-adv * { box-sizing: border-box; }\n.bp-adv p, .bp-adv li, .bp-adv h1, .bp-adv h2, .bp-adv h3, .bp-adv blockquote,\n.bp-adv a, .bp-adv cite, .bp-adv span { overflow-wrap: break-word; min-width: 0; }\n\n\/* THE TOGGLE. One word in the block's own \"Additional CSS class(es)\" field\n   hides an optional component on the front end without deleting anything. *\/\n.bp-adv .bp-off { display: none !important; }\n\n\/* the page opens on green, never on grey (his point 1) *\/\n.bp-adv .bp-adv-rule {\n  height: 6px; border: 0; margin-block: 0; max-width: none;\n  background: linear-gradient(90deg, #005859 0%, #006B62 38%, #228A62 66%, #B7CB33 100%);\n}\n\n\/* --- section surfaces ------------------------------------------------------ *\/\n.bp-adv-sec { position: relative; background: var(--bp-white);\n  padding: var(--bp-s-8) var(--bp-side); margin-block: 0; }\n\/* the measure: every direct child of a section is the 760px text column *\/\n.bp-adv-sec > * { max-width: var(--bp-measure); margin-inline: auto; }\n.bp-adv-sec > *:last-child { margin-block-end: 0; }\n.bp-adv-sec--wash  { background: linear-gradient(180deg, #B7CB331F 0%, #B7CB3312 100%), #FFFFFF; }\n.bp-adv-sec--dark  { background: var(--bp-grad-dark); color: var(--bp-white); }\n.bp-adv-sec--dark p, .bp-adv-sec--dark cite, .bp-adv-sec--dark li { color: var(--bp-white); }\n.bp-adv-sec--offer { background: var(--bp-grad-lime); text-align: center; }\n.bp-adv-sec--hero  { padding-block-start: var(--bp-s-6); }\n.bp-adv-sec--disclosure { padding-block: var(--bp-s-6);\n  border-top: 1px solid var(--bp-sand); }\n\n\/* --- the side accent bar, his own example (\"a colour block on the left or the\n       right side of a section\"), design rev 3: a slim vertical bar hugging the\n       text column rather than a wide margin panel. Below 1100px the margin is\n       gone, so it becomes a slim top edge. ---------------------------------- *\/\n.bp-adv-rail { overflow: hidden; }\n.bp-adv-rail::before {\n  content: \"\"; position: absolute; top: var(--bp-s-7); bottom: var(--bp-s-7);\n  width: 6px; border-radius: 3px;\n  background: linear-gradient(180deg, var(--bp-forest) 0%, var(--bp-lime) 100%);\n}\n.bp-adv-rail--left::before  { left: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n.bp-adv-rail--right::before { right: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n@media (max-width: 1099px) {\n  .bp-adv-rail::before { left: 0; right: 0; width: auto; bottom: auto; top: 0;\n    height: 4px; border-radius: 0; background: var(--bp-lime); }\n}\n\n\/* --- CORE BLOCKS, styled by element. This is the part that makes an inserted\n       block come out on-design with no class. --------------------------------- *\/\n.bp-adv p { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv h1 { font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); }\n\/* an H2 is its own colour band, so the page can be read from the headings\n   alone (his point 3). Dark green on light sections, light green on the dark\n   one, so a heading always wins against its own background. *\/\n.bp-adv h2 {\n  font-size: var(--bp-fs-h2); font-weight: 700; line-height: 1.28;\n  margin-block: 0 var(--bp-s-5);\n  background: var(--bp-grad-dark); color: var(--bp-white);\n  padding: var(--bp-s-4) var(--bp-s-5);\n  border-radius: var(--bp-radius-btn);\n  border-left: 6px solid var(--bp-lime);\n}\n.bp-adv-sec--dark h2 { background: var(--bp-lime); color: var(--bp-ink);\n  border-left-color: var(--bp-forest); }\n\/* H3: same background as its section, bigger font (his point 3, verbatim) *\/\n.bp-adv h3 { font-size: var(--bp-fs-h3); font-weight: 700; line-height: 1.35;\n  color: var(--bp-forest); background: transparent; margin-block: 0 var(--bp-s-3); }\n.bp-adv-sec--dark h3 { color: var(--bp-lime); }\n.bp-adv ul, .bp-adv ol { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); padding-left: var(--bp-s-5); }\n.bp-adv li { margin-block-end: var(--bp-s-2); }\n.bp-adv a { color: var(--bp-teal); text-decoration: underline; }\n.bp-adv a:hover { color: var(--bp-olive); }\n.bp-adv-sec--dark a, .bp-adv-sec--dark strong { color: var(--bp-lime); }\n.bp-adv strong { font-weight: 700; }\n\/* the highlight pill. Colours ride on the inline style core writes, so only\n   the shape lives here and any <mark> in the article picks it up. *\/\n.bp-adv mark {\n  padding: 0 10px; border-radius: 10px; display: inline;\n  -webkit-box-decoration-break: clone; box-decoration-break: clone;\n}\n\/* figures match the approved page exactly: card radius plus the soft shadow,\n   and a left-aligned caption rather than core's centred one *\/\n.bp-adv .wp-block-image { margin-block: var(--bp-s-5); margin-inline: auto; }\n.bp-adv .wp-block-image img { display: block; width: 100%; height: auto;\n  border-radius: var(--bp-radius-card); box-shadow: var(--bp-shadow); }\n.bp-adv .wp-block-image figcaption { font-size: var(--bp-fs-foot); line-height: 1.55;\n  color: var(--bp-foot); text-align: left; margin-block: var(--bp-s-2) 0; }\n.bp-adv .wp-block-embed, .bp-adv .wp-block-video { margin-block: var(--bp-s-5); }\n.bp-adv .wp-block-embed iframe, .bp-adv .wp-block-video video {\n  width: 100%; border-radius: var(--bp-radius-photo); }\n.bp-adv .wp-block-separator:not(.bp-adv-rule) { border: 0; border-top: 1px solid var(--bp-sand);\n  margin-block: var(--bp-s-5); }\n\n\/* quotes: core pullquote and core quote both land on the lime rule. The\n   font-size reset undoes core's own 1.5em on the figure, which would otherwise\n   leak into anything inside the quote that has no size of its own. *\/\n\/* margin-inline is load bearing, and it must be `auto` rather than `0`.\n   `blockquote` and `figure` carry a 40px side margin in the browser's own\n   default stylesheet, which indents the quote inside its rule and makes the\n   copy wrap early on a phone. But these blocks are direct children of a\n   section, so zeroing the side margin also defeats the measure rule\n   `.bp-adv-sec > * { margin-inline: auto }` and pins them to the left edge. *\/\n.bp-adv .wp-block-pullquote, .bp-adv .wp-block-quote {\n  border: 0; border-left: 5px solid var(--bp-lime); background: transparent;\n  padding: var(--bp-s-2) 0 var(--bp-s-2) var(--bp-s-5);\n  margin-block: var(--bp-s-5); margin-inline: auto;\n  text-align: left; font-size: var(--bp-fs-body);\n}\n.bp-adv .wp-block-pullquote blockquote { border: 0; margin: 0; padding: 0; }\n.bp-adv .wp-block-pullquote p, .bp-adv .wp-block-quote p {\n  font-size: 24px; line-height: 1.45; font-weight: 600;\n  margin-block: 0 var(--bp-s-2); color: var(--bp-forest); }\n.bp-adv .wp-block-pullquote cite, .bp-adv .wp-block-quote cite {\n  display: block; margin: 0; font-size: var(--bp-fs-small); color: var(--bp-foot);\n  font-style: normal; text-transform: none; }\n\n\/* buttons: two classes so core's own .wp-block-button__link cannot win *\/\n.bp-adv .wp-block-buttons { display: flex; justify-content: center;\n  margin-block: 0 var(--bp-s-4); }\n.bp-adv .wp-block-button__link {\n  display: inline-flex; align-items: center; justify-content: center; min-height: 48px;\n  background: var(--bp-teal); color: var(--bp-white); font-size: var(--bp-fs-btn);\n  font-weight: 700; line-height: 1.2; border-radius: var(--bp-radius-btn);\n  padding: 15px 44px; text-decoration: none; transition: background 250ms ease;\n  box-shadow: var(--bp-shadow);\n}\n.bp-adv .wp-block-button__link:hover { background: var(--bp-olive); color: var(--bp-white); }\n\n\/* --- slot 1: pre-headline, headline, sub-headline (Jesse's headline skill) --- *\/\n.bp-adv .bp-adv-preheadline {\n  color: var(--bp-forest); font-size: var(--bp-fs-pre); font-weight: 600; line-height: 1.5;\n  border-left: 4px solid var(--bp-lime); padding-left: var(--bp-s-3);\n  margin-block: 0 var(--bp-s-4);\n}\n.bp-adv .bp-adv-subheadline { font-size: 21px; line-height: 1.5; font-weight: 600;\n  color: var(--bp-forest); margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-standfirst { font-size: 19px; line-height: 1.65;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-lede { font-size: 18px; line-height: 1.7;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-byline { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  line-height: 1.6; margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-socialproof { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  margin-block: 0 var(--bp-s-5); }\n\/* the offer headline above the CTA. Jesse asked for a second H1 here; the brand\n   doc's accessibility rule is one h1 per page, so it is rendered at H1 size and\n   stays an h2 element. Named in the close as the one design conflict. *\/\n.bp-adv h2.bp-adv-offerhead {\n  font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); text-align: center; color: var(--bp-ink);\n  background: none; padding: 0; border: 0; border-radius: 0;\n}\n\n\/* --- Written by + Verified by. The avatar is the first child and spans the\n       three text rows, so the whole box is four ordinary paragraphs and stays\n       editable without nested columns. ---------------------------------------- *\/\n.bp-adv .bp-adv-authors {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-top: 4px solid var(--bp-lime); border-radius: var(--bp-radius-card);\n  box-shadow: var(--bp-shadow); padding: var(--bp-s-5);\n  margin-block: 0 var(--bp-s-4);\n  \/* auto-fit, so switching the verified box off leaves one full-width author\n     rather than a half-empty card *\/\n  display: grid; grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));\n  gap: var(--bp-s-5); align-items: start;\n}\n.bp-adv .bp-adv-author {\n  display: grid; grid-template-columns: 62px 1fr; gap: 0 var(--bp-s-3);\n  align-items: start; min-width: 0;\n}\n.bp-adv .bp-adv-avatar {\n  grid-row: 1 \/ span 3; width: 62px; height: 62px; border-radius: 50%;\n  background: #B7CB331F; border: 2px dashed var(--bp-olive);\n  display: flex; align-items: center; justify-content: center;\n  font-size: 10px; font-weight: 700; letter-spacing: 0.06em; color: var(--bp-forest);\n  margin-block: 0;\n}\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-avatar {\n  border-color: var(--bp-sand); background: #fff; color: var(--bp-foot); }\n.bp-adv .bp-adv-author-role {\n  font-size: 11px; font-weight: 700; letter-spacing: 0.08em; text-transform: uppercase;\n  color: var(--bp-forest); line-height: 1.6; margin-block: 0; }\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-author-role { color: var(--bp-foot); }\n.bp-adv .bp-adv-author-name { font-size: 17px; font-weight: 700; line-height: 1.35;\n  margin-block: 0; }\n.bp-adv .bp-adv-author-cred { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.55; margin-block: 0; }\n\/* the optional wrapper must not break the two-column grid of the box *\/\n.bp-adv .bp-adv-authors > .bp-optional { display: contents; }\n.bp-adv .bp-adv-authors > .bp-optional.bp-off { display: none !important; }\n\n\/* --- placeholders: image slot, video slot ---------------------------------- *\/\n.bp-adv .bp-slot {\n  display: flex; align-items: center; justify-content: center; text-align: center;\n  min-height: 180px; padding: var(--bp-s-4); margin-block: var(--bp-s-5) 0;\n  border: 2px dashed var(--bp-olive); border-radius: var(--bp-radius-photo);\n  background: #B7CB331F; color: var(--bp-forest);\n}\n.bp-adv .bp-slot p { font-size: var(--bp-fs-small); font-weight: 700; margin-block: 0; }\n.bp-adv .bp-slot--video { min-height: 260px; }\n\n\/* --- mid-article CTA band --------------------------------------------------- *\/\n.bp-adv .bp-adv-midcta {\n  background: var(--bp-grad-lime); border: 1px solid var(--bp-lime);\n  border-radius: var(--bp-radius-card); padding: var(--bp-s-5) var(--bp-s-4);\n  margin-block: var(--bp-s-6); text-align: center;\n}\n.bp-adv .bp-adv-midcta .wp-block-buttons { margin-block-end: var(--bp-s-2); }\n.bp-adv .bp-adv-midcta .bp-adv-foot { margin-block: 0; }\n\n\/* the closing CTA is one named unit in List View, so it moves and toggles as a\n   whole. It carries no box of its own: the spacing must read exactly as it does\n   on the approved page, where the three parts are plain siblings. *\/\n.bp-adv .bp-adv-ctablock { margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-ctablock .wp-block-buttons { margin-block-end: var(--bp-s-4); }\n.bp-adv .bp-adv-ctablock .bp-adv-foot { margin-block: 0; }\n\n\/* --- the condition, slot 8: the results page reference-card shape ----------- *\/\n.bp-adv .bp-adv-condition {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-left: 5px solid var(--bp-lime); border-radius: var(--bp-radius-btn);\n  padding: var(--bp-s-4) var(--bp-s-5); font-weight: 600; box-shadow: var(--bp-shadow);\n}\n\n\/* --- the numbers card: the results page focus panel, same gradient, same\n       radius, same lime figures (\"use more of that design\") ------------------ *\/\n.bp-adv .bp-adv-numcard {\n  background: linear-gradient(135deg, var(--bp-teal) 0%, var(--bp-forest) 100%);\n  border-radius: var(--bp-radius-card);\n  padding: var(--bp-s-6) var(--bp-s-5) var(--bp-s-5);\n  box-shadow: var(--bp-shadow); margin-block: var(--bp-s-5) 0;\n  position: relative; overflow: hidden;\n}\n.bp-adv .bp-adv-numcard::after {\n  content: \"\"; position: absolute; right: -70px; top: -70px; width: 240px; height: 240px;\n  border-radius: 50%; background: rgba(255,255,255,0.05); pointer-events: none;\n}\n.bp-adv .bp-adv-numcard .wp-block-columns {\n  position: relative; z-index: 1; gap: var(--bp-s-5); margin-block: 0; }\n.bp-adv .bp-adv-numcard .wp-block-column { min-width: 0; }\n.bp-adv .bp-adv-num-v { font-size: 44px; font-weight: 700; line-height: 1.12;\n  color: var(--bp-lime); text-align: center; margin-block: 0 var(--bp-s-2); }\n.bp-adv .bp-adv-num-l { font-size: var(--bp-fs-small); line-height: 1.5;\n  color: rgba(255,255,255,0.92); text-align: center; margin-block: 0; }\n.bp-adv .bp-adv-numsrc { margin-block: var(--bp-s-5) 0; }\n\n\/* --- the proof slot: a dashed card until a consented quote exists. 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Clin Cancer Res. 2014;20(23):6212-22.\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25271081\/\"},{\"@type\":\"CreativeWork\",\"name\":\"BioProfile, de pakketten van het bloedonderzoek en de waarden in elk pakket.\",\"url\":\"https:\/\/bioprofile.com\/bloedonderzoek\/\"}]},{\"@type\":\"MedicalTest\",\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/sii\/#biomarker\",\"name\":\"Systemische immuun-ontstekingsindex\",\"alternateName\":[\"Systemic immune-inflammation index\"]}]}<\/script>\n\n\n\n<section class=\"wp-block-group bp-adv bp-biomarker bp-biomarker--page is-layout-flow wp-block-group-is-layout-flow\">\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity bp-adv-rule\"\/>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--hero is-layout-flow wp-block-group-is-layout-flow\">\n\n<p class=\"bp-bm-crumbs wp-block-paragraph\"><a href=\"https:\/\/bioprofile.com\/de\/\">Home<\/a> \u203a <a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/\">Biomarker<\/a> \u203a <span>Systemischer Immun-Inflammations-Index<\/span><\/p>\n\n\n\n<h1 class=\"wp-block-heading bp-adv-h1\">Systemischer Immun-Inflammations-Index (SII)<\/h1>\n\n\n\n<p class=\"bp-adv-standfirst wp-block-paragraph\">Bei Menschen mit einer Erkrankung der Leber, die operiert worden waren, legten die Forschenden die Grenze bei 330 fest. Ein Wert von 330 oder h\u00f6her hing in dieser Gruppe mit einem weniger g\u00fcnstigen Verlauf zusammen.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"bp-adv-lede wp-block-paragraph\">Auf dieser Seite lesen Sie, was der systemische Immun-Inflammations-Index ist, was die Leitlinien \u00fcber einen zu niedrigen oder zu hohen Wert sagen, was Ihren Wert beeinflusst und welche Werte Sie am besten daneben legen.<\/p>\n\n\n\n<p class=\"bp-bm-names wp-block-paragraph\">Auch: SII, Immun-Inflammations-Index. Beim Labor: entf\u00e4llt.<\/p>\n\n\n\n<p class=\"bp-adv-byline wp-block-paragraph\">Aktualisiert am 23. Oktober 2026<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-group bp-bm-toc is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-inhoud\">Auf dieser Seite<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li><a href=\"#bp-in-het-kort\">Kurz gefasst<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-is-sii\">Was ist der systemische Immun-Inflammations-Index?<\/a><\/li>\n\n\n<li><a href=\"#bp-waarom-het-ertoe-doet\">Warum dieser Wert wichtig ist<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-je-waarde-zegt\">Was Ihr systemischer Immun-Inflammations-Index aussagt<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-het-beinvloedt\">Was Ihren systemischen Immun-Inflammations-Index beeinflusst<\/a><\/li>\n\n\n<li><a href=\"#bp-welke-pakketten\">Welche BioProfile-Pakete den systemischen Immun-Inflammations-Index messen<\/a><\/li>\n\n\n<li><a href=\"#bp-waarden-die-erbij-horen\">Werte, die dazugeh\u00f6ren<\/a><\/li>\n\n\n<li><a href=\"#bp-hoe-gemaakt\">Wie diese Seite entstanden ist<\/a><\/li>\n\n\n<li><a href=\"#bp-bronnen\">Quellen<\/a><\/li>\n\n<\/ul>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-in-het-kort\">Kurz gefasst<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li>Der Index wurde bei 133 Menschen mit einer Erkrankung der Leber entwickelt und danach bei 123 Menschen \u00fcberpr\u00fcft.<sup>[1]<\/sup><\/li>\n\n\n<li>In dieser Studie kann ein Wert von 330 oder h\u00f6her auf einen weniger g\u00fcnstigen Verlauf hinweisen.<sup>[1]<\/sup><\/li>\n\n\n<li>In dieser Gruppe sch\u00e4tzte der Index das \u00dcberleben und die R\u00fcckkehr der Erkrankung besser ein als andere g\u00e4ngige Ma\u00dfe.<sup>[1]<\/sup><\/li>\n\n\n<li>Die Studie befasste sich nur mit Menschen nach einer Operation an der Leber, daher gilt die Grenze f\u00fcr diese Gruppe.<sup>[1]<\/sup><\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-is-sii\">Was ist der systemische Immun-Inflammations-Index?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Der systemische Immun-Inflammations-Index ist ein berechneter Wert, der drei Arten von Blutzellen in einer Zahl zusammenf\u00fchrt. Es geht um Lymphozyten, Neutrophile und Blutpl\u00e4ttchen. Diese Zellen werden in Ihrem Blut gez\u00e4hlt. Aus diesen Z\u00e4hlwerten wird der Index berechnet.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Forschende entwickelten diesen Index bei Menschen mit einer Erkrankung der Leber, die an der Leber operiert worden waren. Bei ihnen hing ein hoher Index mit einem weniger g\u00fcnstigen Verlauf zusammen. Ein hoher Wert kann in dieser Gruppe also auf ein h\u00f6heres Risiko hinweisen, dass die Erkrankung zur\u00fcckkehrt.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Diese Studie befasste sich mit einer bestimmten Gruppe von Patienten. Dort wurde der Index vor allem als Hilfsmittel untersucht, um den weiteren Verlauf einzusch\u00e4tzen.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarom-het-ertoe-doet\">Warum dieser Wert wichtig ist<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In der Studie sagte der Index das \u00dcberleben und die Zeit ohne R\u00fcckkehr der Erkrankung voraus. Das blieb so, auch wenn die Forschenden andere Merkmale ber\u00fccksichtigten.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ein Wert von 330 oder h\u00f6her hing mit einem Wachstum der Erkrankung in die Blutgef\u00e4\u00dfe, mit gr\u00f6\u00dferen Ver\u00e4nderungen in der Leber und mit einer fr\u00fchen R\u00fcckkehr der Erkrankung zusammen.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Die Forschenden sehen den Index als vielversprechendes Hilfsmittel bei Entscheidungen in der Versorgung dieser Gruppe. Die Studie befasste sich mit Menschen mit einer Erkrankung der Leber, nicht mit allen Menschen.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-je-waarde-zegt\">Was Ihr systemischer Immun-Inflammations-Index aussagt<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Die Studie von Hu et al.<\/h3>\n\n\n\n<figure class=\"wp-block-table bp-bm-table\"><table><thead><tr><th>Wert<\/th><th>Kann hinweisen auf<\/th><th>F\u00fcr wen<\/th><\/tr><\/thead><tbody><tr><td>330 oder h\u00f6her<sup>[1]<\/sup><\/td><td>ein weniger g\u00fcnstiger Verlauf und eine fr\u00fche Wiederkehr der Erkrankung<\/td><td>Menschen mit einer Erkrankung der Leber nach einer Operation an der Leber<\/td><\/tr><tr><td>niedriger als 330<sup>[1]<\/sup><\/td><td>ein g\u00fcnstigerer Verlauf als in der Gruppe mit einem hohen Wert<\/td><td>Menschen mit einer Erkrankung der Leber nach einer Operation an der Leber<\/td><\/tr><tr><td>330 oder h\u00f6her, mit Zellen der Erkrankung im Blut<sup>[1]<\/sup><\/td><td>h\u00e4ufiger eine Wiederkehr der Erkrankung und ein k\u00fcrzeres \u00dcberleben<\/td><td>Menschen aus dieser Gruppe, bei denen solche Zellen im Blut gefunden wurden<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"bp-bm-caption wp-block-paragraph\">Quelle: Hu et al., 2014. Untersucht bei Menschen mit einer Erkrankung der Leber nach einer Operation an der Leber. Diese Grenze gilt f\u00fcr diese Gruppe.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Systemischer Immun-Inflammations-Index zu hoch<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Bei Menschen mit einer Erkrankung der Leber nach einer Operation kann ein Wert von 330 oder h\u00f6her auf einen weniger g\u00fcnstigen Verlauf hinweisen. Er kann auch auf ein h\u00f6heres Risiko hinweisen, dass die Erkrankung fr\u00fch zur\u00fcckkehrt. F\u00fcr andere Gruppen nennt diese Studie keine Grenze.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BioProfile arbeitet an eigenen Zonen pro Wert, von Risiko bis optimal. Ein Arzt pr\u00fcft diese Zonen, bevor sie in Ihrem Ergebnis erscheinen.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-het-beinvloedt\">Was Ihren systemischen Immun-Inflammations-Index beeinflusst<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Die Z\u00e4hlwerte von drei Zellarten<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Der Index ergibt sich aus den Z\u00e4hlwerten von Neutrophilen, Lymphozyten und Blutpl\u00e4ttchen. \u00c4ndert sich einer dieser Z\u00e4hlwerte, \u00e4ndert sich auch der Index.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Eine Erkrankung der Leber<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In der Studie kam ein hoher Index h\u00e4ufiger bei Menschen vor, bei denen die Erkrankung in die Blutgef\u00e4\u00dfe gewachsen war. Das galt auch bei gr\u00f6\u00dferen Ver\u00e4nderungen in der Leber.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Zellen der Erkrankung im Blut<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In der Gruppe mit einem Wert von 330 oder h\u00f6her fanden die Forschenden mehr Zellen der Erkrankung, die im Blut zirkulierten. Nach Einsch\u00e4tzung der Forschenden h\u00e4ngt der weniger g\u00fcnstige Verlauf bei einem hohen Index m\u00f6glicherweise damit zusammen.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-welke-pakketten\">Welche BioProfile-Pakete den systemischen Immun-Inflammations-Index messen<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Der systemische Immun-Inflammations-Index ist in allen f\u00fcnf Paketen enthalten, von BioProfile 31 bis BioProfile 150.<sup>[2]<\/sup><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/bioprofile.com\/de\/blutuntersuchung\/\">Die Pakete ansehen<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarden-die-erbij-horen\">Werte, die dazugeh\u00f6ren<\/h2>\n\n\n\n<ul class=\"wp-block-list bp-bm-related\">\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/leukozyten\/\">Leukozyten<\/a>: die Gesamtzahl der wei\u00dfen Blutk\u00f6rperchen, zu denen Neutrophile und Lymphozyten geh\u00f6ren.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/hs-crp\/\">CRP (hochsensitiv)<\/a>: ein anderes Ma\u00df f\u00fcr Entz\u00fcndung in Ihrem Blut, das Sie neben diesen Index legen k\u00f6nnen.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/lymphozyten\/\">Lymphozyten<\/a>: einer der drei Z\u00e4hlwerte, aus denen der Index berechnet wird.<sup>[1]<\/sup><\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/eosinophile\/\">Eosinophile Granulozyten<\/a>: eine andere Art wei\u00dfer Blutk\u00f6rperchen, die nicht in den Index eingeht.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/monozyten\/\">Monozyten<\/a>: eine andere Art wei\u00dfer Blutk\u00f6rperchen, die neben den Zellen des Index das Bild Ihrer Abwehr erg\u00e4nzt.<\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-hoe-gemaakt\">Wie diese Seite entstanden ist<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Die BioProfile-Redaktion hat diese Seite am 23. Oktober 2026 auf Grundlage der unten genannten Quellen geschrieben, die wir am 23. Oktober 2026 gelesen haben. Jede Zahl auf dieser Seite steht in einer dieser Quellen, mit der Nummer der jeweiligen Quelle. Eine fachkundige Person pr\u00fcft diese Seite noch; nach dieser Pr\u00fcfung stehen der Name der pr\u00fcfenden Fachperson und das Datum der Pr\u00fcfung oben auf der Seite. Diese Seite dient der Erkl\u00e4rung und stellt keine Diagnose. Besprechen Sie einen abweichenden Wert mit Ihrem Hausarzt.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--disclosure is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-bronnen\">Quellen<\/h2>\n\n\n\n<ol class=\"wp-block-list bp-adv-srclist bp-bm-src\">\n\n<li>Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212-22. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25271081\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/25271081\/<\/a><\/li>\n\n\n<li>BioProfile, die Pakete der Blutuntersuchung und die Werte in jedem Paket. <a href=\"https:\/\/bioprofile.com\/de\/blutuntersuchung\/\" target=\"_blank\" rel=\"noopener\">https:\/\/bioprofile.com\/de\/blutuntersuchung\/<\/a><\/li>\n\n<\/ol>\n\n<\/div>\n\n<\/section>\n\n","protected":false},"excerpt":{"rendered":"<p>Home \u203a Biomarker \u203a Systemischer Immun-Inflammations-Index Systemischer Immun-Inflammations-Index (SII) Bei Menschen mit einer Erkrankung der Leber, die operiert worden waren, legten die Forschenden die Grenze bei 330 fest. Ein Wert von 330 oder h\u00f6her hing in dieser Gruppe mit einem weniger g\u00fcnstigen Verlauf zusammen.[1] Auf dieser Seite lesen Sie, was der systemische Immun-Inflammations-Index ist, was [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":0,"parent":6596,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_yoast_wpseo_title":"Systemischer Immun-Inflammations-Index (SII) | BioProfile","_yoast_wpseo_metadesc":"Was der systemische Immun-Inflammations-Index ist, was die Forschung \u00fcber einen hohen Wert sagt und welche Werte Sie am besten daneben legen.","_yoast_wpseo_meta-robots-noindex":"2","_yoast_wpseo_opengraph-image":"","_yoast_wpseo_opengraph-image-id":"","_yoast_wpseo_twitter-image":"","_yoast_wpseo_twitter-image-id":"","inline_featured_image":false,"footnotes":""},"class_list":["post-12904","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO 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