{"id":13709,"date":"2026-10-28T06:00:00","date_gmt":"2026-10-28T06:00:00","guid":{"rendered":"https:\/\/bioprofile.com\/?page_id=13709"},"modified":"2026-11-05T22:34:15","modified_gmt":"2026-11-05T22:34:15","slug":"apri","status":"publish","type":"page","link":"https:\/\/bioprofile.com\/de\/biomarkers\/apri\/","title":{"rendered":"APRI-Score"},"content":{"rendered":"\n<div id=\"content\" tabindex=\"-1\"><\/div>\n<style>@import url('https:\/\/fonts.googleapis.com\/css2?family=Poppins:ital,wght@0,400;0,600;0,700;0,800;1,400&display=swap');\n\/* ===========================================================================\n   BioProfile advertorial, the design Jesse approved on 2026-07-30, expressed\n   as a WordPress design system.\n\n   THE @import IS LOAD BEARING and must stay the first thing in this sheet (a\n   CSS @import after any rule is dropped by the parser). elementor_canvas does\n   not enqueue the theme's fonts, so without it the whole page falls back to the\n   system font. Caught by LOOKING at the live page on 2026-07-30, right after\n   the template was switched to canvas.\n\n   Everything is scoped to `.bp-adv`, so nothing here can reach the rest of\n   bioprofile.com, and core blocks are styled BY ELEMENT so a heading, a\n   paragraph, a quote, a list, an image or a button inserted by hand inside the\n   advertorial comes out on-design with no class to remember.\n\n   Jesse's design feedback, 2026-07-29 23:38, point by point:\n   1. the light green and the dark green are the preferred colours; grey may be\n      used but the page must NOT open grey;\n   2. more colour and variation across sections, e.g. a colour block on the left\n      or the right side of a section, without overdesign;\n   3. ONE H1, plain text on white; everything else H2 or H3; an H2 may carry its\n      own background colour so the page can be read from the headings alone; an\n      H3 keeps its section background and gets a bigger font size;\n   4. reuse the results page design feel;\n   5. Written by \/ Verified by, the placeholder blocks and noindex stay.\n\n   COLOUR PROVENANCE. Not one hex is invented.\n   - #b7cb32  LIGHT GREEN, brand manual \"colours rejuvenation protocol\"\n              (R183 G203 B51). Same value as --bp-lime in\n              brands\/bioprofile\/brand\/tokens.md.\n   - #006b62  DARK GREEN, brand manual, nourish the cells (R0 G107 B98).\n   - #005859  brand manual primary teal, the value the brand is built on.\n   - #228a62  brand manual, challenge the body (R34 G138 B98).\n   - #7ca64c  brand manual, calm the mind (R124 G166 B76).\n   - #dbd4cd  brand manual \"additional color\", the warm neutral.\n   - #B7CB3329 is the brand token --bp-lime-soft (light green at 16 percent).\n   - the gradients are the brand token layer's own, copied verbatim.\n\n   SPECIFICITY NOTE. Elementor's global kit emits `.elementor-kit-6 h2` style\n   rules at (0,1,1). Element rules below are written `.bp-adv h2`, also (0,1,1),\n   and win on source order because this sheet is inline in the body while the\n   kit is a <link> in the head. Component rules that MUST NOT lose carry two\n   classes, e.g. `.bp-adv .wp-block-button__link`.\n\n   LAYOUT NOTE. Vertical rhythm uses `margin-block` and never the `margin`\n   shorthand, so the measure rule `.bp-adv-sec > * { margin-inline: auto }` can\n   centre a block without being outranked by its own element rule.\n   =========================================================================== *\/\n\n.bp-adv {\n  --bp-ink: #212527;\n  --bp-teal: #005859;\n  --bp-forest: #006B62;\n  --bp-emerald: #228A62;\n  --bp-olive: #7CA64C;\n  --bp-lime: #B7CB33;\n  --bp-lime-soft: #B7CB3329;\n  --bp-sand: #DBD4CB;\n  --bp-white: #FFFFFF;\n  --bp-foot: #6b6b6b;\n  --bp-grad-dark: linear-gradient(237deg, rgba(0,88,89,0.00) 62.94%, #005859 100%), linear-gradient(90deg, rgba(34,138,98,0.00) 40%, #228A62 100%), #006B62;\n  --bp-grad-lime: linear-gradient(110deg, rgba(183,203,51,0.00) 36.06%, rgba(183,203,51,0.25) 97.65%), #FFFFFF;\n  --bp-font: 'Poppins','Segoe UI',Arial,sans-serif;\n  --bp-fs-h1: 44px; --bp-fs-h2: 31px; --bp-fs-h3: 24px; --bp-fs-pre: 15px;\n  --bp-fs-body: 17px; --bp-fs-small: 14px; --bp-fs-foot: 13px; --bp-fs-btn: 17px;\n  --bp-lh-body: 1.75;\n  --bp-s-1: 4px; --bp-s-2: 8px; --bp-s-3: 12px; --bp-s-4: 16px;\n  --bp-s-5: 24px; --bp-s-6: 32px; --bp-s-7: 44px; --bp-s-8: 72px;\n  --bp-measure: 760px; --bp-side: 40px;\n  --bp-radius-photo: 16px; --bp-radius-btn: 10px; --bp-radius-card: 20px;\n  --bp-shadow: 0 10px 30px rgba(0,88,89,0.10);\n  font-family: var(--bp-font);\n  font-size: var(--bp-fs-body);\n  line-height: var(--bp-lh-body);\n  color: var(--bp-ink);\n  background: var(--bp-white);\n  -webkit-font-smoothing: antialiased;\n}\n.bp-adv, .bp-adv * { box-sizing: border-box; }\n.bp-adv p, .bp-adv li, .bp-adv h1, .bp-adv h2, .bp-adv h3, .bp-adv blockquote,\n.bp-adv a, .bp-adv cite, .bp-adv span { overflow-wrap: break-word; min-width: 0; }\n\n\/* THE TOGGLE. One word in the block's own \"Additional CSS class(es)\" field\n   hides an optional component on the front end without deleting anything. *\/\n.bp-adv .bp-off { display: none !important; }\n\n\/* the page opens on green, never on grey (his point 1) *\/\n.bp-adv .bp-adv-rule {\n  height: 6px; border: 0; margin-block: 0; max-width: none;\n  background: linear-gradient(90deg, #005859 0%, #006B62 38%, #228A62 66%, #B7CB33 100%);\n}\n\n\/* --- section surfaces ------------------------------------------------------ *\/\n.bp-adv-sec { position: relative; background: var(--bp-white);\n  padding: var(--bp-s-8) var(--bp-side); margin-block: 0; }\n\/* the measure: every direct child of a section is the 760px text column *\/\n.bp-adv-sec > * { max-width: var(--bp-measure); margin-inline: auto; }\n.bp-adv-sec > *:last-child { margin-block-end: 0; }\n.bp-adv-sec--wash  { background: linear-gradient(180deg, #B7CB331F 0%, #B7CB3312 100%), #FFFFFF; }\n.bp-adv-sec--dark  { background: var(--bp-grad-dark); color: var(--bp-white); }\n.bp-adv-sec--dark p, .bp-adv-sec--dark cite, .bp-adv-sec--dark li { color: var(--bp-white); }\n.bp-adv-sec--offer { background: var(--bp-grad-lime); text-align: center; }\n.bp-adv-sec--hero  { padding-block-start: var(--bp-s-6); }\n.bp-adv-sec--disclosure { padding-block: var(--bp-s-6);\n  border-top: 1px solid var(--bp-sand); }\n\n\/* --- the side accent bar, his own example (\"a colour block on the left or the\n       right side of a section\"), design rev 3: a slim vertical bar hugging the\n       text column rather than a wide margin panel. Below 1100px the margin is\n       gone, so it becomes a slim top edge. ---------------------------------- *\/\n.bp-adv-rail { overflow: hidden; }\n.bp-adv-rail::before {\n  content: \"\"; position: absolute; top: var(--bp-s-7); bottom: var(--bp-s-7);\n  width: 6px; border-radius: 3px;\n  background: linear-gradient(180deg, var(--bp-forest) 0%, var(--bp-lime) 100%);\n}\n.bp-adv-rail--left::before  { left: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n.bp-adv-rail--right::before { right: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n@media (max-width: 1099px) {\n  .bp-adv-rail::before { left: 0; right: 0; width: auto; bottom: auto; top: 0;\n    height: 4px; border-radius: 0; background: var(--bp-lime); }\n}\n\n\/* --- CORE BLOCKS, styled by element. This is the part that makes an inserted\n       block come out on-design with no class. --------------------------------- *\/\n.bp-adv p { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv h1 { font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); }\n\/* an H2 is its own colour band, so the page can be read from the headings\n   alone (his point 3). Dark green on light sections, light green on the dark\n   one, so a heading always wins against its own background. *\/\n.bp-adv h2 {\n  font-size: var(--bp-fs-h2); font-weight: 700; line-height: 1.28;\n  margin-block: 0 var(--bp-s-5);\n  background: var(--bp-grad-dark); color: var(--bp-white);\n  padding: var(--bp-s-4) var(--bp-s-5);\n  border-radius: var(--bp-radius-btn);\n  border-left: 6px solid var(--bp-lime);\n}\n.bp-adv-sec--dark h2 { background: var(--bp-lime); color: var(--bp-ink);\n  border-left-color: var(--bp-forest); }\n\/* H3: same background as its section, bigger font (his point 3, verbatim) *\/\n.bp-adv h3 { font-size: var(--bp-fs-h3); font-weight: 700; line-height: 1.35;\n  color: var(--bp-forest); background: transparent; margin-block: 0 var(--bp-s-3); }\n.bp-adv-sec--dark h3 { color: var(--bp-lime); }\n.bp-adv ul, .bp-adv ol { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); padding-left: var(--bp-s-5); }\n.bp-adv li { margin-block-end: var(--bp-s-2); }\n.bp-adv a { color: var(--bp-teal); text-decoration: underline; }\n.bp-adv a:hover { color: var(--bp-olive); }\n.bp-adv-sec--dark a, .bp-adv-sec--dark strong { color: var(--bp-lime); }\n.bp-adv strong { font-weight: 700; }\n\/* the highlight pill. Colours ride on the inline style core writes, so only\n   the shape lives here and any <mark> in the article picks it up. *\/\n.bp-adv mark {\n  padding: 0 10px; border-radius: 10px; display: inline;\n  -webkit-box-decoration-break: clone; box-decoration-break: clone;\n}\n\/* figures match the approved page exactly: card radius plus the soft shadow,\n   and a left-aligned caption rather than core's centred one *\/\n.bp-adv .wp-block-image { margin-block: var(--bp-s-5); margin-inline: auto; }\n.bp-adv .wp-block-image img { display: block; width: 100%; height: auto;\n  border-radius: var(--bp-radius-card); box-shadow: var(--bp-shadow); }\n.bp-adv .wp-block-image figcaption { font-size: var(--bp-fs-foot); line-height: 1.55;\n  color: var(--bp-foot); text-align: left; margin-block: var(--bp-s-2) 0; }\n.bp-adv .wp-block-embed, .bp-adv .wp-block-video { margin-block: var(--bp-s-5); }\n.bp-adv .wp-block-embed iframe, .bp-adv .wp-block-video video {\n  width: 100%; border-radius: var(--bp-radius-photo); }\n.bp-adv .wp-block-separator:not(.bp-adv-rule) { border: 0; border-top: 1px solid var(--bp-sand);\n  margin-block: var(--bp-s-5); }\n\n\/* quotes: core pullquote and core quote both land on the lime rule. The\n   font-size reset undoes core's own 1.5em on the figure, which would otherwise\n   leak into anything inside the quote that has no size of its own. *\/\n\/* margin-inline is load bearing, and it must be `auto` rather than `0`.\n   `blockquote` and `figure` carry a 40px side margin in the browser's own\n   default stylesheet, which indents the quote inside its rule and makes the\n   copy wrap early on a phone. But these blocks are direct children of a\n   section, so zeroing the side margin also defeats the measure rule\n   `.bp-adv-sec > * { margin-inline: auto }` and pins them to the left edge. *\/\n.bp-adv .wp-block-pullquote, .bp-adv .wp-block-quote {\n  border: 0; border-left: 5px solid var(--bp-lime); background: transparent;\n  padding: var(--bp-s-2) 0 var(--bp-s-2) var(--bp-s-5);\n  margin-block: var(--bp-s-5); margin-inline: auto;\n  text-align: left; font-size: var(--bp-fs-body);\n}\n.bp-adv .wp-block-pullquote blockquote { border: 0; margin: 0; padding: 0; }\n.bp-adv .wp-block-pullquote p, .bp-adv .wp-block-quote p {\n  font-size: 24px; line-height: 1.45; font-weight: 600;\n  margin-block: 0 var(--bp-s-2); color: var(--bp-forest); }\n.bp-adv .wp-block-pullquote cite, .bp-adv .wp-block-quote cite {\n  display: block; margin: 0; font-size: var(--bp-fs-small); color: var(--bp-foot);\n  font-style: normal; text-transform: none; }\n\n\/* buttons: two classes so core's own .wp-block-button__link cannot win *\/\n.bp-adv .wp-block-buttons { display: flex; justify-content: center;\n  margin-block: 0 var(--bp-s-4); }\n.bp-adv .wp-block-button__link {\n  display: inline-flex; align-items: center; justify-content: center; min-height: 48px;\n  background: var(--bp-teal); color: var(--bp-white); font-size: var(--bp-fs-btn);\n  font-weight: 700; line-height: 1.2; border-radius: var(--bp-radius-btn);\n  padding: 15px 44px; text-decoration: none; transition: background 250ms ease;\n  box-shadow: var(--bp-shadow);\n}\n.bp-adv .wp-block-button__link:hover { background: var(--bp-olive); color: var(--bp-white); }\n\n\/* --- slot 1: pre-headline, headline, sub-headline (Jesse's headline skill) --- *\/\n.bp-adv .bp-adv-preheadline {\n  color: var(--bp-forest); font-size: var(--bp-fs-pre); font-weight: 600; line-height: 1.5;\n  border-left: 4px solid var(--bp-lime); padding-left: var(--bp-s-3);\n  margin-block: 0 var(--bp-s-4);\n}\n.bp-adv .bp-adv-subheadline { font-size: 21px; line-height: 1.5; font-weight: 600;\n  color: var(--bp-forest); margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-standfirst { font-size: 19px; line-height: 1.65;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-lede { font-size: 18px; line-height: 1.7;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-byline { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  line-height: 1.6; margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-socialproof { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  margin-block: 0 var(--bp-s-5); }\n\/* the offer headline above the CTA. Jesse asked for a second H1 here; the brand\n   doc's accessibility rule is one h1 per page, so it is rendered at H1 size and\n   stays an h2 element. Named in the close as the one design conflict. *\/\n.bp-adv h2.bp-adv-offerhead {\n  font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); text-align: center; color: var(--bp-ink);\n  background: none; padding: 0; border: 0; border-radius: 0;\n}\n\n\/* --- Written by + Verified by. The avatar is the first child and spans the\n       three text rows, so the whole box is four ordinary paragraphs and stays\n       editable without nested columns. ---------------------------------------- *\/\n.bp-adv .bp-adv-authors {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-top: 4px solid var(--bp-lime); border-radius: var(--bp-radius-card);\n  box-shadow: var(--bp-shadow); padding: var(--bp-s-5);\n  margin-block: 0 var(--bp-s-4);\n  \/* auto-fit, so switching the verified box off leaves one full-width author\n     rather than a half-empty card *\/\n  display: grid; grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));\n  gap: var(--bp-s-5); align-items: start;\n}\n.bp-adv .bp-adv-author {\n  display: grid; grid-template-columns: 62px 1fr; gap: 0 var(--bp-s-3);\n  align-items: start; min-width: 0;\n}\n.bp-adv .bp-adv-avatar {\n  grid-row: 1 \/ span 3; width: 62px; height: 62px; border-radius: 50%;\n  background: #B7CB331F; border: 2px dashed var(--bp-olive);\n  display: flex; align-items: center; justify-content: center;\n  font-size: 10px; font-weight: 700; letter-spacing: 0.06em; color: var(--bp-forest);\n  margin-block: 0;\n}\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-avatar {\n  border-color: var(--bp-sand); background: #fff; color: var(--bp-foot); }\n.bp-adv .bp-adv-author-role {\n  font-size: 11px; font-weight: 700; letter-spacing: 0.08em; text-transform: uppercase;\n  color: var(--bp-forest); line-height: 1.6; margin-block: 0; }\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-author-role { color: var(--bp-foot); }\n.bp-adv .bp-adv-author-name { font-size: 17px; font-weight: 700; line-height: 1.35;\n  margin-block: 0; }\n.bp-adv .bp-adv-author-cred { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.55; margin-block: 0; }\n\/* the optional wrapper must not break the two-column grid of the box *\/\n.bp-adv .bp-adv-authors > .bp-optional { display: contents; }\n.bp-adv .bp-adv-authors > .bp-optional.bp-off { display: none !important; }\n\n\/* --- placeholders: image slot, video slot ---------------------------------- *\/\n.bp-adv .bp-slot {\n  display: flex; align-items: center; justify-content: center; text-align: center;\n  min-height: 180px; padding: var(--bp-s-4); margin-block: var(--bp-s-5) 0;\n  border: 2px dashed var(--bp-olive); border-radius: var(--bp-radius-photo);\n  background: #B7CB331F; color: var(--bp-forest);\n}\n.bp-adv .bp-slot p { font-size: var(--bp-fs-small); font-weight: 700; margin-block: 0; }\n.bp-adv .bp-slot--video { min-height: 260px; }\n\n\/* --- mid-article CTA band --------------------------------------------------- *\/\n.bp-adv .bp-adv-midcta {\n  background: var(--bp-grad-lime); border: 1px solid var(--bp-lime);\n  border-radius: var(--bp-radius-card); padding: var(--bp-s-5) var(--bp-s-4);\n  margin-block: var(--bp-s-6); text-align: center;\n}\n.bp-adv .bp-adv-midcta .wp-block-buttons { margin-block-end: var(--bp-s-2); }\n.bp-adv .bp-adv-midcta .bp-adv-foot { margin-block: 0; }\n\n\/* the closing CTA is one named unit in List View, so it moves and toggles as a\n   whole. It carries no box of its own: the spacing must read exactly as it does\n   on the approved page, where the three parts are plain siblings. *\/\n.bp-adv .bp-adv-ctablock { margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-ctablock .wp-block-buttons { margin-block-end: var(--bp-s-4); }\n.bp-adv .bp-adv-ctablock .bp-adv-foot { margin-block: 0; }\n\n\/* --- the condition, slot 8: the results page reference-card shape ----------- *\/\n.bp-adv .bp-adv-condition {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-left: 5px solid var(--bp-lime); border-radius: var(--bp-radius-btn);\n  padding: var(--bp-s-4) var(--bp-s-5); font-weight: 600; box-shadow: var(--bp-shadow);\n}\n\n\/* --- the numbers card: the results page focus panel, same gradient, same\n       radius, same lime figures (\"use more of that design\") ------------------ *\/\n.bp-adv .bp-adv-numcard {\n  background: linear-gradient(135deg, var(--bp-teal) 0%, var(--bp-forest) 100%);\n  border-radius: var(--bp-radius-card);\n  padding: var(--bp-s-6) var(--bp-s-5) var(--bp-s-5);\n  box-shadow: var(--bp-shadow); margin-block: var(--bp-s-5) 0;\n  position: relative; overflow: hidden;\n}\n.bp-adv .bp-adv-numcard::after {\n  content: \"\"; position: absolute; right: -70px; top: -70px; width: 240px; height: 240px;\n  border-radius: 50%; background: rgba(255,255,255,0.05); pointer-events: none;\n}\n.bp-adv .bp-adv-numcard .wp-block-columns {\n  position: relative; z-index: 1; gap: var(--bp-s-5); margin-block: 0; }\n.bp-adv .bp-adv-numcard .wp-block-column { min-width: 0; }\n.bp-adv .bp-adv-num-v { font-size: 44px; font-weight: 700; line-height: 1.12;\n  color: var(--bp-lime); text-align: center; margin-block: 0 var(--bp-s-2); }\n.bp-adv .bp-adv-num-l { font-size: var(--bp-fs-small); line-height: 1.5;\n  color: rgba(255,255,255,0.92); text-align: center; margin-block: 0; }\n.bp-adv .bp-adv-numsrc { margin-block: var(--bp-s-5) 0; }\n\n\/* --- the proof slot: a dashed card until a consented quote exists. The quote\n       inside loses its own vertical margins, otherwise the card is one full\n       block of spacing taller than the approved page. --------------------- *\/\n.bp-adv .bp-adv-testimonial {\n  border: 1px dashed var(--bp-sand); border-left: 5px dashed var(--bp-sand);\n  background: var(--bp-white); border-radius: var(--bp-radius-card);\n  padding: var(--bp-s-5); margin-block: var(--bp-s-5);\n}\n\/* the card IS the quote frame, so the quote inside it carries no rule and no\n   indent of its own; otherwise the copy is indented twice and wraps early *\/\n.bp-adv .bp-adv-testimonial .wp-block-quote {\n  border: 0; padding: 0; margin-block: 0; }\n.bp-adv .bp-adv-testimonial .wp-block-quote p {\n  font-size: 17px; font-weight: 500; color: var(--bp-foot); }\n\n\/* --- steps, footnotes, disclosure ------------------------------------------- *\/\n.bp-adv .bp-adv-steps {\n  max-width: 520px; margin-block: 0 var(--bp-s-5); margin-inline: auto;\n  padding-left: 0; list-style: none; counter-reset: bpstep; text-align: left;\n}\n.bp-adv .bp-adv-steps li { position: relative; padding-left: 40px;\n  margin-block-end: var(--bp-s-3); counter-increment: bpstep; }\n.bp-adv .bp-adv-steps li::before {\n  content: counter(bpstep); position: absolute; left: 0; top: 4px;\n  width: 26px; height: 26px; border-radius: 50%;\n  background: var(--bp-forest); color: var(--bp-white);\n  font-size: var(--bp-fs-small); font-weight: 700;\n  display: flex; align-items: center; justify-content: center; line-height: 1;\n}\n.bp-adv .bp-adv-foot { font-size: var(--bp-fs-foot); color: var(--bp-foot); line-height: 1.6; }\n.bp-adv-sec--dark .bp-adv-foot { color: rgba(255,255,255,0.82); }\n\/* Jesse's mandatory CTA subtext, 2026-07-30 15:59: directly under the button,\n   one notch above the microline in weight so it reads as part of the ask *\/\n.bp-adv .bp-adv-ctasub {\n  margin-block: calc(var(--bp-s-4) * -0.5) var(--bp-s-2); margin-inline: auto;\n  max-width: 460px; font-size: 15px; line-height: 1.5; font-weight: 600;\n  color: var(--bp-teal); text-align: center;\n}\n.bp-adv .bp-adv-disclosure { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.6; }\n.bp-adv .bp-adv-sources { margin-block-start: var(--bp-s-5); }\n.bp-adv .bp-adv-srclist { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.6; padding-left: 20px; margin-block: 0; }\n.bp-adv .bp-adv-srclist li { margin-block-end: var(--bp-s-1); }\n.bp-adv .bp-h--center { text-align: center; }\n\n@media (max-width: 767px) {\n  .bp-adv {\n    --bp-fs-h1: 30px; --bp-fs-h2: 24px; --bp-fs-h3: 20px; --bp-fs-body: 16px;\n    --bp-fs-btn: 16px; --bp-fs-pre: 14px; --bp-side: 20px;\n    --bp-s-8: 44px; --bp-s-7: 32px;\n  }\n  .bp-adv .bp-adv-subheadline { font-size: 18px; }\n  .bp-adv .bp-adv-standfirst { font-size: 17px; }\n  .bp-adv .bp-adv-lede { font-size: 16px; }\n  .bp-adv .wp-block-pullquote p, .bp-adv .wp-block-quote p { font-size: 20px; }\n  .bp-adv h2 { padding: var(--bp-s-3) var(--bp-s-4); }\n  .bp-adv .bp-adv-num-v { font-size: 36px; }\n  .bp-adv .bp-adv-authors { grid-template-columns: 1fr; gap: var(--bp-s-5); }\n  \/* the button is full width on mobile. 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Lees wat de score zegt.\",\"inLanguage\":\"nl-NL\",\"dateModified\":\"2026-10-26\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/apri\/\"},\"isPartOf\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/apri\/\"},\"publisher\":{\"@id\":\"https:\/\/bioprofile.com\/#organization\"},\"about\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/apri\/#biomarker\"},\"citation\":[{\"@type\":\"CreativeWork\",\"name\":\"Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38(2):518-26.\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12883497\/\"},{\"@type\":\"CreativeWork\",\"name\":\"BioProfile, de pakketten van het bloedonderzoek en de waarden in elk pakket.\",\"url\":\"https:\/\/bioprofile.com\/bloedonderzoek\/\"}]},{\"@type\":\"MedicalTest\",\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/apri\/#biomarker\",\"name\":\"APRI-score\",\"alternateName\":[\"APRI score\"]}]}<\/script>\n\n\n\n<section class=\"wp-block-group bp-adv bp-biomarker bp-biomarker--page is-layout-flow wp-block-group-is-layout-flow\">\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity bp-adv-rule\"\/>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--hero is-layout-flow wp-block-group-is-layout-flow\">\n\n<p class=\"bp-bm-crumbs wp-block-paragraph\"><a href=\"https:\/\/bioprofile.com\/de\/\">Home<\/a> \u203a <a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/\">Biomarker<\/a> \u203a <span>APRI-Score<\/span><\/p>\n\n\n\n<h1 class=\"wp-block-heading bp-adv-h1\">APRI-Score: Was sagt dieser Wert \u00fcber Ihre Leber aus?<\/h1>\n\n\n\n<p class=\"bp-adv-standfirst wp-block-paragraph\">In der Studie, in der der APRI-Score entwickelt wurde, sagte der Score eine erhebliche Vernarbung der Leber bei 51% der Patienten richtig voraus. Eine fortgeschrittene Vernarbung sagte der Score bei 81% richtig voraus.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"bp-adv-lede wp-block-paragraph\">Auf dieser Seite lesen Sie, was der APRI-Score ist, was die Richtlinien \u00fcber einen zu niedrigen oder zu hohen Wert sagen, was Ihren Wert beeinflusst und welche Werte Sie am besten daneben betrachten.<\/p>\n\n\n\n<p class=\"bp-bm-names wp-block-paragraph\">Auch: AST to platelet ratio index, ASAT-Blutpl\u00e4ttchen-Verh\u00e4ltnis. Im Labor: entf\u00e4llt.<\/p>\n\n\n\n<p class=\"bp-adv-byline wp-block-paragraph\">Aktualisiert am 26. Oktober 2026<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-group bp-bm-toc is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-inhoud\">Auf dieser Seite<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li><a href=\"#bp-in-het-kort\">Kurz gefasst<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-is-apri\">Was ist der APRI-Score?<\/a><\/li>\n\n\n<li><a href=\"#bp-waarom-het-ertoe-doet\">Warum der Score wichtig ist<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-je-waarde-zegt\">Was Ihr APRI-Score aussagt<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-het-beinvloedt\">Was Ihren APRI-Score beeinflusst<\/a><\/li>\n\n\n<li><a href=\"#bp-welke-pakketten\">Welche BioProfile-Pakete den APRI-Score messen<\/a><\/li>\n\n\n<li><a href=\"#bp-waarden-die-erbij-horen\">Werte, die dazugeh\u00f6ren<\/a><\/li>\n\n\n<li><a href=\"#bp-hoe-gemaakt\">Wie diese Seite entstanden ist<\/a><\/li>\n\n\n<li><a href=\"#bp-bronnen\">Quellen<\/a><\/li>\n\n<\/ul>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-in-het-kort\">Kurz gefasst<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li>Der APRI-Score ist ein einfacher Index aus zwei g\u00e4ngigen Laborwerten: ASAT und der Anzahl der Blutpl\u00e4ttchen.<sup>[1]<\/sup><\/li>\n\n\n<li>Der Score wurde entwickelt, um die Vernarbung der Leber bei Menschen mit einer lang anhaltenden Entz\u00fcndung der Leber durch ein Virus einzusch\u00e4tzen.<sup>[1]<\/sup><\/li>\n\n\n<li>Ein hoher Score kann auf eine erhebliche oder fortgeschrittene Vernarbung der Leber hinweisen.<sup>[1]<\/sup><\/li>\n\n\n<li>Nach Angaben der Forschenden kann der Score die Notwendigkeit einer Leberbiopsie verringern.<sup>[1]<\/sup><\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-is-apri\">Was ist der APRI-Score?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">APRI steht f\u00fcr AST to platelet ratio index. Es ist das Verh\u00e4ltnis zwischen ASAT (Aspartataminotransferase) und der Anzahl der Blutpl\u00e4ttchen in Ihrem Blut.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Forschende der Universit\u00e4t von Michigan beschrieben den Index im Jahr 2003. Sie suchten ein einfaches Modell mit g\u00e4ngigen Laborwerten.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Eine Vernarbung der Leber wirkt sich gegens\u00e4tzlich auf ASAT und auf die Anzahl der Blutpl\u00e4ttchen aus. Der APRI-Score wurde geschaffen, um diesen Unterschied zu verst\u00e4rken.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarom-het-ertoe-doet\">Warum der Score wichtig ist<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Bei einer lang anhaltenden Entz\u00fcndung der Leber durch ein Virus ist es wichtig zu wissen, wie weit die Vernarbung fortgeschritten ist. Diese Information ist f\u00fcr die Versorgung unverzichtbar.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Die meisten Modelle zur Einsch\u00e4tzung einer Vernarbung sind kompliziert und brauchen eigene Formeln. Der APRI-Score kommt mit einer einzigen, einfachen Berechnung aus.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Die Forschenden testeten den Score bei Patienten, bei denen eine Leberbiopsie gemacht wurde: 192 in der ersten Gruppe und 78 in der Kontrollgruppe.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In der Kontrollgruppe lag die AUC, ein Ma\u00df daf\u00fcr, wie gut der Score unterscheidet, bei 0,88 f\u00fcr eine erhebliche und bei 0,94 f\u00fcr eine fortgeschrittene Vernarbung.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-je-waarde-zegt\">Was Ihr APRI-Score aussagt<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Wai und Kollegen in Hepatology<\/h3>\n\n\n\n<figure class=\"wp-block-table bp-bm-table\"><table><thead><tr><th>Niveau<\/th><th>Kann hinweisen auf<\/th><th>F\u00fcr wen<\/th><\/tr><\/thead><tbody><tr><td>\u00dcber dem Grenzwert f\u00fcr eine erhebliche Vernarbung<sup>[1]<\/sup><\/td><td>Erhebliche Vernarbung der Leber<\/td><td>Patienten mit einer lang anhaltenden Entz\u00fcndung der Leber durch ein Virus<\/td><\/tr><tr><td>\u00dcber dem Grenzwert f\u00fcr eine fortgeschrittene Vernarbung<sup>[1]<\/sup><\/td><td>Fortgeschrittene Vernarbung der Leber<\/td><td>Patienten mit einer lang anhaltenden Entz\u00fcndung der Leber durch ein Virus<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"bp-bm-caption wp-block-paragraph\">Quelle: Wai u. a., Hepatology. Gilt f\u00fcr Patienten mit einer lang anhaltenden Entz\u00fcndung der Leber durch ein Virus. Die Zusammenfassung nennt keine Zahl f\u00fcr die Grenzwerte.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">APRI-Score zu hoch<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ein Score \u00fcber dem Grenzwert kann auf eine erhebliche oder fortgeschrittene Vernarbung der Leber hinweisen. Es bleibt eine Sch\u00e4tzung. In der Studie traf die Vorhersage bei 51% und bei 81% der Patienten zu.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BioProfile arbeitet an eigenen Zonen pro Wert, von Risiko bis optimal. Ein Arzt pr\u00fcft diese Zonen, bevor sie in Ihrem Ergebnis erscheinen.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-het-beinvloedt\">Was Ihren APRI-Score beeinflusst<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">ASAT in Ihrem Blut<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Der Score ist das Verh\u00e4ltnis zwischen ASAT und der Anzahl der Blutpl\u00e4ttchen. Ein h\u00f6herer ASAT-Wert ergibt bei gleicher Anzahl der Blutpl\u00e4ttchen einen h\u00f6heren Score.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Die Anzahl der Blutpl\u00e4ttchen<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Da die Blutpl\u00e4ttchen im Verh\u00e4ltnis unter dem Bruchstrich stehen, ergeben weniger Blutpl\u00e4ttchen bei gleichem ASAT-Wert gerade einen h\u00f6heren Score.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Vernarbung der Leber<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Nach Angaben der Forschenden wirkt sich eine Vernarbung der Leber gegens\u00e4tzlich auf ASAT und auf die Anzahl der Blutpl\u00e4ttchen aus. Der Index wurde geschaffen, um diesen Effekt zu verst\u00e4rken.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-welke-pakketten\">Welche BioProfile-Pakete den APRI-Score messen<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Der APRI-Score ist in BioProfile 77, 87, 121 und 150 enthalten.<sup>[2]<\/sup><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/bioprofile.com\/de\/blutuntersuchung\/\">Die Pakete ansehen<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarden-die-erbij-horen\">Werte, die dazugeh\u00f6ren<\/h2>\n\n\n\n<ul class=\"wp-block-list bp-bm-related\">\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/alkalische-phosphatase\/\">Alkalische Phosphatase<\/a>: In der Studie geh\u00f6rte dieser Wert zusammen mit den Blutpl\u00e4ttchen und ASAT zum besten ersten Modell, mit einer AUC von 0,82 und 0,92.<sup>[1]<\/sup><\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/alat\/\">ALAT<\/a>: ein weiterer Leberwert, den Sie neben ASAT betrachten, um ein vollst\u00e4ndigeres Bild Ihrer Leber zu bekommen.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/gesamtbilirubin\/\">Bilirubin gesamt<\/a>: zeigt, wie Ihre Leber Abfallstoffe verarbeitet, und erg\u00e4nzt den APRI-Score.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/gamma-gt\/\">Gamma-GT<\/a>: ein Leberwert, der zusammen mit ASAT und ALAT das Bild der Leber erg\u00e4nzt.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/asat\/\">ASAT<\/a>: einer der beiden Werte, aus denen der APRI-Score berechnet wird, zusammen mit der Anzahl der Blutpl\u00e4ttchen.<sup>[1]<\/sup><\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-hoe-gemaakt\">Wie diese Seite entstanden ist<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Die BioProfile-Redaktion hat diese Seite am 26. Oktober 2026 auf Grundlage der unten genannten Quellen geschrieben, die wir am 26. Oktober 2026 gelesen haben. Jede Zahl auf dieser Seite steht in einer dieser Quellen, mit der Nummer der jeweiligen Quelle dabei. Eine Fachperson pr\u00fcft diese Seite noch; nach dieser Pr\u00fcfung stehen der Name der Fachperson und das Datum der Pr\u00fcfung oben auf der Seite. Diese Seite dient der Erkl\u00e4rung und stellt keine Diagnose. Besprechen Sie einen abweichenden Wert mit Ihrem Hausarzt.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--disclosure is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-bronnen\">Quellen<\/h2>\n\n\n\n<ol class=\"wp-block-list bp-adv-srclist bp-bm-src\">\n\n<li>Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38(2):518-26. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12883497\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/12883497\/<\/a><\/li>\n\n\n<li>BioProfile, die Pakete der Blutuntersuchung und die Werte in jedem Paket. <a href=\"https:\/\/bioprofile.com\/de\/blutuntersuchung\/\" target=\"_blank\" rel=\"noopener\">https:\/\/bioprofile.com\/de\/blutuntersuchung\/<\/a><\/li>\n\n<\/ol>\n\n<\/div>\n\n<\/section>\n\n","protected":false},"excerpt":{"rendered":"<p>Home \u203a Biomarker \u203a APRI-Score APRI-Score: Was sagt dieser Wert \u00fcber Ihre Leber aus? In der Studie, in der der APRI-Score entwickelt wurde, sagte der Score eine erhebliche Vernarbung der Leber bei 51% der Patienten richtig voraus. Eine fortgeschrittene Vernarbung sagte der Score bei 81% richtig voraus.[1] Auf dieser Seite lesen Sie, was der APRI-Score [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":0,"parent":6596,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_yoast_wpseo_title":"APRI-Score: Bedeutung und Erkl\u00e4rung | BioProfile","_yoast_wpseo_metadesc":"Der APRI-Score verbindet ASAT und Blutpl\u00e4ttchen zu einem Wert, der auf eine Vernarbung der Leber hinweisen kann. 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