{"id":13854,"date":"2026-10-29T11:00:00","date_gmt":"2026-10-29T11:00:00","guid":{"rendered":"https:\/\/bioprofile.com\/?page_id=13854"},"modified":"2026-11-05T22:38:08","modified_gmt":"2026-11-05T22:38:08","slug":"hsi","status":"publish","type":"page","link":"https:\/\/bioprofile.com\/de\/biomarkers\/hsi\/","title":{"rendered":"HSI-Index (Leber)"},"content":{"rendered":"\n<div id=\"content\" tabindex=\"-1\"><\/div>\n<style>@import url('https:\/\/fonts.googleapis.com\/css2?family=Poppins:ital,wght@0,400;0,600;0,700;0,800;1,400&display=swap');\n\/* ===========================================================================\n   BioProfile advertorial, the design Jesse approved on 2026-07-30, expressed\n   as a WordPress design system.\n\n   THE @import IS LOAD BEARING and must stay the first thing in this sheet (a\n   CSS @import after any rule is dropped by the parser). elementor_canvas does\n   not enqueue the theme's fonts, so without it the whole page falls back to the\n   system font. Caught by LOOKING at the live page on 2026-07-30, right after\n   the template was switched to canvas.\n\n   Everything is scoped to `.bp-adv`, so nothing here can reach the rest of\n   bioprofile.com, and core blocks are styled BY ELEMENT so a heading, a\n   paragraph, a quote, a list, an image or a button inserted by hand inside the\n   advertorial comes out on-design with no class to remember.\n\n   Jesse's design feedback, 2026-07-29 23:38, point by point:\n   1. the light green and the dark green are the preferred colours; grey may be\n      used but the page must NOT open grey;\n   2. more colour and variation across sections, e.g. a colour block on the left\n      or the right side of a section, without overdesign;\n   3. ONE H1, plain text on white; everything else H2 or H3; an H2 may carry its\n      own background colour so the page can be read from the headings alone; an\n      H3 keeps its section background and gets a bigger font size;\n   4. reuse the results page design feel;\n   5. Written by \/ Verified by, the placeholder blocks and noindex stay.\n\n   COLOUR PROVENANCE. Not one hex is invented.\n   - #b7cb32  LIGHT GREEN, brand manual \"colours rejuvenation protocol\"\n              (R183 G203 B51). Same value as --bp-lime in\n              brands\/bioprofile\/brand\/tokens.md.\n   - #006b62  DARK GREEN, brand manual, nourish the cells (R0 G107 B98).\n   - #005859  brand manual primary teal, the value the brand is built on.\n   - #228a62  brand manual, challenge the body (R34 G138 B98).\n   - #7ca64c  brand manual, calm the mind (R124 G166 B76).\n   - #dbd4cd  brand manual \"additional color\", the warm neutral.\n   - #B7CB3329 is the brand token --bp-lime-soft (light green at 16 percent).\n   - the gradients are the brand token layer's own, copied verbatim.\n\n   SPECIFICITY NOTE. Elementor's global kit emits `.elementor-kit-6 h2` style\n   rules at (0,1,1). Element rules below are written `.bp-adv h2`, also (0,1,1),\n   and win on source order because this sheet is inline in the body while the\n   kit is a <link> in the head. Component rules that MUST NOT lose carry two\n   classes, e.g. `.bp-adv .wp-block-button__link`.\n\n   LAYOUT NOTE. Vertical rhythm uses `margin-block` and never the `margin`\n   shorthand, so the measure rule `.bp-adv-sec > * { margin-inline: auto }` can\n   centre a block without being outranked by its own element rule.\n   =========================================================================== *\/\n\n.bp-adv {\n  --bp-ink: #212527;\n  --bp-teal: #005859;\n  --bp-forest: #006B62;\n  --bp-emerald: #228A62;\n  --bp-olive: #7CA64C;\n  --bp-lime: #B7CB33;\n  --bp-lime-soft: #B7CB3329;\n  --bp-sand: #DBD4CB;\n  --bp-white: #FFFFFF;\n  --bp-foot: #6b6b6b;\n  --bp-grad-dark: linear-gradient(237deg, rgba(0,88,89,0.00) 62.94%, #005859 100%), linear-gradient(90deg, rgba(34,138,98,0.00) 40%, #228A62 100%), #006B62;\n  --bp-grad-lime: linear-gradient(110deg, rgba(183,203,51,0.00) 36.06%, rgba(183,203,51,0.25) 97.65%), #FFFFFF;\n  --bp-font: 'Poppins','Segoe UI',Arial,sans-serif;\n  --bp-fs-h1: 44px; --bp-fs-h2: 31px; --bp-fs-h3: 24px; --bp-fs-pre: 15px;\n  --bp-fs-body: 17px; --bp-fs-small: 14px; --bp-fs-foot: 13px; --bp-fs-btn: 17px;\n  --bp-lh-body: 1.75;\n  --bp-s-1: 4px; --bp-s-2: 8px; --bp-s-3: 12px; --bp-s-4: 16px;\n  --bp-s-5: 24px; --bp-s-6: 32px; --bp-s-7: 44px; --bp-s-8: 72px;\n  --bp-measure: 760px; --bp-side: 40px;\n  --bp-radius-photo: 16px; --bp-radius-btn: 10px; --bp-radius-card: 20px;\n  --bp-shadow: 0 10px 30px rgba(0,88,89,0.10);\n  font-family: var(--bp-font);\n  font-size: var(--bp-fs-body);\n  line-height: var(--bp-lh-body);\n  color: var(--bp-ink);\n  background: var(--bp-white);\n  -webkit-font-smoothing: antialiased;\n}\n.bp-adv, .bp-adv * { box-sizing: border-box; }\n.bp-adv p, .bp-adv li, .bp-adv h1, .bp-adv h2, .bp-adv h3, .bp-adv blockquote,\n.bp-adv a, .bp-adv cite, .bp-adv span { overflow-wrap: break-word; min-width: 0; }\n\n\/* THE TOGGLE. One word in the block's own \"Additional CSS class(es)\" field\n   hides an optional component on the front end without deleting anything. *\/\n.bp-adv .bp-off { display: none !important; }\n\n\/* the page opens on green, never on grey (his point 1) *\/\n.bp-adv .bp-adv-rule {\n  height: 6px; border: 0; margin-block: 0; max-width: none;\n  background: linear-gradient(90deg, #005859 0%, #006B62 38%, #228A62 66%, #B7CB33 100%);\n}\n\n\/* --- section surfaces ------------------------------------------------------ *\/\n.bp-adv-sec { position: relative; background: var(--bp-white);\n  padding: var(--bp-s-8) var(--bp-side); margin-block: 0; }\n\/* the measure: every direct child of a section is the 760px text column *\/\n.bp-adv-sec > * { max-width: var(--bp-measure); margin-inline: auto; }\n.bp-adv-sec > *:last-child { margin-block-end: 0; }\n.bp-adv-sec--wash  { background: linear-gradient(180deg, #B7CB331F 0%, #B7CB3312 100%), #FFFFFF; }\n.bp-adv-sec--dark  { background: var(--bp-grad-dark); color: var(--bp-white); }\n.bp-adv-sec--dark p, .bp-adv-sec--dark cite, .bp-adv-sec--dark li { color: var(--bp-white); }\n.bp-adv-sec--offer { background: var(--bp-grad-lime); text-align: center; }\n.bp-adv-sec--hero  { padding-block-start: var(--bp-s-6); }\n.bp-adv-sec--disclosure { padding-block: var(--bp-s-6);\n  border-top: 1px solid var(--bp-sand); }\n\n\/* --- the side accent bar, his own example (\"a colour block on the left or the\n       right side of a section\"), design rev 3: a slim vertical bar hugging the\n       text column rather than a wide margin panel. Below 1100px the margin is\n       gone, so it becomes a slim top edge. ---------------------------------- *\/\n.bp-adv-rail { overflow: hidden; }\n.bp-adv-rail::before {\n  content: \"\"; position: absolute; top: var(--bp-s-7); bottom: var(--bp-s-7);\n  width: 6px; border-radius: 3px;\n  background: linear-gradient(180deg, var(--bp-forest) 0%, var(--bp-lime) 100%);\n}\n.bp-adv-rail--left::before  { left: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n.bp-adv-rail--right::before { right: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n@media (max-width: 1099px) {\n  .bp-adv-rail::before { left: 0; right: 0; width: auto; bottom: auto; top: 0;\n    height: 4px; border-radius: 0; background: var(--bp-lime); }\n}\n\n\/* --- CORE BLOCKS, styled by element. This is the part that makes an inserted\n       block come out on-design with no class. --------------------------------- *\/\n.bp-adv p { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv h1 { font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); }\n\/* an H2 is its own colour band, so the page can be read from the headings\n   alone (his point 3). Dark green on light sections, light green on the dark\n   one, so a heading always wins against its own background. *\/\n.bp-adv h2 {\n  font-size: var(--bp-fs-h2); font-weight: 700; line-height: 1.28;\n  margin-block: 0 var(--bp-s-5);\n  background: var(--bp-grad-dark); color: var(--bp-white);\n  padding: var(--bp-s-4) var(--bp-s-5);\n  border-radius: var(--bp-radius-btn);\n  border-left: 6px solid var(--bp-lime);\n}\n.bp-adv-sec--dark h2 { background: var(--bp-lime); color: var(--bp-ink);\n  border-left-color: var(--bp-forest); }\n\/* H3: same background as its section, bigger font (his point 3, verbatim) *\/\n.bp-adv h3 { font-size: var(--bp-fs-h3); font-weight: 700; line-height: 1.35;\n  color: var(--bp-forest); background: transparent; margin-block: 0 var(--bp-s-3); }\n.bp-adv-sec--dark h3 { color: var(--bp-lime); }\n.bp-adv ul, .bp-adv ol { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); padding-left: var(--bp-s-5); }\n.bp-adv li { margin-block-end: var(--bp-s-2); }\n.bp-adv a { color: var(--bp-teal); text-decoration: underline; }\n.bp-adv a:hover { color: var(--bp-olive); }\n.bp-adv-sec--dark a, .bp-adv-sec--dark strong { color: var(--bp-lime); }\n.bp-adv strong { font-weight: 700; }\n\/* the highlight pill. Colours ride on the inline style core writes, so only\n   the shape lives here and any <mark> in the article picks it up. *\/\n.bp-adv mark {\n  padding: 0 10px; border-radius: 10px; display: inline;\n  -webkit-box-decoration-break: clone; box-decoration-break: clone;\n}\n\/* figures match the approved page exactly: card radius plus the soft shadow,\n   and a left-aligned caption rather than core's centred one *\/\n.bp-adv .wp-block-image { margin-block: var(--bp-s-5); margin-inline: auto; }\n.bp-adv .wp-block-image img { display: block; width: 100%; height: auto;\n  border-radius: var(--bp-radius-card); box-shadow: var(--bp-shadow); }\n.bp-adv .wp-block-image figcaption { font-size: var(--bp-fs-foot); line-height: 1.55;\n  color: var(--bp-foot); text-align: left; margin-block: var(--bp-s-2) 0; }\n.bp-adv .wp-block-embed, .bp-adv .wp-block-video { margin-block: var(--bp-s-5); }\n.bp-adv .wp-block-embed iframe, .bp-adv .wp-block-video video {\n  width: 100%; border-radius: var(--bp-radius-photo); }\n.bp-adv .wp-block-separator:not(.bp-adv-rule) { border: 0; border-top: 1px solid var(--bp-sand);\n  margin-block: var(--bp-s-5); }\n\n\/* quotes: core pullquote and core quote both land on the lime rule. The\n   font-size reset undoes core's own 1.5em on the figure, which would otherwise\n   leak into anything inside the quote that has no size of its own. *\/\n\/* margin-inline is load bearing, and it must be `auto` rather than `0`.\n   `blockquote` and `figure` carry a 40px side margin in the browser's own\n   default stylesheet, which indents the quote inside its rule and makes the\n   copy wrap early on a phone. But these blocks are direct children of a\n   section, so zeroing the side margin also defeats the measure rule\n   `.bp-adv-sec > * { margin-inline: auto }` and pins them to the left edge. *\/\n.bp-adv .wp-block-pullquote, .bp-adv .wp-block-quote {\n  border: 0; border-left: 5px solid var(--bp-lime); background: transparent;\n  padding: var(--bp-s-2) 0 var(--bp-s-2) var(--bp-s-5);\n  margin-block: var(--bp-s-5); margin-inline: auto;\n  text-align: left; font-size: var(--bp-fs-body);\n}\n.bp-adv .wp-block-pullquote blockquote { border: 0; margin: 0; padding: 0; }\n.bp-adv .wp-block-pullquote p, .bp-adv .wp-block-quote p {\n  font-size: 24px; line-height: 1.45; font-weight: 600;\n  margin-block: 0 var(--bp-s-2); color: var(--bp-forest); }\n.bp-adv .wp-block-pullquote cite, .bp-adv .wp-block-quote cite {\n  display: block; margin: 0; font-size: var(--bp-fs-small); color: var(--bp-foot);\n  font-style: normal; text-transform: none; }\n\n\/* buttons: two classes so core's own .wp-block-button__link cannot win *\/\n.bp-adv .wp-block-buttons { display: flex; justify-content: center;\n  margin-block: 0 var(--bp-s-4); }\n.bp-adv .wp-block-button__link {\n  display: inline-flex; align-items: center; justify-content: center; min-height: 48px;\n  background: var(--bp-teal); color: var(--bp-white); font-size: var(--bp-fs-btn);\n  font-weight: 700; line-height: 1.2; border-radius: var(--bp-radius-btn);\n  padding: 15px 44px; text-decoration: none; transition: background 250ms ease;\n  box-shadow: var(--bp-shadow);\n}\n.bp-adv .wp-block-button__link:hover { background: var(--bp-olive); color: var(--bp-white); }\n\n\/* --- slot 1: pre-headline, headline, sub-headline (Jesse's headline skill) --- *\/\n.bp-adv .bp-adv-preheadline {\n  color: var(--bp-forest); font-size: var(--bp-fs-pre); font-weight: 600; line-height: 1.5;\n  border-left: 4px solid var(--bp-lime); padding-left: var(--bp-s-3);\n  margin-block: 0 var(--bp-s-4);\n}\n.bp-adv .bp-adv-subheadline { font-size: 21px; line-height: 1.5; font-weight: 600;\n  color: var(--bp-forest); margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-standfirst { font-size: 19px; line-height: 1.65;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-lede { font-size: 18px; line-height: 1.7;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-byline { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  line-height: 1.6; margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-socialproof { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  margin-block: 0 var(--bp-s-5); }\n\/* the offer headline above the CTA. Jesse asked for a second H1 here; the brand\n   doc's accessibility rule is one h1 per page, so it is rendered at H1 size and\n   stays an h2 element. Named in the close as the one design conflict. *\/\n.bp-adv h2.bp-adv-offerhead {\n  font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); text-align: center; color: var(--bp-ink);\n  background: none; padding: 0; border: 0; border-radius: 0;\n}\n\n\/* --- Written by + Verified by. The avatar is the first child and spans the\n       three text rows, so the whole box is four ordinary paragraphs and stays\n       editable without nested columns. ---------------------------------------- *\/\n.bp-adv .bp-adv-authors {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-top: 4px solid var(--bp-lime); border-radius: var(--bp-radius-card);\n  box-shadow: var(--bp-shadow); padding: var(--bp-s-5);\n  margin-block: 0 var(--bp-s-4);\n  \/* auto-fit, so switching the verified box off leaves one full-width author\n     rather than a half-empty card *\/\n  display: grid; grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));\n  gap: var(--bp-s-5); align-items: start;\n}\n.bp-adv .bp-adv-author {\n  display: grid; grid-template-columns: 62px 1fr; gap: 0 var(--bp-s-3);\n  align-items: start; min-width: 0;\n}\n.bp-adv .bp-adv-avatar {\n  grid-row: 1 \/ span 3; width: 62px; height: 62px; border-radius: 50%;\n  background: #B7CB331F; border: 2px dashed var(--bp-olive);\n  display: flex; align-items: center; justify-content: center;\n  font-size: 10px; font-weight: 700; letter-spacing: 0.06em; color: var(--bp-forest);\n  margin-block: 0;\n}\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-avatar {\n  border-color: var(--bp-sand); background: #fff; color: var(--bp-foot); }\n.bp-adv .bp-adv-author-role {\n  font-size: 11px; font-weight: 700; letter-spacing: 0.08em; text-transform: uppercase;\n  color: var(--bp-forest); line-height: 1.6; margin-block: 0; }\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-author-role { color: var(--bp-foot); }\n.bp-adv .bp-adv-author-name { font-size: 17px; font-weight: 700; line-height: 1.35;\n  margin-block: 0; }\n.bp-adv .bp-adv-author-cred { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.55; margin-block: 0; }\n\/* the optional wrapper must not break the two-column grid of the box *\/\n.bp-adv .bp-adv-authors > .bp-optional { display: contents; }\n.bp-adv .bp-adv-authors > .bp-optional.bp-off { display: none !important; }\n\n\/* --- placeholders: image slot, video slot ---------------------------------- *\/\n.bp-adv .bp-slot {\n  display: flex; align-items: center; justify-content: center; text-align: center;\n  min-height: 180px; padding: var(--bp-s-4); margin-block: var(--bp-s-5) 0;\n  border: 2px dashed var(--bp-olive); border-radius: var(--bp-radius-photo);\n  background: #B7CB331F; color: var(--bp-forest);\n}\n.bp-adv .bp-slot p { font-size: var(--bp-fs-small); font-weight: 700; margin-block: 0; }\n.bp-adv .bp-slot--video { min-height: 260px; }\n\n\/* --- mid-article CTA band --------------------------------------------------- *\/\n.bp-adv .bp-adv-midcta {\n  background: var(--bp-grad-lime); border: 1px solid var(--bp-lime);\n  border-radius: var(--bp-radius-card); padding: var(--bp-s-5) var(--bp-s-4);\n  margin-block: var(--bp-s-6); text-align: center;\n}\n.bp-adv .bp-adv-midcta .wp-block-buttons { margin-block-end: var(--bp-s-2); }\n.bp-adv .bp-adv-midcta .bp-adv-foot { margin-block: 0; }\n\n\/* the closing CTA is one named unit in List View, so it moves and toggles as a\n   whole. It carries no box of its own: the spacing must read exactly as it does\n   on the approved page, where the three parts are plain siblings. *\/\n.bp-adv .bp-adv-ctablock { margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-ctablock .wp-block-buttons { margin-block-end: var(--bp-s-4); }\n.bp-adv .bp-adv-ctablock .bp-adv-foot { margin-block: 0; }\n\n\/* --- the condition, slot 8: the results page reference-card shape ----------- *\/\n.bp-adv .bp-adv-condition {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-left: 5px solid var(--bp-lime); border-radius: var(--bp-radius-btn);\n  padding: var(--bp-s-4) var(--bp-s-5); font-weight: 600; box-shadow: var(--bp-shadow);\n}\n\n\/* --- the numbers card: the results page focus panel, same gradient, same\n       radius, same lime figures (\"use more of that design\") ------------------ *\/\n.bp-adv .bp-adv-numcard {\n  background: linear-gradient(135deg, var(--bp-teal) 0%, var(--bp-forest) 100%);\n  border-radius: var(--bp-radius-card);\n  padding: var(--bp-s-6) var(--bp-s-5) var(--bp-s-5);\n  box-shadow: var(--bp-shadow); margin-block: var(--bp-s-5) 0;\n  position: relative; overflow: hidden;\n}\n.bp-adv .bp-adv-numcard::after {\n  content: \"\"; position: absolute; right: -70px; top: -70px; width: 240px; height: 240px;\n  border-radius: 50%; background: rgba(255,255,255,0.05); pointer-events: none;\n}\n.bp-adv .bp-adv-numcard .wp-block-columns {\n  position: relative; z-index: 1; gap: var(--bp-s-5); margin-block: 0; }\n.bp-adv .bp-adv-numcard .wp-block-column { min-width: 0; }\n.bp-adv .bp-adv-num-v { font-size: 44px; font-weight: 700; line-height: 1.12;\n  color: var(--bp-lime); text-align: center; margin-block: 0 var(--bp-s-2); }\n.bp-adv .bp-adv-num-l { font-size: var(--bp-fs-small); line-height: 1.5;\n  color: rgba(255,255,255,0.92); text-align: center; margin-block: 0; }\n.bp-adv .bp-adv-numsrc { margin-block: var(--bp-s-5) 0; }\n\n\/* --- the proof slot: a dashed card until a consented quote exists. 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Helder uitgelegd.\",\"inLanguage\":\"nl-NL\",\"dateModified\":\"2026-10-27\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/hsi\/\"},\"isPartOf\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/hsi\/\"},\"publisher\":{\"@id\":\"https:\/\/bioprofile.com\/#organization\"},\"about\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/hsi\/#biomarker\"},\"citation\":[{\"@type\":\"CreativeWork\",\"name\":\"Lee JH, Kim D, Kim HJ, et al. Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease. Dig Liver Dis. 2010;42(7):503-8.\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19766548\/\"},{\"@type\":\"CreativeWork\",\"name\":\"BioProfile, de pakketten van het bloedonderzoek en de waarden in elk pakket.\",\"url\":\"https:\/\/bioprofile.com\/bloedonderzoek\/\"}]},{\"@type\":\"MedicalTest\",\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/hsi\/#biomarker\",\"name\":\"HSI-index (lever)\",\"alternateName\":[\"Hepatic steatosis index\"]}]}<\/script>\n\n\n\n<section class=\"wp-block-group bp-adv bp-biomarker bp-biomarker--page is-layout-flow wp-block-group-is-layout-flow\">\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity bp-adv-rule\"\/>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--hero is-layout-flow wp-block-group-is-layout-flow\">\n\n<p class=\"bp-bm-crumbs wp-block-paragraph\"><a href=\"https:\/\/bioprofile.com\/de\/\">Home<\/a> \u203a <a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/\">Biomarker<\/a> \u203a <span>HSI-Index (Leber)<\/span><\/p>\n\n\n\n<h1 class=\"wp-block-heading bp-adv-h1\">HSI-Index (Leber)<\/h1>\n\n\n\n<p class=\"bp-adv-standfirst wp-block-paragraph\">In einer Studie mit Teilnehmenden eines Check-ups schloss ein HSI unter 30,0 eine Leberverfettung, die nicht durch Alkohol entsteht, mit einer Sensitivit\u00e4t von 93,1% aus. Ein HSI \u00fcber 36,0 kann dagegen auf diese Verfettung hindeuten.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"bp-adv-lede wp-block-paragraph\">Auf dieser Seite lesen Sie, was der HSI-Index (Leber) ist, was die Richtlinien \u00fcber einen zu niedrigen oder zu hohen Wert sagen, was Ihren Wert beeinflusst und welche Werte Sie am besten zus\u00e4tzlich betrachten.<\/p>\n\n\n\n<p class=\"bp-bm-names wp-block-paragraph\">Auch: hepatic steatosis index, HSI. Im Labor: nicht zutreffend.<\/p>\n\n\n\n<p class=\"bp-adv-byline wp-block-paragraph\">Aktualisiert am 27. Oktober 2026<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-group bp-bm-toc is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-inhoud\">Auf dieser Seite<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li><a href=\"#bp-in-het-kort\">Kurz gefasst<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-is-hsi\">Was ist der HSI-Index (Leber)?<\/a><\/li>\n\n\n<li><a href=\"#bp-waarom-het-ertoe-doet\">Warum der HSI wichtig ist<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-je-waarde-zegt\">Was Ihr HSI-Wert aussagt<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-het-beinvloedt\">Was Ihren HSI-Index (Leber) beeinflusst<\/a><\/li>\n\n\n<li><a href=\"#bp-welke-pakketten\">Welche BioProfile-Pakete den HSI-Index (Leber) messen<\/a><\/li>\n\n\n<li><a href=\"#bp-waarden-die-erbij-horen\">Werte, die dazugeh\u00f6ren<\/a><\/li>\n\n\n<li><a href=\"#bp-hoe-gemaakt\">Wie diese Seite entstanden ist<\/a><\/li>\n\n\n<li><a href=\"#bp-bronnen\">Quellen<\/a><\/li>\n\n<\/ul>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-in-het-kort\">Kurz gefasst<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li>Der HSI ist ein Wert aus dem Verh\u00e4ltnis von ALAT zu ASAT und Ihrem BMI, mit zus\u00e4tzlichen Punkten f\u00fcr Frauen und bei einer Erkrankung der Blutzuckerregulation.<sup>[1]<\/sup><\/li>\n\n\n<li>Unter 30,0 schloss der Wert eine Leberverfettung, die nicht durch Alkohol entsteht, mit einer Sensitivit\u00e4t von 93,1% aus.<sup>[1]<\/sup><\/li>\n\n\n<li>\u00dcber 36,0 wies der Wert auf diese Verfettung hin, mit einer Spezifit\u00e4t von 92,4%.<sup>[1]<\/sup><\/li>\n\n\n<li>Die Forschenden sehen den HSI als einfaches Ma\u00df f\u00fcr ein Screening, unter anderem um zu entscheiden, wer einen Ultraschall der Leber erh\u00e4lt.<sup>[1]<\/sup><\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-is-hsi\">Was ist der HSI-Index (Leber)?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Der HSI ist ein berechneter Wert, keine eigene Messung in Ihrem Blut. Er stammt aus einer Studie, die nach einem einfachen Ma\u00df f\u00fcr eine Leberverfettung suchte, die nicht durch Alkohol entsteht.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Die Formel lautet: 8 mal das Verh\u00e4ltnis von ALAT zu ASAT, plus Ihr BMI. Sind Sie eine Frau, kommen 2 hinzu. Haben Sie eine Erkrankung der Blutzuckerregulation, kommen ebenfalls 2 hinzu.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In der Studie hatte der HSI eine Fl\u00e4che unter der ROC-Kurve von 0,812. Das ist ein Ma\u00df daf\u00fcr, wie gut der Wert Teilnehmende mit und ohne Leberverfettung voneinander unterscheidet.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarom-het-ertoe-doet\">Warum der HSI wichtig ist<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Die Forschenden wollten ein einfaches Ma\u00df, um eine Leberverfettung zu erkennen, die nicht durch Alkohol entsteht. Der HSI nutzt daf\u00fcr wenige Angaben: zwei Leberwerte, Ihren BMI, Ihr Geschlecht und ob Sie eine Erkrankung der Blutzuckerregulation haben.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Von den 2692 Teilnehmenden mit einem HSI unter 30,0 oder \u00fcber 36,0 wurden 2305 richtig eingeordnet. Das sind 85,6%.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Laut den Forschenden kann der HSI dabei helfen, zu entscheiden, wer eine Ultraschalluntersuchung der Leber bekommt, und festzustellen, ob \u00c4nderungen im Lebensstil n\u00f6tig sind.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-je-waarde-zegt\">Was Ihr HSI-Wert aussagt<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Was die Studie von Lee und Kollegen sagt<\/h3>\n\n\n\n<figure class=\"wp-block-table bp-bm-table\"><table><thead><tr><th>Wert<\/th><th>Kann hinweisen auf<\/th><th>F\u00fcr wen<\/th><\/tr><\/thead><tbody><tr><td>Unter 30,0<sup>[1]<\/sup><\/td><td>Schlie\u00dft eine Leberverfettung, die nicht durch Alkohol entsteht, mit einer Sensitivit\u00e4t von 93,1% aus<\/td><td>Teilnehmende eines Check-ups in der Studie<\/td><\/tr><tr><td>Zwischen 30,0 und 36,0<sup>[1]<\/sup><\/td><td>Die Studie nutzt diese Werte nicht, um eine Verfettung auszuschlie\u00dfen oder nachzuweisen<\/td><td>Teilnehmende eines Check-ups in der Studie<\/td><\/tr><tr><td>\u00dcber 36,0<sup>[1]<\/sup><\/td><td>Kann auf eine Leberverfettung hindeuten, die nicht durch Alkohol entsteht, mit einer Spezifit\u00e4t von 92,4%<\/td><td>Teilnehmende eines Check-ups in der Studie<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"bp-bm-caption wp-block-paragraph\">Quelle: Lee u. a., Dig Liver Dis 2010. Grenzwerte aus einer Studie mit Teilnehmenden eines Check-ups.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HSI-Index (Leber) zu hoch<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u00dcber 36,0 wies der HSI in der Studie auf eine Leberverfettung hin, die nicht durch Alkohol entsteht, mit einer Spezifit\u00e4t von 92,4%. Ein hoher Wert kann also auf Fett in der Leber hindeuten. Laut den Forschenden kann das ein Grund f\u00fcr einen Ultraschall der Leber oder f\u00fcr Anpassungen des Lebensstils sein.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HSI-Index (Leber) zu niedrig<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Unter 30,0 schloss der HSI in der Studie eine Leberverfettung, die nicht durch Alkohol entsteht, mit einer Sensitivit\u00e4t von 93,1% aus. Ein niedriger Wert kann also darauf hindeuten, dass keine solche Verfettung vorliegt.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BioProfile arbeitet an eigenen Zonen pro Wert, von Risiko bis optimal. Ein Arzt pr\u00fcft diese Zonen, bevor sie in Ihrem Ergebnis erscheinen.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-het-beinvloedt\">Was Ihren HSI-Index (Leber) beeinflusst<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Ihre Leberwerte ALAT und ASAT<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ein hohes Verh\u00e4ltnis von ALAT zu ASAT war in der Studie ein Risikofaktor f\u00fcr eine Leberverfettung. In der Formel z\u00e4hlt dieses Verh\u00e4ltnis 8-fach.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Ihr BMI<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ein hoher BMI war in der Studie ebenfalls ein Risikofaktor. Ihr BMI wird direkt zum Wert addiert, ein h\u00f6herer BMI ergibt also einen h\u00f6heren HSI.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Ihr Geschlecht<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Sind Sie eine Frau, rechnet die Formel 2 hinzu.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Ihre Blutzuckerregulation<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Eine Erkrankung der Blutzuckerregulation war in der Studie ein Risikofaktor. Haben Sie eine solche Erkrankung, rechnet die Formel 2 hinzu.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-welke-pakketten\">Welche BioProfile-Pakete den HSI-Index (Leber) messen<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Der HSI-Index (Leber) ist in BioProfile 77, 87, 121 und 150 enthalten.<sup>[2]<\/sup><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/bioprofile.com\/de\/blutuntersuchung\/\">Die Pakete ansehen<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarden-die-erbij-horen\">Werte, die dazugeh\u00f6ren<\/h2>\n\n\n\n<ul class=\"wp-block-list bp-bm-related\">\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/alkalische-phosphatase\/\">Alkalische Phosphatase<\/a>: ein weiterer Leberwert, der zusammen mit dem HSI ein breiteres Bild Ihrer Leber gibt.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/alat\/\">ALAT<\/a>: einer der beiden Leberwerte in der Formel des HSI. Ein hohes Verh\u00e4ltnis von ALAT zu ASAT war in der Studie ein Risikofaktor.<sup>[1]<\/sup><\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/gesamtbilirubin\/\">Bilirubin gesamt<\/a>: ein Abbauprodukt, das Ihre Leber verarbeitet. Zusammen mit dem HSI betrachtet, gibt es ein breiteres Bild Ihrer Leber.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/gamma-gt\/\">Gamma-GT<\/a>: ein Leberenzym, das zus\u00e4tzlich zum HSI einen anderen Teil des Bildes Ihrer Leber zeigt.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/de\/biomarkers\/asat\/\">ASAT<\/a>: der zweite Leberwert in der Formel des HSI. Zusammen mit ALAT bildet er das Verh\u00e4ltnis, das in den Wert einflie\u00dft.<sup>[1]<\/sup><\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-hoe-gemaakt\">Wie diese Seite entstanden ist<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Die BioProfile-Redaktion hat diese Seite am 27. Oktober 2026 auf Grundlage der unten genannten Quellen geschrieben, die wir am 27. Oktober 2026 gelesen haben. Jede Zahl auf dieser Seite steht in einer dieser Quellen, mit der Nummer der jeweiligen Quelle dabei. Eine Fachperson pr\u00fcft diese Seite noch; nach dieser Pr\u00fcfung stehen der Name der Fachperson und das Datum der Pr\u00fcfung oben. Diese Seite dient der Erkl\u00e4rung und stellt keine Diagnose dar. Besprechen Sie einen auff\u00e4lligen Wert mit Ihrem Hausarzt.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--disclosure is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-bronnen\">Quellen<\/h2>\n\n\n\n<ol class=\"wp-block-list bp-adv-srclist bp-bm-src\">\n\n<li>Lee JH, Kim D, Kim HJ, et al. Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease. Dig Liver Dis. 2010;42(7):503-8. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19766548\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/19766548\/<\/a><\/li>\n\n\n<li>BioProfile, die Pakete der Blutuntersuchung und die Werte in jedem Paket. <a href=\"https:\/\/bioprofile.com\/de\/blutuntersuchung\/\" target=\"_blank\" rel=\"noopener\">https:\/\/bioprofile.com\/de\/blutuntersuchung\/<\/a><\/li>\n\n<\/ol>\n\n<\/div>\n\n<\/section>\n\n","protected":false},"excerpt":{"rendered":"<p>Home \u203a Biomarker \u203a HSI-Index (Leber) HSI-Index (Leber) In einer Studie mit Teilnehmenden eines Check-ups schloss ein HSI unter 30,0 eine Leberverfettung, die nicht durch Alkohol entsteht, mit einer Sensitivit\u00e4t von 93,1% aus. Ein HSI \u00fcber 36,0 kann dagegen auf diese Verfettung hindeuten.[1] Auf dieser Seite lesen Sie, was der HSI-Index (Leber) ist, was die [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":0,"parent":6596,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_yoast_wpseo_title":"HSI-Index (Leber): was Ihr Wert aussagt | BioProfile","_yoast_wpseo_metadesc":"Was ist der HSI-Index (Leber), wie wird der Wert berechnet und was kann ein niedriger oder hoher Wert \u00fcber Fett in Ihrer Leber aussagen? 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