{"id":7108,"date":"2026-08-19T08:24:34","date_gmt":"2026-08-19T08:24:34","guid":{"rendered":"https:\/\/bioprofile.com\/?page_id=7108"},"modified":"2026-09-30T12:19:36","modified_gmt":"2026-09-30T12:19:36","slug":"advertorial-not-worn-out-your-cells-doing-other-work","status":"publish","type":"page","link":"https:\/\/bioprofile.com\/en\/advertorial-not-worn-out-your-cells-doing-other-work\/","title":{"rendered":"Not Worn Out: The Cells That Maintain Your Joints Have Started Doing Other Work"},"content":{"rendered":"\n<div class=\"wp-block-group bp-adv is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-group bp-adv-stickycta is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"bp-adv-stickycta-row\"><a class=\"bp-adv-sitehead-cta\" id=\"bp-adv-sitehead-cta\" href=\"https:\/\/app.bioprofile.com\/mini?src=site-header&amp;lang=en\">Start your analysis<\/a><\/div>\n<script id=\"bp-adv-sitehead-js\">\n(function () {\n  var TEXT = {\"analyse\": \"Start je analyse\", \"scan\": \"Start je scan\"};\n  var KEY = \"bp_adv_cta_v\";\n  var HOST = \"app.bioprofile.com\";\n  var el = document.getElementById(\"bp-adv-sitehead-cta\");\n  if (!el) { return; }\n\n  function clean(v) {\n    if (v === \"scan\") { return \"scan\"; }\n    if (v === \"analyse\") { return \"analyse\"; }\n    return null;\n  }\n  function forced() {\n    try {\n      return clean(new URLSearchParams(window.location.search).get(\"bp_cta_force\"));\n    } catch (e) { return null; }\n  }\n  function fromCookie() {\n    var hit = null;\n    String(document.cookie).split(\";\").forEach(function (part) {\n      var kv = part.split(\"=\");\n      if (kv[0].trim() === KEY) { hit = (kv[1] || \"\").trim(); }\n    });\n    return clean(hit);\n  }\n  function held() {\n    var v = null;\n    try { v = localStorage.getItem(KEY); } catch (e) { v = null; }\n    v = clean(v);\n    if (v) { return v; }\n    return fromCookie();\n  }\n  function keep(v) {\n    try { localStorage.setItem(KEY, v); return; } catch (e) {}\n    try {\n      document.cookie = KEY + \"=\" + v + \"; path=\/; max-age=15552000; samesite=lax\";\n    } catch (e) {}\n  }\n\n  var variant = forced();\n  if (!variant) {\n    variant = held();\n    if (!variant) { variant = (Math.random() > 0.5) ? \"scan\" : \"analyse\"; }\n    keep(variant);\n  }\n  el.textContent = TEXT[variant];\n\n  function stamped(href) {\n    var u;\n    try { u = new URL(href, window.location.href); } catch (e) { return null; }\n    if (u.hostname !== HOST) { return null; }\n    u.searchParams.set(\"bp_cta\", variant);\n    return u.toString();\n  }\n  var first = stamped(el.getAttribute(\"href\"));\n  if (first) { el.setAttribute(\"href\", first); }\n\n  function siteHeaderAppLinks() {\n    var out = [];\n    var heads = document.querySelectorAll(\".elementor-location-header\");\n    Array.prototype.forEach.call(heads, function (h) {\n      Array.prototype.forEach.call(h.getElementsByTagName(\"a\"), function (a) {\n        var u;\n        try { u = new URL(a.href); } catch (e) { return; }\n        if (u.hostname === HOST) { out.push(a); }\n      });\n    });\n    return out;\n  }\n  function adopt() {\n    var found = null;\n    var links = document.getElementsByClassName(\"wp-block-button__link\");\n    Array.prototype.forEach.call(links, function (a) {\n      if (found) { return; }\n      var u;\n      try { u = new URL(a.href); } catch (e) { return; }\n      if (u.hostname === HOST) { found = a.href; }\n    });\n    if (!found) { return; }\n    var out = stamped(found);\n    if (out) { el.setAttribute(\"href\", out); }\n    siteHeaderAppLinks().forEach(function (a) { a.setAttribute(\"href\", found); });\n  }\n  if (document.readyState === \"loading\") {\n    document.addEventListener(\"DOMContentLoaded\", adopt);\n  } else {\n    adopt();\n  }\n})();\n<\/script>\n<script id=\"bp-adv-stickycta-offset\">\n(function () {\n  var FALLBACK = 78;\n  var bar = document.querySelector(\".bp-adv-stickycta\");\n  if (!bar) { return; }\n  function header() {\n    var found = null;\n    var all = document.querySelectorAll(\".elementor-location-header\");\n    Array.prototype.forEach.call(all, function (h) {\n      if (found) { return; }\n      if (!h.classList.contains(\"elementor-sticky__spacer\")) { found = h; }\n    });\n    return found;\n  }\n  function set() {\n    var h = header();\n    var n = h ? 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ONE H1, plain text on white; everything else H2 or H3; an H2 may carry its\n      own background colour so the page can be read from the headings alone; an\n      H3 keeps its section background and gets a bigger font size;\n   4. reuse the results page design feel;\n   5. Written by \/ Verified by, the placeholder blocks and noindex stay.\n\n   COLOUR PROVENANCE. Not one hex is invented.\n   - #b7cb32  LIGHT GREEN, brand manual \"colours rejuvenation protocol\"\n              (R183 G203 B51). Same value as --bp-lime in\n              brands\/bioprofile\/brand\/tokens.md.\n   - #006b62  DARK GREEN, brand manual, nourish the cells (R0 G107 B98).\n   - #005859  brand manual primary teal, the value the brand is built on.\n   - #228a62  brand manual, challenge the body (R34 G138 B98).\n   - #7ca64c  brand manual, calm the mind (R124 G166 B76).\n   - #dbd4cd  brand manual \"additional color\", the warm neutral.\n   - #B7CB3329 is the brand token --bp-lime-soft (light green at 16 percent).\n   - the gradients are the brand token layer's own, copied verbatim.\n\n   SPECIFICITY NOTE. Elementor's global kit emits `.elementor-kit-6 h2` style\n   rules at (0,1,1). Element rules below are written `.bp-adv h2`, also (0,1,1),\n   and win on source order because this sheet is inline in the body while the\n   kit is a <link> in the head. Component rules that MUST NOT lose carry two\n   classes, e.g. `.bp-adv .wp-block-button__link`.\n\n   LAYOUT NOTE. Vertical rhythm uses `margin-block` and never the `margin`\n   shorthand, so the measure rule `.bp-adv-sec > * { margin-inline: auto }` can\n   centre a block without being outranked by its own element rule.\n   =========================================================================== *\/\n\n.bp-adv {\n  --bp-ink: #212527;\n  --bp-teal: #005859;\n  --bp-forest: #006B62;\n  --bp-emerald: #228A62;\n  --bp-olive: #7CA64C;\n  --bp-lime: #B7CB33;\n  --bp-lime-soft: #B7CB3329;\n  --bp-sand: #DBD4CB;\n  --bp-white: #FFFFFF;\n  --bp-foot: #6b6b6b;\n  --bp-grad-dark: linear-gradient(237deg, rgba(0,88,89,0.00) 62.94%, #005859 100%), linear-gradient(90deg, rgba(34,138,98,0.00) 40%, #228A62 100%), #006B62;\n  --bp-grad-lime: linear-gradient(110deg, rgba(183,203,51,0.00) 36.06%, rgba(183,203,51,0.25) 97.65%), #FFFFFF;\n  --bp-font: 'Poppins','Segoe UI',Arial,sans-serif;\n  --bp-fs-h1: 44px; --bp-fs-h2: 31px; --bp-fs-h3: 24px; --bp-fs-pre: 15px;\n  --bp-fs-body: 17px; --bp-fs-small: 14px; --bp-fs-foot: 13px; --bp-fs-btn: 17px;\n  --bp-lh-body: 1.75;\n  --bp-s-1: 4px; --bp-s-2: 8px; --bp-s-3: 12px; --bp-s-4: 16px;\n  --bp-s-5: 24px; --bp-s-6: 32px; --bp-s-7: 44px; --bp-s-8: 72px;\n  --bp-measure: 760px; --bp-side: 40px;\n  --bp-radius-photo: 16px; --bp-radius-btn: 10px; --bp-radius-card: 20px;\n  --bp-shadow: 0 10px 30px rgba(0,88,89,0.10);\n  font-family: var(--bp-font);\n  font-size: var(--bp-fs-body);\n  line-height: var(--bp-lh-body);\n  color: var(--bp-ink);\n  background: var(--bp-white);\n  -webkit-font-smoothing: antialiased;\n}\n.bp-adv, .bp-adv * { box-sizing: border-box; }\n.bp-adv p, .bp-adv li, .bp-adv h1, .bp-adv h2, .bp-adv h3, .bp-adv blockquote,\n.bp-adv a, .bp-adv cite, .bp-adv span { overflow-wrap: break-word; min-width: 0; }\n\n\/* THE TOGGLE. 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Jesse asked for a second H1 here; the brand\n   doc's accessibility rule is one h1 per page, so it is rendered at H1 size and\n   stays an h2 element. Named in the close as the one design conflict. *\/\n.bp-adv h2.bp-adv-offerhead {\n  font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); text-align: center; color: var(--bp-ink);\n  background: none; padding: 0; border: 0; border-radius: 0;\n}\n\n\/* --- Written by + Verified by. The avatar is the first child and spans the\n       three text rows, so the whole box is four ordinary paragraphs and stays\n       editable without nested columns. ---------------------------------------- *\/\n.bp-adv .bp-adv-authors {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-top: 4px solid var(--bp-lime); border-radius: var(--bp-radius-card);\n  box-shadow: var(--bp-shadow); padding: var(--bp-s-5);\n  margin-block: 0 var(--bp-s-4);\n  \/* auto-fit, so switching the verified box off leaves one full-width author\n     rather than a half-empty card *\/\n  display: grid; grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));\n  gap: var(--bp-s-5); align-items: start;\n}\n.bp-adv .bp-adv-author {\n  display: grid; grid-template-columns: 62px 1fr; gap: 0 var(--bp-s-3);\n  align-items: start; min-width: 0;\n}\n.bp-adv .bp-adv-avatar {\n  grid-row: 1 \/ span 3; width: 62px; height: 62px; border-radius: 50%;\n  background: #B7CB331F; border: 2px dashed var(--bp-olive);\n  display: flex; align-items: center; justify-content: center;\n  font-size: 10px; font-weight: 700; letter-spacing: 0.06em; color: var(--bp-forest);\n  margin-block: 0;\n}\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-avatar {\n  border-color: var(--bp-sand); background: #fff; color: var(--bp-foot); }\n.bp-adv .bp-adv-author-role {\n  font-size: 11px; font-weight: 700; letter-spacing: 0.08em; text-transform: uppercase;\n  color: var(--bp-forest); line-height: 1.6; margin-block: 0; }\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-author-role { color: var(--bp-foot); }\n.bp-adv .bp-adv-author-name { font-size: 17px; font-weight: 700; line-height: 1.35;\n  margin-block: 0; }\n.bp-adv .bp-adv-author-cred { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.55; margin-block: 0; }\n\/* the optional wrapper must not break the two-column grid of the box *\/\n.bp-adv .bp-adv-authors > .bp-optional { display: contents; }\n.bp-adv .bp-adv-authors > .bp-optional.bp-off { display: none !important; }\n\n\/* --- placeholders: image slot, video slot ---------------------------------- *\/\n.bp-adv .bp-slot {\n  display: flex; align-items: center; justify-content: center; text-align: center;\n  min-height: 180px; padding: var(--bp-s-4); margin-block: var(--bp-s-5) 0;\n  border: 2px dashed var(--bp-olive); border-radius: var(--bp-radius-photo);\n  background: #B7CB331F; color: var(--bp-forest);\n}\n.bp-adv .bp-slot p { font-size: var(--bp-fs-small); font-weight: 700; margin-block: 0; }\n.bp-adv .bp-slot--video { min-height: 260px; }\n\n\/* --- mid-article CTA band --------------------------------------------------- *\/\n.bp-adv .bp-adv-midcta {\n  background: var(--bp-grad-lime); border: 1px solid var(--bp-lime);\n  border-radius: var(--bp-radius-card); padding: var(--bp-s-5) var(--bp-s-4);\n  margin-block: var(--bp-s-6); text-align: center;\n}\n.bp-adv .bp-adv-midcta .wp-block-buttons { margin-block-end: var(--bp-s-2); }\n.bp-adv .bp-adv-midcta .bp-adv-foot { margin-block: 0; }\n\n\/* the closing CTA is one named unit in List View, so it moves and toggles as a\n   whole. It carries no box of its own: the spacing must read exactly as it does\n   on the approved page, where the three parts are plain siblings. *\/\n.bp-adv .bp-adv-ctablock { margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-ctablock .wp-block-buttons { margin-block-end: var(--bp-s-4); }\n.bp-adv .bp-adv-ctablock .bp-adv-foot { margin-block: 0; }\n\n\/* --- the condition, slot 8: the results page reference-card shape ----------- *\/\n.bp-adv .bp-adv-condition {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-left: 5px solid var(--bp-lime); border-radius: var(--bp-radius-btn);\n  padding: var(--bp-s-4) var(--bp-s-5); font-weight: 600; box-shadow: var(--bp-shadow);\n}\n\n\/* --- the numbers card: the results page focus panel, same gradient, same\n       radius, same lime figures (\"use more of that design\") ------------------ *\/\n.bp-adv .bp-adv-numcard {\n  background: linear-gradient(135deg, var(--bp-teal) 0%, var(--bp-forest) 100%);\n  border-radius: var(--bp-radius-card);\n  padding: var(--bp-s-6) var(--bp-s-5) var(--bp-s-5);\n  box-shadow: var(--bp-shadow); margin-block: var(--bp-s-5) 0;\n  position: relative; overflow: hidden;\n}\n.bp-adv .bp-adv-numcard::after {\n  content: \"\"; position: absolute; right: -70px; top: -70px; width: 240px; height: 240px;\n  border-radius: 50%; background: rgba(255,255,255,0.05); pointer-events: none;\n}\n.bp-adv .bp-adv-numcard .wp-block-columns {\n  position: relative; z-index: 1; gap: var(--bp-s-5); margin-block: 0; }\n.bp-adv .bp-adv-numcard .wp-block-column { min-width: 0; }\n.bp-adv .bp-adv-num-v { font-size: 44px; font-weight: 700; line-height: 1.12;\n  color: var(--bp-lime); text-align: center; margin-block: 0 var(--bp-s-2); }\n.bp-adv .bp-adv-num-l { font-size: var(--bp-fs-small); line-height: 1.5;\n  color: rgba(255,255,255,0.92); text-align: center; margin-block: 0; }\n.bp-adv .bp-adv-numsrc { margin-block: var(--bp-s-5) 0; }\n\n\/* --- the proof slot: a dashed card until a consented quote exists. The quote\n       inside loses its own vertical margins, otherwise the card is one full\n       block of spacing taller than the approved page. --------------------- *\/\n.bp-adv .bp-adv-testimonial {\n  border: 1px dashed var(--bp-sand); border-left: 5px dashed var(--bp-sand);\n  background: var(--bp-white); border-radius: var(--bp-radius-card);\n  padding: var(--bp-s-5); margin-block: var(--bp-s-5);\n}\n\/* the card IS the quote frame, so the quote inside it carries no rule and no\n   indent of its own; otherwise the copy is indented twice and wraps early *\/\n.bp-adv .bp-adv-testimonial .wp-block-quote {\n  border: 0; padding: 0; margin-block: 0; }\n.bp-adv .bp-adv-testimonial .wp-block-quote p {\n  font-size: 17px; font-weight: 500; color: var(--bp-foot); }\n\n\/* --- steps, footnotes, disclosure ------------------------------------------- *\/\n.bp-adv .bp-adv-steps {\n  max-width: 520px; margin-block: 0 var(--bp-s-5); margin-inline: auto;\n  padding-left: 0; list-style: none; counter-reset: bpstep; text-align: left;\n}\n.bp-adv .bp-adv-steps li { position: relative; padding-left: 40px;\n  margin-block-end: var(--bp-s-3); counter-increment: bpstep; }\n.bp-adv .bp-adv-steps li::before {\n  content: counter(bpstep); position: absolute; left: 0; top: 4px;\n  width: 26px; height: 26px; border-radius: 50%;\n  background: var(--bp-forest); color: var(--bp-white);\n  font-size: var(--bp-fs-small); font-weight: 700;\n  display: flex; align-items: center; justify-content: center; line-height: 1;\n}\n.bp-adv .bp-adv-foot { font-size: var(--bp-fs-foot); color: var(--bp-foot); line-height: 1.6; }\n.bp-adv-sec--dark .bp-adv-foot { color: rgba(255,255,255,0.82); }\n\/* Jesse's mandatory CTA subtext, 2026-07-30 15:59: directly under the button,\n   one notch above the microline in weight so it reads as part of the ask *\/\n.bp-adv .bp-adv-ctasub {\n  margin-block: calc(var(--bp-s-4) * -0.5) var(--bp-s-2); margin-inline: auto;\n  max-width: 460px; font-size: 15px; line-height: 1.5; font-weight: 600;\n  color: var(--bp-teal); text-align: center;\n}\n.bp-adv .bp-adv-disclosure { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.6; }\n.bp-adv .bp-adv-sources { margin-block-start: var(--bp-s-5); }\n.bp-adv .bp-adv-srclist { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.6; padding-left: 20px; margin-block: 0; }\n.bp-adv .bp-adv-srclist li { margin-block-end: var(--bp-s-1); }\n.bp-adv .bp-h--center { text-align: center; }\n\n@media (max-width: 767px) {\n  .bp-adv {\n    --bp-fs-h1: 30px; --bp-fs-h2: 24px; --bp-fs-h3: 20px; --bp-fs-body: 16px;\n    --bp-fs-btn: 16px; --bp-fs-pre: 14px; --bp-side: 20px;\n    --bp-s-8: 44px; --bp-s-7: 32px;\n  }\n  .bp-adv .bp-adv-subheadline { font-size: 18px; }\n  .bp-adv .bp-adv-standfirst { font-size: 17px; }\n  .bp-adv .bp-adv-lede { font-size: 16px; }\n  .bp-adv .wp-block-pullquote p, .bp-adv .wp-block-quote p { font-size: 20px; }\n  .bp-adv h2 { padding: var(--bp-s-3) var(--bp-s-4); }\n  .bp-adv .bp-adv-num-v { font-size: 36px; }\n  .bp-adv .bp-adv-authors { grid-template-columns: 1fr; gap: var(--bp-s-5); }\n  \/* the button is full width on mobile. Core wraps the link in .wp-block-button,\n     which is shrink-to-fit, so widening only the link leaves it content-sized. *\/\n  .bp-adv .wp-block-button { width: 100%; }\n  .bp-adv .wp-block-button__link { padding: 15px 24px; width: 100%; }\n  .bp-adv .bp-adv-numcard .wp-block-columns { gap: var(--bp-s-4); }\n}\n@media (prefers-reduced-motion: reduce) { .bp-adv * { transition-duration: 0ms; } }\n\n\/* --- the author portrait -----------------------------------------------------\n   Two shapes, because there are two ways a portrait reaches the box.\n   1. `bp-adv-avatar--photo` turns the dashed FOTO circle into a photo frame when\n      an editor drops an inline image into the placeholder paragraph.\n   2. `bp-adv-avatar-img` is the shipped path: a REAL core\/image block, so the\n      picture is click-editable and \"Vervangen\" works. The grid-row span is the\n      load-bearing line. The paragraph avatar carries `grid-row: 1 \/ span 3` in\n      the 62px + 1fr card grid; a figure that does not carry it drops the name\n      under the photo instead of beside it. Found by screenshot on 2026-07-30\n      and fixed on the live page with exactly this rule. ---------------------- *\/\n.bp-adv-avatar--photo{border-style:solid;padding:0;overflow:hidden;background:#fff}\n.bp-adv-avatar--photo img{width:100%;height:100%;object-fit:cover;object-position:center;border-radius:50%;display:block}\n.bp-adv-author .bp-adv-avatar-img{grid-row:1 \/ span 3;flex:0 0 auto;margin:0;width:62px;height:62px}\n.bp-adv-author .bp-adv-avatar-img img{width:62px;height:62px;object-fit:cover;object-position:center;border-radius:50%;border:2px solid var(--bp-olive);display:block}\n\n\/* --- the advertorial's own chrome (synced patterns 4822 and 4823) ------------\n   Deliberately NOT scoped to `.bp-adv`: the header and footer are siblings of\n   the article, outside that container, because canvas gives the page no chrome\n   of its own. A <style> element styles the whole document wherever it sits, so\n   these rules reach the two pattern references either side of the article. --- *\/\n.bp-adv-sitehead{background:#fff;border-bottom:1px solid #e6ece9;padding:12px 24px;margin:0}\n.bp-adv-sitehead .bp-adv-sitehead-logo{margin:0 auto;max-width:1120px}\n.bp-adv-sitehead img{height:30px;width:auto;display:block}\n.bp-adv-sitefoot{background:#f4f1ec;border-top:1px solid #e6ece9;padding:28px 24px;margin-top:44px}\n.bp-adv-sitefoot p{max-width:1120px;margin:0 auto;font-size:13px;line-height:1.8;color:#4d5f5d;text-align:center}\n.bp-adv-sitefoot a{color:#005859;text-decoration:underline}\n.bp-adv-sitefoot .bp-adv-sitefoot-legal{margin-top:6px}\n\n\/* T229 *\/\n\n\/* T170: the sticky header CTA. Jesse 2026-08-24 18:35. *\/\n\/* WHY THIS RULE EXISTS AND WHY IT IS FIRST. The theme ships\n   `body, html { overflow-x: hidden }` as an inline head style. overflow-x:hidden\n   forces the OTHER axis from visible to auto, so html and body both become\n   scroll containers, and a sticky element sticks to its nearest scrollport: the\n   bar was pinned to a box as tall as the whole document, which never scrolls.\n   Measured on this preview 2026-08-24: position:sticky applied, computed top 0,\n   and the bar still left the screen at y=-600 after a 600px scroll. `clip`\n   clips exactly the same overflow WITHOUT creating a scroll container, so the\n   viewport is the scrollport again and the bar sticks. Equal specificity to the\n   theme rule and later in document order, which is what wins it; a browser too\n   old for `clip` keeps `hidden` and a bar that scrolls away, which is the old\n   page and never a broken one. *\/\nhtml,body{overflow-x:clip}\n.bp-adv-sitehead.wp-block-group{position:sticky;top:0;z-index:120;background:#fff;\n  border-bottom:1px solid #e6ece9;padding:12px 24px;margin:0}\n.bp-adv-sitehead.wp-block-group>*{margin-block:0}\n.bp-adv-sitehead.is-stuck{box-shadow:0 2px 10px rgba(0,88,89,0.08)}\n.bp-adv-sitehead .bp-adv-sitehead-row{max-width:1120px;margin:0 auto;display:flex;\n  align-items:center;justify-content:space-between;gap:12px}\n.bp-adv-sitehead .bp-adv-sitehead-row>*{margin-block:0}\n.bp-adv-sitehead .bp-adv-sitehead-row .bp-adv-sitehead-logo{margin:0;max-width:none;\n  flex:0 0 auto;line-height:0}\na.bp-adv-sitehead-cta{display:inline-flex;align-items:center;justify-content:center;\n  flex:0 0 auto;min-height:40px;padding:0 22px;border-radius:999px;\n  background:#005859;color:#fff;font-family:'Poppins','Segoe UI',Arial,sans-serif;\n  font-size:15px;font-weight:600;line-height:1.2;white-space:nowrap;\n  text-decoration:none;transition:background 250ms ease}\na.bp-adv-sitehead-cta:hover,a.bp-adv-sitehead-cta:focus{background:#7CA64C;color:#fff}\na.bp-adv-sitehead-cta:focus-visible{outline:2px solid #005859;outline-offset:2px}\n\/* T188: the text link to the scans index, beside the pill. margin-left:auto takes\n   the row's free space, so link and pill sit together at the right edge and the\n   logo stays where it is. Same 40px tap height as the pill. *\/\na.bp-adv-sitehead-nav{display:inline-flex;align-items:center;margin-left:auto;\n  flex:0 0 auto;min-height:40px;padding:8px 4px;\n  font-family:'Poppins','Segoe UI',Arial,sans-serif;font-size:15px;font-weight:600;\n  line-height:1.2;color:#005859;white-space:nowrap;text-decoration:none}\na.bp-adv-sitehead-nav:hover,a.bp-adv-sitehead-nav:focus{color:#7CA64C;text-decoration:underline}\na.bp-adv-sitehead-nav:focus-visible{outline:2px solid #005859;outline-offset:2px}\n@media (max-width:767px){\n  .bp-adv-sitehead.wp-block-group{padding:12px 20px}\n  .bp-adv-sitehead .bp-adv-sitehead-row{gap:10px}\n  a.bp-adv-sitehead-nav{font-size:14px}\n  a.bp-adv-sitehead-cta{font-size:14px;padding:0 16px}\n}\n@media (prefers-reduced-motion:reduce){a.bp-adv-sitehead-cta{transition-duration:0ms}}\n\nhtml,body{overflow-x:clip}\n.bp-adv .bp-adv-stickycta{position:sticky;top:var(--bp-adv-stickycta-top,78px);\n  z-index:110;background:#fff;border-bottom:1px solid #e6ece9;padding:10px 20px;margin:0}\n.bp-adv .bp-adv-stickycta>*{margin-block:0}\n.bp-adv .bp-adv-stickycta-row{max-width:1120px;margin:0 auto;display:flex;\n  align-items:center;justify-content:flex-end;gap:12px}\n@media (min-width:768px){\n  .bp-adv .bp-adv-stickycta{display:none}\n  .bp-adv .bp-adv-stickycta+*{margin-block-start:0}\n}\n<\/style>\n<script id=\"bp-adv-attribution\">\n(function () {\n  var HOST = \"app.bioprofile.com\";\n  var KEYS = [\"utm_content\", \"bp_pl\"];\n  function forward() {\n    var q = new URLSearchParams(window.location.search);\n    var carry = [];\n    KEYS.forEach(function (k) {\n      var v = q.get(k);\n      if (v) { carry.push([k, v]); }\n    });\n    if (!carry.length) { return; }\n    var links = document.getElementsByTagName(\"a\");\n    Array.prototype.forEach.call(links, function (a) {\n      var u;\n      try { u = new URL(a.href); } catch (e) { return; }\n      if (u.hostname !== HOST) { return; }\n      carry.forEach(function (kv) { u.searchParams.set(kv[0], kv[1]); });\n      a.setAttribute(\"href\", u.toString());\n    });\n  }\n  if (document.readyState === \"loading\") {\n    document.addEventListener(\"DOMContentLoaded\", forward);\n  } else {\n    forward();\n  }\n})();\n<\/script>\n<script id=\"bp-adv-first-touch\" src=\"https:\/\/app.bioprofile.com\/app\/js\/first-touch.js\"><\/script>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity bp-adv-rule\"\/>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--hero bp-adv-sec--paper is-layout-flow wp-block-group-is-layout-flow\">\n\n<p class=\"bp-adv-preheadline wp-block-paragraph\">Published research on joint ageing \u00b7 Read this before you buy another jar<\/p>\n\n\n\n<h1 class=\"wp-block-heading bp-adv-h1\">\"Wear and tear.\" That is the word you have been hearing for twenty years. In 2016 researchers put a different explanation on paper: the cells that maintain your joints have started doing other work. That changes your first step.<\/h1>\n\n\n\n<p class=\"bp-adv-subheadline wp-block-paragraph\">No new supplement. No waiting half a year to notice something. A free five minute check that shows which signals in your own answers speak loudest.<\/p>\n\n\n\n<div class=\"wp-block-group bp-adv-authors is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-group bp-adv-author is-layout-flow wp-block-group-is-layout-flow\">\n\n<figure class=\"wp-block-image size-full is-resized bp-adv-avatar-img\"><img decoding=\"async\" src=\"https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/07\/author-jesse-round-320.jpg\" alt=\"Jesse van der Velde\" class=\"wp-image-4815\" width=\"62\" height=\"62\" srcset=\"https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/07\/author-jesse-round-320.jpg 320w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/07\/author-jesse-round-320-300x300.jpg 300w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/07\/author-jesse-round-320-150x150.jpg 150w\" sizes=\"(max-width: 62px) 100vw, 62px\" \/><\/figure>\n\n\n\n<p class=\"bp-adv-author-role wp-block-paragraph\">Written by<\/p>\n\n\n\n<p class=\"bp-adv-author-name wp-block-paragraph\">Jesse van der Velde<\/p>\n\n\n\n<p class=\"bp-adv-author-cred wp-block-paragraph\">Founder of BioProfile \u00b7 15 books, 2 of them number 1 bestsellers \u00b7 has guided more than 500,000 people since 2006<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-optional bp-off is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-group bp-adv-author is-placeholder is-layout-flow wp-block-group-is-layout-flow\">\n\n<p class=\"bp-adv-avatar wp-block-paragraph\">PHOTO<\/p>\n\n\n\n<p class=\"bp-adv-author-role wp-block-paragraph\">Scientifically verified by<\/p>\n\n\n\n<p class=\"bp-adv-author-name wp-block-paragraph\">[NAME TO FOLLOW]<\/p>\n\n\n\n<p class=\"bp-adv-author-cred wp-block-paragraph\">Dutch doctor (MD) or PhD \u00b7 independent check of every advertorial<\/p>\n\n<\/div>\n\n<\/div>\n\n<\/div>\n\n\n\n<p class=\"bp-adv-byline wp-block-paragraph\">8 min read<\/p>\n\n\n\n<p class=\"bp-adv-lede wp-block-paragraph\">\"I'm just worn out. That's it.\"<\/p>\n\n\n\n<p class=\"bp-adv-lede wp-block-paragraph\">Say that sentence out loud.<\/p>\n\n\n\n<p class=\"bp-adv-lede wp-block-paragraph\">It sits close to what you think when you have to stand still for a moment at the top of the stairs. Or when your fingers are stiff in the morning as you pick up your coffee.<\/p>\n\n\n\n<p class=\"bp-adv-lede wp-block-paragraph\">I am Jesse van der Velde. Not a guru and not a doctor. I study and share what published research says about how a body ages. I have been testing that on myself and with the people I guide for more than fourteen years.<\/p>\n\n\n\n<div class=\"wp-block-group bp-optional is-layout-flow wp-block-group-is-layout-flow\">\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1520\" height=\"1009\" src=\"https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-duinpad.webp\" alt=\"A woman aged 60-something, with short white hair and a light blue raincoat, walks along a narrow sandy path between overgrown dunes.\" class=\"wp-image-6040\" srcset=\"https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-duinpad.webp 1520w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-duinpad-300x199.webp 300w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-duinpad-1024x680.webp 1024w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-duinpad-768x510.webp 768w\" sizes=\"(max-width: 1520px) 100vw, 1520px\" \/><\/figure>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-optional bp-slot bp-slot--video bp-off is-layout-flow wp-block-group-is-layout-flow\">\n\n<p class=\"wp-block-paragraph\">VIDEO SLOT \u00b7 place a video or embed here<\/p>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--prose bp-adv-sec--paper bp-adv-rail bp-adv-rail--left is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\">What \"wear and tear\" means, and why it made you buy the wrong thing<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\"Wear and tear\" means used up. Too many years, too many stairs, too much tennis in your thirties.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If the material (the substances in your joints) has run out, the next step is obvious. Spare the joint. Top the material up. Buy the jar with the knee on the label.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That is how the shop is laid out: building materials in powder form, with a whole industry built around them.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is one problem in that story.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Your cartilage is living tissue, maintained by cells that build the tissue up and clear away damaged parts. Below, I call that work \"joint maintenance\".<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research of the past decade points to those cells. The material comes only after that.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Maybe you think: \"Well, that is just age.\"<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">But that is not true.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--prose bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\">What the 2016 study really found in ageing joints<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In 2016, three researchers led by Richard Loeser published a study on what growing older does to joints.\u00b9<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">What was studied: the mechanisms through which ageing contributes to joint complaints.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">How: this is a meta study. No trial of their own and no participants. The authors describe no search strategy and no selection criteria, and what they discuss is largely about cartilage.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The findings: five changes that run at the same time in an ageing joint and together produce one outcome, more breakdown and less repair.<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n\n<li>Mild inflammatory activity that keeps going over the years.<\/li>\n\n\n<li>Cartilage cells that pass into an aged state and give off substances that break tissue down.<\/li>\n\n\n<li>Mitochondria, the parts that supply the cell with energy, start to work less well, and oxidative stress builds up.<\/li>\n\n\n<li>Less activity from AMPK, the protein that regulates the energy balance, which makes the clean-up inside the cell run more slowly.<\/li>\n\n\n<li>Changes in the tissue around the cell, which change the signals the cell takes in.<\/li>\n\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">Read that list again. Nowhere does it say \"used up\". The cells that did the joint maintenance change their behaviour.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The authors add themselves that growing older and joint complaints are closely linked, but are two separate processes. So growing older does not produce those complaints by itself.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is a separate review article about that oxidative stress. Henrotin, Kurz and Aigner published in 2005 on reactive oxygen species, molecules that form in every cell as soon as that cell uses oxygen.\u00b2<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">What was studied: what oxygen and those molecules do to cartilage cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">How: a systematic search in Medline, after which the authors set out the published research on cells in the laboratory and in living tissue. Here too, no patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The findings: the same molecules do two opposite things, and the amount decides which of the two. At normal levels they belong to the ordinary jobs of the cartilage cell: activating the cell, cell division, and reshaping the tissue around it, which involves both building up and breaking down. As soon as production becomes greater than what the cell clears away, what the authors call \"oxidative stress\" sets in, and those same cells are damaged.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Which side your own body is on is not something you can feel from the inside.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The authors are honest about how far that reaches: they themselves call the precise role of oxidative stress in cartilage breakdown still unclear.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For twenty years you were handed a story you could do nothing about. Cell behaviour does respond to load, muscle strength and weight.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That makes the process something you can tackle.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Does this sound familiar?<\/strong> Take the free check now.<\/p>\n\n\n\n<div class=\"wp-block-group bp-adv-midcta is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/app.bioprofile.com\/mini?scan=healthy-aging&amp;utm_source=advertorial&amp;utm_medium=page&amp;utm_campaign=niet-versleten-je-cellen-zijn-ander-werk-gaan-doen&amp;lang=en\">Start your analysis now<\/a><\/div>\n\n<\/div>\n\n\n\n<p class=\"bp-adv-foot wp-block-paragraph\">Our scientifically validated questionnaire gives you answers<\/p>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--prose bp-adv-sec--paper is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\">How big this is, in three published figures<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>654.1 million.<\/strong> In 2020 a meta-analysis by Cui and colleagues appeared: 88 population studies with 10,081,952 participants between them, searched in PUBMED, EMBASE and SCOPUS up to and including 4 April 2020. Long-term knee complaints occurred in 22.9 per cent of people aged 40 and over, about 654.1 million worldwide.\u00b3<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That number is a calculation and not a count: the authors put a 95 per cent confidence interval with it, of 565.6 to 745.6 million. It says how many people are walking around with it, and nothing about what is going on with you.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>11th of 291.<\/strong> The Global Burden of Disease programme published the calculation by Cross and colleagues in 2014. They gathered figures by age and sex through systematic reviews, and ran those through a model per country for 1990 and 2010. Of the 291 conditions counted, hip and knee complaints stood 11th in 2010 among the largest causes of disability worldwide.\u2074<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The authors note themselves that problems in their method make it very likely that the true burden has been underestimated. That 11th place is a lower limit.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1.69 times.<\/strong> The same 2020 meta-analysis found long-term knee complaints 1.69 times as often in women as in men (95 per cent confidence interval 1.59 to 1.80).\u00b3<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Are you a woman over fifty? Then that difference was already there in the figures, and nobody told you.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--prose bp-adv-sec--paper bp-adv-rail bp-adv-rail--right is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\">The two minutes at the top of the stairs<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">You know your own version of this. The version I heard from older family around me came out of a hotel where we were with the family: two flights of stairs to breakfast, and over the first six steps my grandmother moved stiffly and slowly.<\/p>\n\n\n\n<div class=\"wp-block-group bp-optional is-layout-flow wp-block-group-is-layout-flow\">\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1520\" height=\"1009\" src=\"https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-man-beukenbos.webp\" alt=\"A man of around 70 with grey hair combed back and a dark green quilted jacket walks along a forest path between tall beech trees.\" class=\"wp-image-6041\" srcset=\"https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-man-beukenbos.webp 1520w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-man-beukenbos-300x199.webp 300w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-man-beukenbos-1024x680.webp 1024w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-man-beukenbos-768x510.webp 768w\" sizes=\"(max-width: 1520px) 100vw, 1520px\" \/><\/figure>\n\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\"I'm just worn out\" turns two slow minutes into a verdict on the rest of your life.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Then you adapt. You take the lift. You stop saying yes to the walk.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">What you felt is real. For that verdict there is no evidence.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research describes a process that is running. And with a process, you can work out where it stands.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--prose bp-adv-sec--paper is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\">What you have already tried, and what each of those attempts did not solve<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1. The jar of building blocks.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The reasoning was supply: the material is gone, so eat the material. There is a kernel of truth in that. It helps. But it is not the whole story, you have to look further as well.<\/p>\n\n\n\n<div class=\"wp-block-group bp-optional is-layout-flow wp-block-group-is-layout-flow\">\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1520\" height=\"1009\" src=\"https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-volkstuin.webp\" alt=\"A woman of around 60 with grey hair in a bun and a linen apron stands in a vegetable garden among herbs and bean poles, holding a bunch of fresh herbs.\" class=\"wp-image-6042\" srcset=\"https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-volkstuin.webp 1520w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-volkstuin-300x199.webp 300w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-volkstuin-1024x680.webp 1024w, https:\/\/bioprofile.com\/wp-content\/uploads\/2026\/09\/stijve-gewrichten-vrouw-volkstuin-768x510.webp 768w\" sizes=\"(max-width: 1520px) 100vw, 1520px\" \/><\/figure>\n\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">In 2006 Bello and Oesser looked at the literature on collagen hydrolysate: a search in PubMed up to May 2006, plus conference abstracts and German-language articles they considered relevant themselves. So not a systematic review. They found four open and three double-blind studies. Collagen hydrolysate is absorbed in the gut and builds up in cartilage, and cartilage cells in the laboratory go on to make more building blocks because of it (p less than 0.05 against untreated cells). In those seven studies it proved safe, and in some men and women it gave improvement on some measures of pain and function.\u2075<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Only, the authors add themselves that many of those studies did not state whether their result was statistically significant. They call their conclusion a reason to consider it, and not proof that it works.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">So you were not foolish to buy it. It is just that a jar gives you no answer to the question of which of those five plays the biggest role in you.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2. Taking it easier.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If the problem is wear and tear, rest makes sense. But be clear about what rest does and does not do. At that moment it takes the load away. It does not tell you which of the processes above speaks loudest in your case, and sparing a joint for a long time also takes away the load your muscles need.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In 2016 Briggs and colleagues wrote a report in <strong>The Gerontologist<\/strong> for the World Health Organization's 2015 world report on ageing. There are more than 150 kinds of conditions of the muscles, bones and joints. Their core point: painful complaints from these are strongly linked to being less able to move, and what follows is decline in functioning, frailty, less wellbeing and loss of independence.\u2076<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Rest leads to less movement, and that is exactly what this report points to as the problem. Note as well what it cannot say: there is no research of its own behind it, so it describes a direction and does not prove that anything works.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3. \"It's my age, there's nothing to be done about it.\"<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Newman and colleagues followed 2,292 people aged 70 to 79, and published that in 2006 in the <strong>Journals of Gerontology<\/strong>. Here strength and muscle size were measured in the same people: strength with strength meters, size with a CT scan and a DXA scan. After that they kept track of who died. 286 people died over an average of 4.9 years. Strength was closely linked to death: for every standard deviation less knee strength, 38 newton metres, the chance of dying was 1.51 times as high in men (95 per cent confidence interval 1.28 to 1.79) and 1.65 times as high in women (1.19 to 2.30). Muscle size was not closely linked to death in this study.\u2077<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Correcting for muscle size barely changed the link with strength.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nobody was trained. This is a group that was followed, so it holds a link and not a cause: within the same age group, strength was linked to mortality, and muscle size was not.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4. Waiting the year out.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Give it time, see how it develops. But a process with a direction does not pause while you wait. The report in The Gerontologist points in one direction: less movement, and after that a loss of independence.\u2076<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Four answers, one shared problem: not one of them looked at what is going on in your case.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The story about wear and tear is not right, so neither is the approach that followed from it. That approach has failed. You have done nothing wrong. It can be done differently.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--prose bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\">The first step the research points to is an analysis, and a product cannot do that<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This is the heart of it. If joint ageing is five processes running at the same time, \"which jar\" is no longer a useful question.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The question becomes: <strong>which of those five plays the biggest role in me right now?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Inflammatory activity that keeps going asks for something different from a joint that is loaded wrongly because of too little muscle strength. From the inside, both feel like the same stiff morning.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That is new. The 2016 review article listed those five processes side by side and made them nameable.\u00b9<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">What was not there: a way to hold your own situation up against that list.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On one condition. An analysis like that has to be about you: your symptoms, your pattern, laid question by question alongside those processes. A general list of joint tips does not tell you which of those five plays the biggest part in your case.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--prose bp-adv-sec--dark is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\">A free, validated questionnaire, five minutes, no account<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">BioProfile has built that first step. A scientifically validated questionnaire, five minutes, free and with no account.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">You answer questions about your body and your daily life. After that you see which signals in your profile speak loudly, and what the research says about them.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Not a medical examination. An analysis of your own answers. You use the outcome yourself, or you put it on the table with your doctor or your coach.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">None of the four routes above started from your own situation.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--cta bp-adv-sec--offer is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading bp-adv-offerhead\">What you can do before your coffee goes cold<\/h2>\n\n\n\n<p class=\"bp-h--center wp-block-paragraph\">You do the free check. Five minutes, no account, and there is nothing to buy.<\/p>\n\n\n\n<p class=\"bp-h--center wp-block-paragraph\">Even if you do nothing with it, you have traded \"I am just worn out\" for an analysis of your own answers. That trade is worth five minutes.<\/p>\n\n\n\n<p class=\"bp-h--center wp-block-paragraph\">And the next time you stop at the top of the stairs, you will know which signals in your profile speak loudest.<\/p>\n\n\n\n<p class=\"bp-h--center wp-block-paragraph\">Do it while this page is still open. The process carries on as long as you wait.<\/p>\n\n\n\n<div class=\"wp-block-group bp-adv-ctablock is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/app.bioprofile.com\/mini?scan=healthy-aging&amp;utm_source=advertorial&amp;utm_medium=page&amp;utm_campaign=niet-versleten-je-cellen-zijn-ander-werk-gaan-doen&amp;lang=en\">Start your scan (questionnaire)<\/a><\/div>\n\n<\/div>\n\n\n\n<p class=\"bp-adv-ctasub wp-block-paragraph\">Our scientifically validated questionnaire gives you answers<\/p>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--disclosure bp-adv-sec--paper is-layout-flow wp-block-group-is-layout-flow\">\n\n<p class=\"bp-adv-disclosure wp-block-paragraph\">The scan is not a medical examination. It is an analysis of your own answers. If complaints persist, consult your doctor.<\/p>\n\n\n\n<h3 class=\"wp-block-heading bp-adv-sources\">Sources<\/h3>\n\n\n\n<ol class=\"wp-block-list bp-adv-srclist\">\n\n<li>Loeser RF, Collins JA, Diekman BO (2016). Ageing and the pathogenesis of osteoarthritis. <em>Nature Reviews Rheumatology<\/em> 12(7):412-420. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27192932\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/27192932\/<\/a><\/li>\n\n\n<li>Henrotin Y, Kurz B, Aigner T (2005). Oxygen and reactive oxygen species in cartilage degradation: friends or foes? <em>Osteoarthritis and Cartilage<\/em> 13(8):643-654. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15936958\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/15936958\/<\/a><\/li>\n\n\n<li>Cui A, et al. (2020). Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. <em>EClinicalMedicine<\/em> 29-30:100587. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34505846\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34505846\/<\/a><\/li>\n\n\n<li>Cross M, et al. (2014). The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. <em>Annals of the Rheumatic Diseases<\/em> 73(7):1323-1330. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24553908\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24553908\/<\/a><\/li>\n\n\n<li>Bello AE, Oesser S (2006). Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. <em>Current Medical Research and Opinion<\/em> 22(11):2221-2232. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17076983\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17076983\/<\/a><\/li>\n\n\n<li>Briggs AM, et al. (2016). Musculoskeletal health conditions represent a global threat to healthy aging. <em>The Gerontologist<\/em> 56(Suppl 2):S243-S255. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26994264\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/26994264\/<\/a><\/li>\n\n\n<li>Newman AB, et al. (2006). Strength, but not muscle mass, is associated with mortality in the Health, Aging and Body Composition study cohort. <em>Journals of Gerontology Series A<\/em> 61(1):72-77. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16456196\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/16456196\/<\/a><\/li>\n\n<\/ol>\n\n<\/div>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Start your analysis Published research on joint ageing \u00b7 Read this before you buy another jar &#8220;Wear and tear.&#8221; That is the word you have been hearing for twenty years. In 2016 researchers put a different explanation on paper: the cells that maintain your joints have started doing other work. That changes your first step. [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_yoast_wpseo_title":"Not Worn Out: The Cells That Maintain Your Joints Have Started Doing Other Work","_yoast_wpseo_metadesc":"No new supplement. No waiting half a year to notice something. A free five-minute check that shows which signals in your own answers speak loudest.","_yoast_wpseo_meta-robots-noindex":"2","_yoast_wpseo_opengraph-image":"","_yoast_wpseo_opengraph-image-id":"","_yoast_wpseo_twitter-image":"","_yoast_wpseo_twitter-image-id":"","inline_featured_image":false,"footnotes":""},"class_list":["post-7108","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Not Worn Out: The Cells That Maintain Your Joints Have Started Doing Other Work<\/title>\n<meta name=\"description\" content=\"No new supplement. No waiting half a year to notice something. 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