{"id":14461,"date":"2026-11-02T16:00:00","date_gmt":"2026-11-02T16:00:00","guid":{"rendered":"https:\/\/bioprofile.com\/?page_id=14461"},"modified":"2026-11-06T03:36:14","modified_gmt":"2026-11-06T03:36:14","slug":"homa-beta","status":"publish","type":"page","link":"https:\/\/bioprofile.com\/es\/biomarkers\/homa-beta\/","title":{"rendered":"HOMA-beta"},"content":{"rendered":"\n<div id=\"content\" tabindex=\"-1\"><\/div>\n<style>@import url('https:\/\/fonts.googleapis.com\/css2?family=Poppins:ital,wght@0,400;0,600;0,700;0,800;1,400&display=swap');\n\/* ===========================================================================\n   BioProfile advertorial, the design Jesse approved on 2026-07-30, expressed\n   as a WordPress design system.\n\n   THE @import IS LOAD BEARING and must stay the first thing in this sheet (a\n   CSS @import after any rule is dropped by the parser). elementor_canvas does\n   not enqueue the theme's fonts, so without it the whole page falls back to the\n   system font. Caught by LOOKING at the live page on 2026-07-30, right after\n   the template was switched to canvas.\n\n   Everything is scoped to `.bp-adv`, so nothing here can reach the rest of\n   bioprofile.com, and core blocks are styled BY ELEMENT so a heading, a\n   paragraph, a quote, a list, an image or a button inserted by hand inside the\n   advertorial comes out on-design with no class to remember.\n\n   Jesse's design feedback, 2026-07-29 23:38, point by point:\n   1. the light green and the dark green are the preferred colours; grey may be\n      used but the page must NOT open grey;\n   2. more colour and variation across sections, e.g. a colour block on the left\n      or the right side of a section, without overdesign;\n   3. ONE H1, plain text on white; everything else H2 or H3; an H2 may carry its\n      own background colour so the page can be read from the headings alone; an\n      H3 keeps its section background and gets a bigger font size;\n   4. reuse the results page design feel;\n   5. Written by \/ Verified by, the placeholder blocks and noindex stay.\n\n   COLOUR PROVENANCE. Not one hex is invented.\n   - #b7cb32  LIGHT GREEN, brand manual \"colours rejuvenation protocol\"\n              (R183 G203 B51). Same value as --bp-lime in\n              brands\/bioprofile\/brand\/tokens.md.\n   - #006b62  DARK GREEN, brand manual, nourish the cells (R0 G107 B98).\n   - #005859  brand manual primary teal, the value the brand is built on.\n   - #228a62  brand manual, challenge the body (R34 G138 B98).\n   - #7ca64c  brand manual, calm the mind (R124 G166 B76).\n   - #dbd4cd  brand manual \"additional color\", the warm neutral.\n   - #B7CB3329 is the brand token --bp-lime-soft (light green at 16 percent).\n   - the gradients are the brand token layer's own, copied verbatim.\n\n   SPECIFICITY NOTE. Elementor's global kit emits `.elementor-kit-6 h2` style\n   rules at (0,1,1). Element rules below are written `.bp-adv h2`, also (0,1,1),\n   and win on source order because this sheet is inline in the body while the\n   kit is a <link> in the head. Component rules that MUST NOT lose carry two\n   classes, e.g. `.bp-adv .wp-block-button__link`.\n\n   LAYOUT NOTE. Vertical rhythm uses `margin-block` and never the `margin`\n   shorthand, so the measure rule `.bp-adv-sec > * { margin-inline: auto }` can\n   centre a block without being outranked by its own element rule.\n   =========================================================================== *\/\n\n.bp-adv {\n  --bp-ink: #212527;\n  --bp-teal: #005859;\n  --bp-forest: #006B62;\n  --bp-emerald: #228A62;\n  --bp-olive: #7CA64C;\n  --bp-lime: #B7CB33;\n  --bp-lime-soft: #B7CB3329;\n  --bp-sand: #DBD4CB;\n  --bp-white: #FFFFFF;\n  --bp-foot: #6b6b6b;\n  --bp-grad-dark: linear-gradient(237deg, rgba(0,88,89,0.00) 62.94%, #005859 100%), linear-gradient(90deg, rgba(34,138,98,0.00) 40%, #228A62 100%), #006B62;\n  --bp-grad-lime: linear-gradient(110deg, rgba(183,203,51,0.00) 36.06%, rgba(183,203,51,0.25) 97.65%), #FFFFFF;\n  --bp-font: 'Poppins','Segoe UI',Arial,sans-serif;\n  --bp-fs-h1: 44px; --bp-fs-h2: 31px; --bp-fs-h3: 24px; --bp-fs-pre: 15px;\n  --bp-fs-body: 17px; --bp-fs-small: 14px; --bp-fs-foot: 13px; --bp-fs-btn: 17px;\n  --bp-lh-body: 1.75;\n  --bp-s-1: 4px; --bp-s-2: 8px; --bp-s-3: 12px; --bp-s-4: 16px;\n  --bp-s-5: 24px; --bp-s-6: 32px; --bp-s-7: 44px; --bp-s-8: 72px;\n  --bp-measure: 760px; --bp-side: 40px;\n  --bp-radius-photo: 16px; --bp-radius-btn: 10px; --bp-radius-card: 20px;\n  --bp-shadow: 0 10px 30px rgba(0,88,89,0.10);\n  font-family: var(--bp-font);\n  font-size: var(--bp-fs-body);\n  line-height: var(--bp-lh-body);\n  color: var(--bp-ink);\n  background: var(--bp-white);\n  -webkit-font-smoothing: antialiased;\n}\n.bp-adv, .bp-adv * { box-sizing: border-box; }\n.bp-adv p, .bp-adv li, .bp-adv h1, .bp-adv h2, .bp-adv h3, .bp-adv blockquote,\n.bp-adv a, .bp-adv cite, .bp-adv span { overflow-wrap: break-word; min-width: 0; }\n\n\/* THE TOGGLE. One word in the block's own \"Additional CSS class(es)\" field\n   hides an optional component on the front end without deleting anything. *\/\n.bp-adv .bp-off { display: none !important; }\n\n\/* the page opens on green, never on grey (his point 1) *\/\n.bp-adv .bp-adv-rule {\n  height: 6px; border: 0; margin-block: 0; max-width: none;\n  background: linear-gradient(90deg, #005859 0%, #006B62 38%, #228A62 66%, #B7CB33 100%);\n}\n\n\/* --- section surfaces ------------------------------------------------------ *\/\n.bp-adv-sec { position: relative; background: var(--bp-white);\n  padding: var(--bp-s-8) var(--bp-side); margin-block: 0; }\n\/* the measure: every direct child of a section is the 760px text column *\/\n.bp-adv-sec > * { max-width: var(--bp-measure); margin-inline: auto; }\n.bp-adv-sec > *:last-child { margin-block-end: 0; }\n.bp-adv-sec--wash  { background: linear-gradient(180deg, #B7CB331F 0%, #B7CB3312 100%), #FFFFFF; }\n.bp-adv-sec--dark  { background: var(--bp-grad-dark); color: var(--bp-white); }\n.bp-adv-sec--dark p, .bp-adv-sec--dark cite, .bp-adv-sec--dark li { color: var(--bp-white); }\n.bp-adv-sec--offer { background: var(--bp-grad-lime); text-align: center; }\n.bp-adv-sec--hero  { padding-block-start: var(--bp-s-6); }\n.bp-adv-sec--disclosure { padding-block: var(--bp-s-6);\n  border-top: 1px solid var(--bp-sand); }\n\n\/* --- the side accent bar, his own example (\"a colour block on the left or the\n       right side of a section\"), design rev 3: a slim vertical bar hugging the\n       text column rather than a wide margin panel. Below 1100px the margin is\n       gone, so it becomes a slim top edge. ---------------------------------- *\/\n.bp-adv-rail { overflow: hidden; }\n.bp-adv-rail::before {\n  content: \"\"; position: absolute; top: var(--bp-s-7); bottom: var(--bp-s-7);\n  width: 6px; border-radius: 3px;\n  background: linear-gradient(180deg, var(--bp-forest) 0%, var(--bp-lime) 100%);\n}\n.bp-adv-rail--left::before  { left: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n.bp-adv-rail--right::before { right: calc((100% - var(--bp-measure)) \/ 2 - 34px); }\n@media (max-width: 1099px) {\n  .bp-adv-rail::before { left: 0; right: 0; width: auto; bottom: auto; top: 0;\n    height: 4px; border-radius: 0; background: var(--bp-lime); }\n}\n\n\/* --- CORE BLOCKS, styled by element. This is the part that makes an inserted\n       block come out on-design with no class. --------------------------------- *\/\n.bp-adv p { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv h1 { font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); }\n\/* an H2 is its own colour band, so the page can be read from the headings\n   alone (his point 3). Dark green on light sections, light green on the dark\n   one, so a heading always wins against its own background. *\/\n.bp-adv h2 {\n  font-size: var(--bp-fs-h2); font-weight: 700; line-height: 1.28;\n  margin-block: 0 var(--bp-s-5);\n  background: var(--bp-grad-dark); color: var(--bp-white);\n  padding: var(--bp-s-4) var(--bp-s-5);\n  border-radius: var(--bp-radius-btn);\n  border-left: 6px solid var(--bp-lime);\n}\n.bp-adv-sec--dark h2 { background: var(--bp-lime); color: var(--bp-ink);\n  border-left-color: var(--bp-forest); }\n\/* H3: same background as its section, bigger font (his point 3, verbatim) *\/\n.bp-adv h3 { font-size: var(--bp-fs-h3); font-weight: 700; line-height: 1.35;\n  color: var(--bp-forest); background: transparent; margin-block: 0 var(--bp-s-3); }\n.bp-adv-sec--dark h3 { color: var(--bp-lime); }\n.bp-adv ul, .bp-adv ol { font-size: var(--bp-fs-body); line-height: var(--bp-lh-body);\n  margin-block: 0 var(--bp-s-5); padding-left: var(--bp-s-5); }\n.bp-adv li { margin-block-end: var(--bp-s-2); }\n.bp-adv a { color: var(--bp-teal); text-decoration: underline; }\n.bp-adv a:hover { color: var(--bp-olive); }\n.bp-adv-sec--dark a, .bp-adv-sec--dark strong { color: var(--bp-lime); }\n.bp-adv strong { font-weight: 700; }\n\/* the highlight pill. Colours ride on the inline style core writes, so only\n   the shape lives here and any <mark> in the article picks it up. *\/\n.bp-adv mark {\n  padding: 0 10px; border-radius: 10px; display: inline;\n  -webkit-box-decoration-break: clone; box-decoration-break: clone;\n}\n\/* figures match the approved page exactly: card radius plus the soft shadow,\n   and a left-aligned caption rather than core's centred one *\/\n.bp-adv .wp-block-image { margin-block: var(--bp-s-5); margin-inline: auto; }\n.bp-adv .wp-block-image img { display: block; width: 100%; height: auto;\n  border-radius: var(--bp-radius-card); box-shadow: var(--bp-shadow); }\n.bp-adv .wp-block-image figcaption { font-size: var(--bp-fs-foot); line-height: 1.55;\n  color: var(--bp-foot); text-align: left; margin-block: var(--bp-s-2) 0; }\n.bp-adv .wp-block-embed, .bp-adv .wp-block-video { margin-block: var(--bp-s-5); }\n.bp-adv .wp-block-embed iframe, .bp-adv .wp-block-video video {\n  width: 100%; border-radius: var(--bp-radius-photo); }\n.bp-adv .wp-block-separator:not(.bp-adv-rule) { border: 0; border-top: 1px solid var(--bp-sand);\n  margin-block: var(--bp-s-5); }\n\n\/* quotes: core pullquote and core quote both land on the lime rule. The\n   font-size reset undoes core's own 1.5em on the figure, which would otherwise\n   leak into anything inside the quote that has no size of its own. *\/\n\/* margin-inline is load bearing, and it must be `auto` rather than `0`.\n   `blockquote` and `figure` carry a 40px side margin in the browser's own\n   default stylesheet, which indents the quote inside its rule and makes the\n   copy wrap early on a phone. But these blocks are direct children of a\n   section, so zeroing the side margin also defeats the measure rule\n   `.bp-adv-sec > * { margin-inline: auto }` and pins them to the left edge. *\/\n.bp-adv .wp-block-pullquote, .bp-adv .wp-block-quote {\n  border: 0; border-left: 5px solid var(--bp-lime); background: transparent;\n  padding: var(--bp-s-2) 0 var(--bp-s-2) var(--bp-s-5);\n  margin-block: var(--bp-s-5); margin-inline: auto;\n  text-align: left; font-size: var(--bp-fs-body);\n}\n.bp-adv .wp-block-pullquote blockquote { border: 0; margin: 0; padding: 0; }\n.bp-adv .wp-block-pullquote p, .bp-adv .wp-block-quote p {\n  font-size: 24px; line-height: 1.45; font-weight: 600;\n  margin-block: 0 var(--bp-s-2); color: var(--bp-forest); }\n.bp-adv .wp-block-pullquote cite, .bp-adv .wp-block-quote cite {\n  display: block; margin: 0; font-size: var(--bp-fs-small); color: var(--bp-foot);\n  font-style: normal; text-transform: none; }\n\n\/* buttons: two classes so core's own .wp-block-button__link cannot win *\/\n.bp-adv .wp-block-buttons { display: flex; justify-content: center;\n  margin-block: 0 var(--bp-s-4); }\n.bp-adv .wp-block-button__link {\n  display: inline-flex; align-items: center; justify-content: center; min-height: 48px;\n  background: var(--bp-teal); color: var(--bp-white); font-size: var(--bp-fs-btn);\n  font-weight: 700; line-height: 1.2; border-radius: var(--bp-radius-btn);\n  padding: 15px 44px; text-decoration: none; transition: background 250ms ease;\n  box-shadow: var(--bp-shadow);\n}\n.bp-adv .wp-block-button__link:hover { background: var(--bp-olive); color: var(--bp-white); }\n\n\/* --- slot 1: pre-headline, headline, sub-headline (Jesse's headline skill) --- *\/\n.bp-adv .bp-adv-preheadline {\n  color: var(--bp-forest); font-size: var(--bp-fs-pre); font-weight: 600; line-height: 1.5;\n  border-left: 4px solid var(--bp-lime); padding-left: var(--bp-s-3);\n  margin-block: 0 var(--bp-s-4);\n}\n.bp-adv .bp-adv-subheadline { font-size: 21px; line-height: 1.5; font-weight: 600;\n  color: var(--bp-forest); margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-standfirst { font-size: 19px; line-height: 1.65;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-lede { font-size: 18px; line-height: 1.7;\n  margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-byline { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  line-height: 1.6; margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-socialproof { font-size: var(--bp-fs-small); color: var(--bp-foot);\n  margin-block: 0 var(--bp-s-5); }\n\/* the offer headline above the CTA. Jesse asked for a second H1 here; the brand\n   doc's accessibility rule is one h1 per page, so it is rendered at H1 size and\n   stays an h2 element. Named in the close as the one design conflict. *\/\n.bp-adv h2.bp-adv-offerhead {\n  font-size: var(--bp-fs-h1); font-weight: 700; line-height: 1.22;\n  margin-block: 0 var(--bp-s-4); text-align: center; color: var(--bp-ink);\n  background: none; padding: 0; border: 0; border-radius: 0;\n}\n\n\/* --- Written by + Verified by. The avatar is the first child and spans the\n       three text rows, so the whole box is four ordinary paragraphs and stays\n       editable without nested columns. ---------------------------------------- *\/\n.bp-adv .bp-adv-authors {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-top: 4px solid var(--bp-lime); border-radius: var(--bp-radius-card);\n  box-shadow: var(--bp-shadow); padding: var(--bp-s-5);\n  margin-block: 0 var(--bp-s-4);\n  \/* auto-fit, so switching the verified box off leaves one full-width author\n     rather than a half-empty card *\/\n  display: grid; grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));\n  gap: var(--bp-s-5); align-items: start;\n}\n.bp-adv .bp-adv-author {\n  display: grid; grid-template-columns: 62px 1fr; gap: 0 var(--bp-s-3);\n  align-items: start; min-width: 0;\n}\n.bp-adv .bp-adv-avatar {\n  grid-row: 1 \/ span 3; width: 62px; height: 62px; border-radius: 50%;\n  background: #B7CB331F; border: 2px dashed var(--bp-olive);\n  display: flex; align-items: center; justify-content: center;\n  font-size: 10px; font-weight: 700; letter-spacing: 0.06em; color: var(--bp-forest);\n  margin-block: 0;\n}\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-avatar {\n  border-color: var(--bp-sand); background: #fff; color: var(--bp-foot); }\n.bp-adv .bp-adv-author-role {\n  font-size: 11px; font-weight: 700; letter-spacing: 0.08em; text-transform: uppercase;\n  color: var(--bp-forest); line-height: 1.6; margin-block: 0; }\n.bp-adv .bp-adv-author.is-placeholder .bp-adv-author-role { color: var(--bp-foot); }\n.bp-adv .bp-adv-author-name { font-size: 17px; font-weight: 700; line-height: 1.35;\n  margin-block: 0; }\n.bp-adv .bp-adv-author-cred { font-size: var(--bp-fs-foot); color: var(--bp-foot);\n  line-height: 1.55; margin-block: 0; }\n\/* the optional wrapper must not break the two-column grid of the box *\/\n.bp-adv .bp-adv-authors > .bp-optional { display: contents; }\n.bp-adv .bp-adv-authors > .bp-optional.bp-off { display: none !important; }\n\n\/* --- placeholders: image slot, video slot ---------------------------------- *\/\n.bp-adv .bp-slot {\n  display: flex; align-items: center; justify-content: center; text-align: center;\n  min-height: 180px; padding: var(--bp-s-4); margin-block: var(--bp-s-5) 0;\n  border: 2px dashed var(--bp-olive); border-radius: var(--bp-radius-photo);\n  background: #B7CB331F; color: var(--bp-forest);\n}\n.bp-adv .bp-slot p { font-size: var(--bp-fs-small); font-weight: 700; margin-block: 0; }\n.bp-adv .bp-slot--video { min-height: 260px; }\n\n\/* --- mid-article CTA band --------------------------------------------------- *\/\n.bp-adv .bp-adv-midcta {\n  background: var(--bp-grad-lime); border: 1px solid var(--bp-lime);\n  border-radius: var(--bp-radius-card); padding: var(--bp-s-5) var(--bp-s-4);\n  margin-block: var(--bp-s-6); text-align: center;\n}\n.bp-adv .bp-adv-midcta .wp-block-buttons { margin-block-end: var(--bp-s-2); }\n.bp-adv .bp-adv-midcta .bp-adv-foot { margin-block: 0; }\n\n\/* the closing CTA is one named unit in List View, so it moves and toggles as a\n   whole. It carries no box of its own: the spacing must read exactly as it does\n   on the approved page, where the three parts are plain siblings. *\/\n.bp-adv .bp-adv-ctablock { margin-block: 0 var(--bp-s-5); }\n.bp-adv .bp-adv-ctablock .wp-block-buttons { margin-block-end: var(--bp-s-4); }\n.bp-adv .bp-adv-ctablock .bp-adv-foot { margin-block: 0; }\n\n\/* --- the condition, slot 8: the results page reference-card shape ----------- *\/\n.bp-adv .bp-adv-condition {\n  background: var(--bp-white); border: 1px solid var(--bp-sand);\n  border-left: 5px solid var(--bp-lime); border-radius: var(--bp-radius-btn);\n  padding: var(--bp-s-4) var(--bp-s-5); font-weight: 600; box-shadow: var(--bp-shadow);\n}\n\n\/* --- the numbers card: the results page focus panel, same gradient, same\n       radius, same lime figures (\"use more of that design\") ------------------ *\/\n.bp-adv .bp-adv-numcard {\n  background: linear-gradient(135deg, var(--bp-teal) 0%, var(--bp-forest) 100%);\n  border-radius: var(--bp-radius-card);\n  padding: var(--bp-s-6) var(--bp-s-5) var(--bp-s-5);\n  box-shadow: var(--bp-shadow); margin-block: var(--bp-s-5) 0;\n  position: relative; overflow: hidden;\n}\n.bp-adv .bp-adv-numcard::after {\n  content: \"\"; position: absolute; right: -70px; top: -70px; width: 240px; height: 240px;\n  border-radius: 50%; background: rgba(255,255,255,0.05); pointer-events: none;\n}\n.bp-adv .bp-adv-numcard .wp-block-columns {\n  position: relative; z-index: 1; gap: var(--bp-s-5); margin-block: 0; }\n.bp-adv .bp-adv-numcard .wp-block-column { min-width: 0; }\n.bp-adv .bp-adv-num-v { font-size: 44px; font-weight: 700; line-height: 1.12;\n  color: var(--bp-lime); text-align: center; margin-block: 0 var(--bp-s-2); }\n.bp-adv .bp-adv-num-l { font-size: var(--bp-fs-small); line-height: 1.5;\n  color: rgba(255,255,255,0.92); text-align: center; margin-block: 0; }\n.bp-adv .bp-adv-numsrc { margin-block: var(--bp-s-5) 0; }\n\n\/* --- the proof slot: a dashed card until a consented quote exists. 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Lees waar een lage of hoge waarde op kan wijzen.\",\"inLanguage\":\"nl-NL\",\"dateModified\":\"2026-10-31\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/homa-beta\/\"},\"isPartOf\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/homa-beta\/\"},\"publisher\":{\"@id\":\"https:\/\/bioprofile.com\/#organization\"},\"about\":{\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/homa-beta\/#biomarker\"},\"citation\":[{\"@type\":\"CreativeWork\",\"name\":\"Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9.\",\"url\":\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3899825\/\"},{\"@type\":\"CreativeWork\",\"name\":\"MedlinePlus, U.S. National Library of Medicine. Insulin in Blood. Geraadpleegd op 31 oktober 2026.\",\"url\":\"https:\/\/medlineplus.gov\/lab-tests\/insulin-in-blood\/\"},{\"@type\":\"CreativeWork\",\"name\":\"BioProfile, de pakketten van het bloedonderzoek en de waarden in elk pakket.\",\"url\":\"https:\/\/bioprofile.com\/bloedonderzoek\/\"}]},{\"@type\":\"MedicalTest\",\"@id\":\"https:\/\/bioprofile.com\/biomarkers\/homa-beta\/#biomarker\",\"name\":\"HOMA-beta\",\"alternateName\":[\"HOMA-Beta\"]}]}<\/script>\n\n\n\n<section class=\"wp-block-group bp-adv bp-biomarker bp-biomarker--page is-layout-flow wp-block-group-is-layout-flow\">\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity bp-adv-rule\"\/>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--hero is-layout-flow wp-block-group-is-layout-flow\">\n\n<p class=\"bp-bm-crumbs wp-block-paragraph\"><a href=\"https:\/\/bioprofile.com\/es\/\">Inicio<\/a> \u203a <a href=\"https:\/\/bioprofile.com\/es\/biomarkers\/\">Biomarcadores<\/a> \u203a <span>HOMA-beta<\/span><\/p>\n\n\n\n<h1 class=\"wp-block-heading bp-adv-h1\">HOMA-beta: lo bien que tus c\u00e9lulas beta producen insulina<\/h1>\n\n\n\n<p class=\"bp-adv-standfirst wp-block-paragraph\">HOMA-beta es una estimaci\u00f3n calculada de lo bien que las c\u00e9lulas de tu p\u00e1ncreas producen insulina, a partir de tu glucosa e insulina en ayunas. Un valor bajo puede indicar un d\u00e9ficit en ese funcionamiento. Un valor alto puede indicar un p\u00e1ncreas que produce insulina extra porque tu cuerpo responde peor a la insulina.<sup>[1, 2]<\/sup><\/p>\n\n\n\n<p class=\"bp-adv-lede wp-block-paragraph\">En esta p\u00e1gina descubrir\u00e1s qu\u00e9 es el HOMA-beta, qu\u00e9 dicen las gu\u00edas sobre un valor demasiado bajo o demasiado alto, qu\u00e9 influye en tu valor y qu\u00e9 otros valores conviene mirar junto a \u00e9l.<\/p>\n\n\n\n<p class=\"bp-bm-names wp-block-paragraph\">Tambi\u00e9n llamado: HOMA-B, funci\u00f3n de las c\u00e9lulas beta seg\u00fan HOMA. En el laboratorio: no aplica.<\/p>\n\n\n\n<p class=\"bp-adv-byline wp-block-paragraph\">Actualizado el 31 de octubre de 2026<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<div class=\"wp-block-group bp-bm-toc is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-inhoud\">En esta p\u00e1gina<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li><a href=\"#bp-in-het-kort\">En resumen<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-is-homa-beta\">\u00bfQu\u00e9 es HOMA-beta?<\/a><\/li>\n\n\n<li><a href=\"#bp-waarom-het-ertoe-doet\">Por qu\u00e9 importa HOMA-beta<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-je-waarde-zegt\">Qu\u00e9 dice tu valor de HOMA-beta<\/a><\/li>\n\n\n<li><a href=\"#bp-wat-het-beinvloedt\">Qu\u00e9 influye en tu HOMA-beta<\/a><\/li>\n\n\n<li><a href=\"#bp-welke-pakketten\">Qu\u00e9 paquetes de BioProfile miden HOMA-beta<\/a><\/li>\n\n\n<li><a href=\"#bp-waarden-die-erbij-horen\">Valores relacionados<\/a><\/li>\n\n\n<li><a href=\"#bp-hoe-gemaakt\">C\u00f3mo se ha hecho esta p\u00e1gina<\/a><\/li>\n\n\n<li><a href=\"#bp-bronnen\">Fuentes<\/a><\/li>\n\n<\/ul>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-in-het-kort\">En resumen<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n\n<li>HOMA-beta estima el funcionamiento de tus c\u00e9lulas beta a partir de tu glucosa e insulina en ayunas.<sup>[1]<\/sup><\/li>\n\n\n<li>La insulina es una hormona de tu p\u00e1ncreas que ayuda a que la glucosa pase de tu sangre a tus c\u00e9lulas.<sup>[2]<\/sup><\/li>\n\n\n<li>Un valor bajo puede indicar un d\u00e9ficit en el funcionamiento de tus c\u00e9lulas beta.<sup>[1]<\/sup><\/li>\n\n\n<li>La estimaci\u00f3n tiene una precisi\u00f3n baja, y un m\u00e9dico revisa el resultado junto con otros resultados.<sup>[1, 2]<\/sup><\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-is-homa-beta\">\u00bfQu\u00e9 es el HOMA-beta?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">HOMA son las siglas de homeostasis model assessment. Es un modelo inform\u00e1tico que predice qu\u00e9 valores de glucosa e insulina en ayunas corresponden a un determinado funcionamiento de las c\u00e9lulas beta y a lo bien que el cuerpo responde a la insulina. Tus propios valores en ayunas se comparan con esas predicciones.<sup>[1]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">La insulina es una hormona que produce tu p\u00e1ncreas. Despu\u00e9s de comer, tu az\u00facar en sangre sube, y esa es la se\u00f1al para que tu p\u00e1ncreas libere m\u00e1s insulina. La insulina ayuda a que la glucosa pase de tu sangre a tus c\u00e9lulas, donde aporta energ\u00eda. Cuando tu az\u00facar en sangre baja, tu p\u00e1ncreas libera menos insulina.<sup>[2]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HOMA-beta es la parte del modelo que estima el funcionamiento de las c\u00e9lulas beta. En el estudio original, esa estimaci\u00f3n se relacionaba con una medici\u00f3n mediante una prueba de clamp (Rs = 0,61) y con una prueba de tolerancia a la glucosa por v\u00eda intravenosa (Rs = 0,64).<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarom-het-ertoe-doet\">Por qu\u00e9 importa el HOMA-beta<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Si tu p\u00e1ncreas produce muy poca insulina, o si tu cuerpo responde peor a la insulina, la glucosa no puede entrar bien en tus c\u00e9lulas. Entonces la glucosa se acumula en tu sangre y tu az\u00facar en sangre sube demasiado.<sup>[2]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Si tu cuerpo responde peor a la insulina, tu p\u00e1ncreas puede empezar a producir m\u00e1s insulina. As\u00ed tu glucosa en sangre se mantiene durante un tiempo dentro de un buen rango. Con el tiempo, puede que tu p\u00e1ncreas ya no consiga producir suficiente insulina, y tu glucosa en sangre puede subir demasiado.<sup>[2]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As\u00ed, HOMA-beta ayuda a ver qu\u00e9 parte de un az\u00facar en sangre elevado en ayunas tiene que ver con el funcionamiento de tus c\u00e9lulas beta, y qu\u00e9 parte con c\u00f3mo responde tu cuerpo a la insulina.<sup>[1]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-je-waarde-zegt\">Qu\u00e9 dice tu valor de HOMA-beta<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">El modelo HOMA de Matthews y colaboradores<\/h3>\n\n\n\n<figure class=\"wp-block-table bp-bm-table\"><table><thead><tr><th>Resultado<\/th><th>Qu\u00e9 puede indicar<\/th><th>Para qui\u00e9n<\/th><\/tr><\/thead><tbody><tr><td>Funci\u00f3n estimada de las c\u00e9lulas beta baja<sup>[1]<\/sup><\/td><td>Un d\u00e9ficit en el funcionamiento de las c\u00e9lulas beta, como causa que contribuye a un az\u00facar en sangre elevado en ayunas<\/td><td>Personas a quienes se les ha medido la glucosa y la insulina en ayunas<\/td><\/tr><tr><td>Cualquier resultado<sup>[1]<\/sup><\/td><td>Una estimaci\u00f3n de baja precisi\u00f3n: el coeficiente de variaci\u00f3n para el d\u00e9ficit de c\u00e9lulas beta es del 32%<\/td><td>Cualquier persona a quien se le calcula HOMA-beta<\/td><\/tr><tr><td>Sin valor l\u00edmite fijo<sup>[1]<\/sup><\/td><td>El modelo compara tus valores en ayunas con sus propias predicciones<\/td><td>Cualquier persona a quien se le calcula HOMA-beta<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"bp-bm-caption wp-block-paragraph\">Fuente: Matthews y colaboradores, el art\u00edculo original sobre el modelo HOMA en personas. El art\u00edculo no indica valores l\u00edmite para HOMA-beta.<sup>[1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HOMA-beta demasiado alto<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Un HOMA-beta alto puede indicar un p\u00e1ncreas que produce mucha insulina en relaci\u00f3n con tu glucosa en ayunas. Seg\u00fan MedlinePlus, tu p\u00e1ncreas puede producir m\u00e1s insulina si tu cuerpo responde peor a la insulina. Demasiada insulina en la sangre puede hacer que tu az\u00facar en sangre baje demasiado.<sup>[1, 2]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">HOMA-beta demasiado bajo<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Un HOMA-beta bajo puede indicar un d\u00e9ficit en el funcionamiento de tus c\u00e9lulas beta. En el modelo HOMA, es una de las dos causas que contribuyen a un az\u00facar en sangre elevado en ayunas. La otra es lo bien que tu cuerpo responde a la insulina. Si tu p\u00e1ncreas produce muy poca insulina, tu az\u00facar en sangre puede subir demasiado.<sup>[1, 2]<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BioProfile est\u00e1 trabajando en sus propias zonas para cada valor, de riesgo a \u00f3ptimo. Un m\u00e9dico valora esas zonas antes de que aparezcan en tu resultado.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-wat-het-beinvloedt\">Qu\u00e9 influye en tu HOMA-beta<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Comida y ayuno<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Despu\u00e9s de comer, tu az\u00facar en sangre y tu insulina suben juntos. HOMA-beta parte de valores en ayunas. Para un an\u00e1lisis de insulina, normalmente tienes que estar en ayunas de 8 a 12 horas: sin comer ni beber.<sup>[2, 1]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">La biotina como suplemento<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Si tomas biotina, o un suplemento que la contenga, seg\u00fan MedlinePlus debes dejar de tomarla al menos un d\u00eda antes de tu an\u00e1lisis.<sup>[2]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Medicamentos con insulina<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Algunas personas que usan insulina producen anticuerpos contra la insulina. Esos anticuerpos pueden alterar el an\u00e1lisis de insulina y dar un resultado incorrecto. Dile a tu m\u00e9dico si usas insulina, pero nunca dejes un medicamento sin consultarlo antes con tu m\u00e9dico.<sup>[2]<\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">C\u00f3mo responde tu cuerpo a la insulina<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Si tu cuerpo responde peor a la insulina, tu p\u00e1ncreas puede producir m\u00e1s insulina para que la glucosa entre en tus c\u00e9lulas. Seg\u00fan MedlinePlus, esa probabilidad es mayor si tienes una enfermedad del coraz\u00f3n, una enfermedad de los ovarios con muchos quistes, o la piel oscura, gruesa y aterciopelada en el cuello o las axilas.<sup>[2]<\/sup><\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-welke-pakketten\">Qu\u00e9 paquetes de BioProfile miden el HOMA-beta<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">HOMA-beta est\u00e1 incluido en BioProfile 121 y 150.<sup>[3]<\/sup><\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-3e41869c wp-block-buttons-is-layout-flex\">\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/bioprofile.com\/es\/analisis-de-sangre\/\">Ver los paquetes<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-waarden-die-erbij-horen\">Valores que la acompa\u00f1an<\/h2>\n\n\n\n<ul class=\"wp-block-list bp-bm-related\">\n\n<li><a href=\"https:\/\/bioprofile.com\/es\/biomarkers\/hba1c\/\">HbA1c<\/a>: muestra la cantidad media de glucosa en tu sangre a lo largo de unos meses, junto a la imagen puntual en ayunas que da HOMA-beta.<sup>[2]<\/sup><\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/es\/biomarkers\/trigliceridos\/\">Triglic\u00e9ridos<\/a>: las grasas de tu sangre, una segunda mirada a tu metabolismo junto a HOMA-beta.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/es\/biomarkers\/acido-urico\/\">\u00c1cido \u00farico<\/a>: un producto de desecho en tu sangre que se pone junto a tus valores de az\u00facar para tener una imagen m\u00e1s amplia de tu metabolismo.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/es\/biomarkers\/cetonas-en-orina\/\">Cetonas (orina)<\/a>: un valor del metabolismo en tu orina que se pone junto a tu az\u00facar en sangre y tu insulina.<\/li>\n\n\n<li><a href=\"https:\/\/bioprofile.com\/es\/biomarkers\/glucosa-orina\/\">Glucosa (orina)<\/a>: el az\u00facar en tu orina, una segunda mirada a c\u00f3mo gestiona tu cuerpo el az\u00facar junto a los valores de tu sangre.<\/li>\n\n<\/ul>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--wash is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-hoe-gemaakt\">C\u00f3mo se ha hecho esta p\u00e1gina<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">La redacci\u00f3n de BioProfile escribi\u00f3 esta p\u00e1gina el 31 de octubre de 2026 a partir de las fuentes que aparecen abajo, que le\u00edmos el 31 de octubre de 2026. Cada cifra de esta p\u00e1gina aparece en una de esas fuentes, con el n\u00famero de la fuente al lado. Una persona experta todav\u00eda tiene que revisar esta p\u00e1gina; tras esa revisi\u00f3n, el nombre de esa persona experta y la fecha de la revisi\u00f3n aparecer\u00e1n arriba. Esta p\u00e1gina explica y no da un diagn\u00f3stico. Si tienes un valor alterado, com\u00e9ntalo con tu m\u00e9dico de cabecera.<\/p>\n\n<\/div>\n\n\n\n<div class=\"wp-block-group bp-adv-sec bp-adv-sec--disclosure is-layout-flow wp-block-group-is-layout-flow\">\n\n<h2 class=\"wp-block-heading\" id=\"bp-bronnen\">Fuentes<\/h2>\n\n\n\n<ol class=\"wp-block-list bp-adv-srclist bp-bm-src\">\n\n<li>Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/3899825\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/3899825\/<\/a><\/li>\n\n\n<li>MedlinePlus, U.S. National Library of Medicine. Insulin in Blood. Consultado el 31 de octubre de 2026. <a href=\"https:\/\/medlineplus.gov\/lab-tests\/insulin-in-blood\/\" target=\"_blank\" rel=\"noopener\">https:\/\/medlineplus.gov\/lab-tests\/insulin-in-blood\/<\/a><\/li>\n\n\n<li>BioProfile, los paquetes del an\u00e1lisis de sangre y los valores de cada paquete. <a href=\"https:\/\/bioprofile.com\/es\/analisis-de-sangre\/\" target=\"_blank\" rel=\"noopener\">https:\/\/bioprofile.com\/es\/analisis-de-sangre\/<\/a><\/li>\n\n<\/ol>\n\n<\/div>\n\n<\/section>\n\n","protected":false},"excerpt":{"rendered":"<p>Inicio \u203a Biomarcadores \u203a HOMA-beta HOMA-beta: lo bien que tus c\u00e9lulas beta producen insulina HOMA-beta es una estimaci\u00f3n calculada de lo bien que las c\u00e9lulas de tu p\u00e1ncreas producen insulina, a partir de tu glucosa e insulina en ayunas. Un valor bajo puede indicar un d\u00e9ficit en ese funcionamiento. Un valor alto puede indicar un [&hellip;]<\/p>\n","protected":false},"author":18,"featured_media":0,"parent":6604,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_yoast_wpseo_title":"HOMA-beta: el funcionamiento de tus c\u00e9lulas beta | BioProfile","_yoast_wpseo_metadesc":"HOMA-beta estima lo bien que tus c\u00e9lulas beta producen insulina, a partir de tu glucosa e insulina en ayunas. Descubre qu\u00e9 puede indicar un valor bajo o alto.","_yoast_wpseo_meta-robots-noindex":"2","_yoast_wpseo_opengraph-image":"","_yoast_wpseo_opengraph-image-id":"","_yoast_wpseo_twitter-image":"","_yoast_wpseo_twitter-image-id":"","inline_featured_image":false,"footnotes":""},"class_list":["post-14461","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HOMA-beta: el funcionamiento de tus c\u00e9lulas beta | BioProfile<\/title>\n<meta name=\"description\" content=\"HOMA-beta estima lo bien que tus c\u00e9lulas beta producen insulina, a partir de tu glucosa e insulina en ayunas. 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