Home › Biomarkers › Systemic immune-inflammation index
In people with a liver disease who had undergone surgery, researchers set the cut-off at 330. In that group, a value of 330 or higher was linked to a less favourable course.[1]
On this page you can read what the systemic immune-inflammation index is, what the guidelines say about a value that is too low or too high, what affects your value and which values are best to look at alongside it.
Also known as: SII, immune-inflammation index. At the lab: not applicable.
The systemic immune-inflammation index is a calculated value that brings three types of blood cells together in one number. These are lymphocytes, neutrophils and platelets. These cells are counted in your blood. The index is calculated from those counts.[1]
Researchers developed this index in people with a liver disease who had undergone liver surgery. In them, a high index was linked to a less favourable course. So in that group, a high value may point to a greater chance that the disease returns.[1]
This research looked at a specific group of patients. There, the index was mainly studied as a tool to estimate how the condition would develop.[1]
In the research, the index predicted survival and the time without the disease returning. This held true even when the researchers took other characteristics into account.[1]
A value of 330 or higher was linked to growth of the disease into the blood vessels, to larger abnormalities in the liver and to an early return of the disease.[1]
The researchers see the index as a promising tool for care decisions in this group. The research looked at people with a liver disease, not at everyone.[1]
| Value | Can point to | Who it is for |
|---|---|---|
| 330 or higher[1] | a less favourable course and an early return of the disease | people with a liver disease after an operation on the liver |
| lower than 330[1] | a more favourable course than in the group with a high value | people with a liver disease after an operation on the liver |
| 330 or higher, with cells of the disease in the blood[1] | the disease returning more often and shorter survival | people in that group in whom such cells were found in the blood |
Source: Hu and colleagues, 2014. Studied in people with a liver disease after liver surgery. This cut-off applies to that group.[1]
In people with a liver disease after surgery, a value of 330 or higher may point to a less favourable course. It may also point to a greater chance that the disease returns early. This research gives no cut-off for other groups.[1]
BioProfile is working on its own zones for each value, from risk to optimal. A doctor reviews those zones before they appear in your result.
The index comes from the counts of neutrophils, lymphocytes and platelets. If one of those counts changes, the index changes with it.[1]
In the research, a high index was more common in people whose disease had grown into the blood vessels. The same was true for larger abnormalities in the liver.[1]
In the group with a value of 330 or higher, the researchers found more cells of the disease circulating in the blood. According to them, this may be linked to the less favourable course seen with a high index.[1]
The systemic immune-inflammation index is included in all five packages, from BioProfile 31 to BioProfile 150.[2]
The BioProfile editorial team wrote this page on 23 October 2026 from the sources below, which we read on 23 October 2026. Every number on this page appears in one of those sources, with that source's number beside it. An expert has yet to review this page; after that review, the expert's name and the date of the review will appear at the top. This page offers explanation, not a diagnosis. Discuss a value outside the normal range with your GP.
